A5018891586- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Metabolomics and Mass Spectrometry Studies
- Pituitary Gland Disorders and Treatments
- COVID-19 Clinical Research Studies
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Plant Toxicity and Pharmacological Properties
- Treatment of Major Depression
- RNA and protein synthesis mechanisms
- Reconstructive Facial Surgery Techniques
- Microbial Metabolism and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroendocrine Tumor Research Advances
- Acute Ischemic Stroke Management
- Systemic Lupus Erythematosus Research
- Sunflower and Safflower Cultivation
- Mitochondrial Function and Pathology
- Chromatography in Natural Products
- Brain Metastases and Treatment
- Infectious Encephalopathies and Encephalitis
Qingdao University
2023-2024
Tongde Hospital of Zhejiang Province
2018-2024
Taian City Central Hospital
2023-2024
Sun Yat-sen University
2021-2022
Sun Yat-sen University Cancer Center
2021-2022
State Key Laboratory of Oncology in South China
2021-2022
University of Colorado Denver
2021
University of Colorado Cancer Center
2021
Zhejiang Academy of Forestry
2021
State Key Laboratory of Microbial Technology
2020
Understanding the underlying properties-dependent interactions of nanostructures with biological systems is essential to nanotoxicological research. This study investigates relationship between particle size and toxicity, further reveals mechanism injury, using silica particles (SP) diameters 30, 70, 300 nm (SP30, SP70, SP300) as model materials. The biochemical compositions liver tissues serum mice treated SP30, SP300 were analyzed by integrated metabonomics analysis based on gas...
Azvudine and nirmatrelvir-ritonavir are more extensively used to treat COVID-19 in China due their earlier approval by the National Medical Products Administration. However, there has been a scarcity of research directly comparing clinical outcomes between azvudine till now. We aimed make head-to-head comparison efficacy safety or hospitalized patients with China. This retrospective cohort study was conducted using data collected from Tongde Hospital Zhejiang Province December 2022 January...
Three doses of (+)-usnic acid (100, 200, and 240 mg/kg per d) were administered orally to Wistar rats for 8 days, metabonomic characterization acid-induced liver injury based on gas chromatography–mass spectrometry metabolic profiles was evaluated. Serum biochemical analysis histopathological examinations simultaneously performed. The liver/body weight ratio significantly increased in acid-treated groups, whereas serum alanine aminotransferase total bilirubin elevated. In sections 200 dosage...
Lupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE) and has important clinical implications in guiding treatment. N-glycosylation immunoglobulin G (IgG) plays key role the development SLE by affecting balance anti-inflammatory proinflammatory responses. This study aimed to evaluate performance IgG for diagnosing LN sample female patients.This case-control recruited 188 women with SLE, including 94 patients age-matched without LN. The profiles plasma N-glycans...
Abstract This study aimed to construct and externally validate a user-friendly nomogram-based scoring model for predicting the risk of urinary tract infections (UTIs) in patients with acute ischemic stroke (AIS). A retrospective real-world cohort was conducted on 1748 consecutive hospitalized AIS. Out these patients, total 1132 participants were ultimately included final analysis, 817 used construction 315 utilized external validation. Multivariate regression analysis applied develop model....
Protection of the structural and functional integrity blood-brain barrier (BBB) is crucial for treating ischemic stroke (IS). Hydroxysafflor yellow A (HSYA) quercetin (Quer), two main active components in edible medicinal plant
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) within 4.5 hours is an effective and routine therapy for acute ischemic stroke (AIS). The purpose of the study was to identify predictors functional outcome at 3 months hemorrhagic complications after IVT. A total 123 AIS patients treated intravenous alteplase were enrolled. Baseline clinical characteristics, medication disease history, radiographic laboratory data collected. measured by modified Rankin...
In this study, a high performance liquid chromatography coupled with multi-stage mass spectrometry method was developed for simultaneous characterization of alkaloids and flavonoids, the main active components, in Kushen diverse physical chemical properties. Forty-two major constituents, including sixteen twenty-six flavonoids were tentatively identified. Additionally, useful characteristic fragmentation pathways two types alkaloids, namely cytisine-type sparteine-type, positive ions mode...
Stroke is one of the leading causes death and disability globally, while intravenous thrombolysis with recombinant tissue plasminogen activator remains only Food Drug Administration (FDA)-approved therapy for ischemic stroke. The attempts to develop new treatments acute stroke meet costly spectacularly disappointing results, which requires both long time high costs, whereas repurposing safe existing drugs indications provides a cost-effective not time-consuming alternative. Vascular...
Objectives: To understand the medication being used among patients with chronic obstructive pulmonary diseases (COPD) in Chinese communities of large cities. Methods: A cross-sectional survey was carried out Beijing, Shanghai, Chengdu and Guangzhou total number as 678 COPD cases who were continuously recruited. Subjects face-to-face interviewed using a structured questionnaire medical records checked at same time. All data double entered into database under EpiData 3.1, analyzed by SAS 9.2....
Research has shown that FMS-like tyrosine kinase 3 (FLT3) may be a vital drug target for acute myeloid leukemia (AML). However, even though the clinically relevant F691L gatekeeper mutation conferred resistance to current FLT3 quizartinib, PLX3397 remained unaffected. In this study, protein-ligand interactions between domain (wild-type or F691L) with quizartinib were compared via an integrated computational approach. The classical molecular dynamics (MD) simulations in conjunction dynamic...
Butylphthalide (NBP), approved by the China National Medical Products Administration (NMPA) for treatment of ischemic stroke (IS), showed pleiotropic potentials against central nervous system (CNS) diseases, including neuroprotection and cognitive deficits improvement. However, effects corresponding modes action were not fully explored. This study was designed to investigate potential NBP IS-associated CNS diseases based on network pharmacology (NP) molecular docking (MD).IS inputted as...
Abstract Objective: Postoperative cerebrospinal fluid (CSF) leakage represents a challenge even for experienced pituitary surgeons. We aimed to quantitatively synthesize data from studies regarding the risk factors postoperative CSF after transsphenoidal surgery (TSS) adenoma (PA). Methods: PubMed, Web of Science, The Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang database, and VIP database were searched case–control cohort studies, focusing on associated...