There is an increasing interest in the development of surface-enhanced Raman scattering (SERS) sensors for rapid and accurate on-site detection hidden explosives. However, portable SERS methods trace explosive real systems remain scarce, mainly due to their relatively poor reliability portability. Herein, we present first demonstration a silicon-based analytical platform signal-on trinitrotoluene (TNT) explosives, which made silver nanoparticle (AgNP)-decorated silicon wafer chip (0.5 cm ×...

A facile strategy is reported here for synthesis of Zn-Cu-In-S/ZnS (ZCIS/ZnS) core/shell QDs to address the synthetic issues that unexpected blue-shift CuInS 2 -based nanocrystals.In this strategy, Zn 2+ ions are intentionally employed alloyed ZCIS core before ZnS shell coating, which contributes reduced in photoluminescence (PL) emission.The experimental results demonstrate elaborate effective reduction during growth.Particularly, a hypothesis proposed and proved explanation...

There currently exists increasing concerns on the development of a kind high-performance SERS platform, which is suitable for sensing applications ranging from molecular to cellular (e.g., bacteria) level. Herein, we develop novel universal chip, made graphene (G)–silver nanoparticle (AgNP)–silicon (Si) sandwich nanohybrids (G@AgNPs@Si), in AgNPs are situ grown silicon wafer through hydrofluoric acid-etching-assisted chemical reduction, followed by coating with single-layer via...

We present a SERS chip made of silver nanoparticle-decorated silicon wafer modified with internal standard molecules that is capable simultaneously detecting Pb²⁺ and Hg²⁺ in quantitative practical manners.

Dual-modal imaging techniques have gained intense attention for their potential role in the dawning era of tumor early accurate diagnosis. Chelate-free robust dual-modal nanoprobes with high efficiency and low toxicity are essential importance targeted vivo imaging. It is still a crucial issue to endow Cd-free bright fluorescence as well relaxivity. Herein, facile synthetic strategy was developed prepare Gd-doped CuInS/ZnS bimodal quantum dots (GCIS/ZnS, BQDs) optimized properties. The...

Radiation therapy has shown encouraging treatment efficacy on many types of tumors.

Rapid, sensitive, and accurate detection of adenosine triphosphate (ATP), the primary energy molecule, is critical for elucidation its unique roles in cell signaling many cellular reactions. Up to date, a major challenge still remaining fabricating surface-enhanced Raman scattering (SERS) aptamer sensors (aptasensors) suitable reliable quantification ATP. Herein, we develop ratiometric silicon SERS aptasensor ATP detection, which made uniform silver nanoparticles (Ag NPs)-modified wafer...

Metastasis is one of the main reasons for cancer treatment failure. Unfortunately, most approaches inevitably destroy extracellular matrix (ECM) during tumor cell elimination, thereby augmenting metastasis risk. Herein,...

A simple, straightforward, and reproducible strategy for the construction of a near-infrared (NIR) fluorescence nanoprobe was developed by coating CuInS2/ZnS quantum dots (CIS/ZnS QDs) with novel amphiphilic bioconjugate. The bioconjugate tailor-designed structure bovine serum albumin (BSA) as hydrophilic segment poly(ε-caprolactone) (PCL) hydrophobic part fabricated chemical coupling polymer chain to BSA via maleimide-sulfhydryl reaction. By incorporating CIS/ZnS QDs into cores...

Objective:The prognosis for gastric cancer (GC), a prevalent tumor of the digestive system, is unfavorable.The involvement glutathione peroxidase 3 (GPX3) in tumorigenesis significant, yet its specific role GC remains insufficiently investigated.Thus, aim this study was to determine potential impact GPX3 on and elucidate underlying mechanism.Methods: The expression survival were analyzed using TCGA data.Additionally, mRNA protein levels also assessed datasets from GTEx, GEPIA, HPA.A total 38...

Synthesis of CuInS-based quantum dots (QDs) in the organic phase is currently one fastest growing points nanotechnology. Most reported QDs are hydrophobic and cannot be directly used for biomedical applications without transfer. We put forward a one-pot synthetic strategy aimed at fabricating hydrophilic Zn–Cu–In–S/ZnS (ZCIS/ZnS) to vivo imaging surface treatment. This based on use ligand (6-sulfanyl-1-hexanol, MPH) non-coordinating solvents such as low molecular weight polyethylene glycol...

The effects of ionizing radiation on the reproductive system have always been a matter great interest. Both artificial and naturally occurring can directly or indirectly affect via introduction DNA single-strand double-strand breaks, excitation water molecules, generation free radicals. In order to quantitatively investigate function, 60Co γ irradiation was applied model organism, Caenorhabditis elegans (C. elegans). egg-laying embryo-hatching activities were observed for parent (F0) first 2...

Tritium is a water-soluble hydrogen isotope that releases beta rays during decay. In nature, tritium primarily exists as tritiated water (HTO), and its main source nuclear power/processing plants. recent decades, with the development of power industry, it necessary to evaluate impact on organisms. this study, fertilized zebrafish embryos are treated different HTO concentrations (3.7 × 103 Bq/ml, 3.7 104 105 Bq/ml). After treatment HTO, developed without evident morphological changes....

To study the radiosensitization effect of curcumin, a natural product with anti-inflammatory and anti-cancer properties, in bladder cancer cells identify specific role FLNA gene that process.CCK-8 method was initially adopted to proper interventional concentration curcumin. T24 were subjected CCK-8, flow cytometry, colony formation assay cell biological behaviors under different interventions. γ-H2AX test performed level damage cells. RT-qPCR Western blot conducted measure mRNA protein...

Radon exposure is significantly associated with lung cancer. concentration currently reduced mainly by physical methods, but there a lack of protective drugs or biochemical reagents for radon damage. This study aimed to explore the effect polydatin (PD) on radon-exposed injury. The results showed that PD can reduce ROS level, raise SOD activity, weaken migration ability, increase E-cad, and decrease mesenchymal cell surface markers (FN1, Vimentin, N-cad, α-SMA, Snail) in epithelial cells. In...

The effect of magnesium sulfate on brain tissue SD rats irradiated by 6MeV electron was investigated.SD were divided into three groups: control group, irradiation (IR group) and treated with (IR+M group). After being anesthetized, the whole brains IR group IR+M exposed to 6 MeV radiation. i.p. injected 10% (400 mg/kg) one day before radiation days five after And 1st, 3rd, 7th 14th radiation, euthanatized take for detection calcium, redox status cell apoptosis, as well expression NF-κB...

Abstract The fouling and stability are two most critical limiting factors for practical applications of surface‐enhanced Raman scattering (SERS)‐based microfluidic electrophoresis device. Herein, we present a novel biomimetic nanoengineering strategy to achieve SERS substrate featuring antifouling ability, good stability, reliable quantitative capability. Typically, by employing tea polyphenol as the reducing agent, made silver core‐gold shell nanostructures in situ grown on silicon wafer...

The reproductive system is vulnerable to ionizing radiation, which a hot research topic at present. We tested the effect of polydatin on spermatocytes(GC-1 cells) after X-ray irradiation. damage model C.elegans was established by 60Coγ-ray, and protective caused radiation evaluated. quantified ROS levels GC-1 cells irradiation with evaluated anti-apoptosis proper concentration. Differential genes were screened out from transcriptome sequencing results comparable GEO datasets. It proved that...

Microdosimetry is a tool for the investigation of microscopic energy deposition ionizing radiation. This work used Caenorhabditis elegans as model to estimate microdosimetric level at 60 Co gamma Monte Carlo software PHITS was employed establish irradiated nematodes model. The dose entire body and gonad 100 Gy calculated. injury levels radiation were evaluated by detection biological indicators. result experiment suggested that whole estimated be 99.9 ± 57.8 Gy, ranging from 19.6 332.2 Gy....