A5100640700- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Pharmaceutical studies and practices
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Spondyloarthritis Studies and Treatments
- Neuroendocrine Tumor Research Advances
- Viral Infections and Immunology Research
- COVID-19 epidemiological studies
- Psoriasis: Treatment and Pathogenesis
- IgG4-Related and Inflammatory Diseases
- COVID-19 and healthcare impacts
- Ophthalmology and Eye Disorders
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- Cytokine Signaling Pathways and Interactions
- Vasculitis and related conditions
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipid metabolism and disorders
- Berberine and alkaloids research
- Telemedicine and Telehealth Implementation
Shandong Provincial Hospital
2016-2025
Shandong First Medical University
2016-2025
Shandong University
2014-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2020
Shandong University of Traditional Chinese Medicine
2020
Chongqing University
2018
Tianjin Central Hospital of Gynecology Obstetrics
2018
Wuhan No.1 Hospital
2017
Hebei North University
2016
Shandong Tumor Hospital
2016
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. Previous studies have suggested that interferon-lambda 1 (IFN-λ1), a type III interferon, plays immunomodulatory role. In this study we investigated its role in SLE, including correlation with activity, disorder and production of chemokines.We determined levels IFN-λ1 mRNA peripheral blood mononuclear cells (PBMC) serum protein patients SLE using real-time polymerase chain reaction (real-time PCR)...
IMPORTANCE Digital health applications have been shown to be effective in the management of chronic diseases with simple treatment targets. The potential clinical value digital rheumatoid arthritis (RA) has not well studied. OBJECTIVE To investigate whether assessing patient-reported outcomes using could result disease control for patients RA. DESIGN, SETTING, AND PARTICIPANTS This is a multicenter, open-label randomized trial 22 tertiary hospitals across China. Eligible participants were...
The aim of the study was to investigate expression NEK7-NLRP3 inflammasome signaling pathway in peripheral blood mononuclear cells (PBMCs) patients with systemic lupus erythematosus (SLE), as well its clinical significance.A total 38 SLE and 33 healthy volunteers were recruited. Real time PCR western blotting performed determine mRNA protein levels NEK7, NLRP3 components (NLRP3, ASC, Caspase-1), downstream cytokines (IL-1b IL-18) PBMCs from two groups. ELISA used detect serum IL-1b IL-18....
Background Developmental dysplasia of the hip (DDH) is one most common developmental disorders worldwide, caused by a combination genetic and environmental factors. Methods To investigate etiology DDH in proband (a 27-year-old male), we reviewed patient’s clinical data collected peripheral blood samples from his parents. Genomic DNA was extracted, polymerase chain reaction (PCR) amplification performed. Clinical whole-exome sequencing (WES) using next-generation (NGS) conducted to identify...
Abstract Objectives This study aimed to compare the efficacy and safety of subcutaneous methotrexate (SC MTX) oral MTX (OR in treating Chinese patients with active rheumatoid arthritis (RA). Methods included RA China. All were randomly assigned receive SC or OR MTX. The primary end point was Disease Activity Score-28 for erythrocyte sedimentation rate (DAS28-ESR) after 12 weeks treatment. Results DAS28-ESR scores groups significantly decreased compared baseline at week 12. least squares mean...
Interferon (IFN)-λ1 is a newly described cytokine that known for its proinflammatory activity in viral infection and cancer. Because recent studies indicated IFN-λ can influence significantly the innate adaptive immune response, we studied prototypic systemic autoimmune disease, rheumatoid arthritis (RA). It was found RA patients had higher mRNA levels PBMC serum of IFN-λ1 comparison with healthy matched controls ankylosing spondylitis (AS) patients. Although there no correlation between...
Objective To develop and conduct an initial validation of the Damage Index for IgG4-related disease (IgG4-RD DI). Methods A draft index items assessing organ damages in patients with IgG4-RD was generated by experts from Chinese Consortium (CIC). The preliminary DI refined using Delphi method, a final version consensus. 40 cases representing four types clinical scenarios were then selected, each two time points assessment at least 3 years follow-up. 48 rheumatologists 35 hospitals nationwide...
Abstract Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP , leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, neurogastrointestinal encephalomyopathy (MNGIE). However, the impact TP on lysosomes remains unclear, which are important for quality control and nucleic acid metabolism. Muscle biopsy tissue skin fibroblasts from MNGIE patients, patients m.3243 A > G encephalopathy, lactic acidosis stroke-like episodes (MELAS) healthy controls...
Summary Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of activating and inhibitory expressed on natural killer (NK) cells T cells, the genes which show extreme polymorphism. Some KIRs bind to human leucocyte antigen (HLA) class I subgroups, genetic interactions between KIR their ligand HLA have been shown be associated with several autoimmune diseases. The present study aimed investigate whether combinations HLA-Cw ligands associate susceptibility systemic lupus...
Killer cell immunoglobulin-like receptors (KIR) contribute to the pathogenesis of multiple auto-immune diseases via modulation NK-, NKT- and T-cells. Thus, we want know whether expression pattern KIR is associated with systemic lupus erythematosus (SLE) susceptibility.Here, real-time quantitative PCR fluorescence-activated sorting (FACS) were used measure stimulatory (sKIR) inhibitory (iKIR) mRAN protein levels on T-cells in both SLE patients healthy controls.In patients, CD158a/h...
Heart failure (HF) is characterized by cardiac dysfunction along with autonomic unbalance that associated increased renin‐angiotensin system (RAS) activity and elevated levels of proinflammatory cytokines (PICs). Renal denervation (RD) has been shown to improve function in HF, but the protective mechanisms remain unclear. The present study tested hypothesis RD ameliorates isoproterenol‐ (ISO‐) induced HF through regulation brain RAS PICs. Chronic ISO infusion resulted remarked decrease blood...
Objective The objective of this article is to investigate whether the aberrant expression collagen triple helix repeat containing-1 (CTHRC1) from patients with systemic lupus erythematosus (SLE) could contribute pathogenesis lupus. Methods We divided SLE into active groups (Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score ≥ 6) and inactive (SLEDAI < 6). Serum concentrations CTHRC1, interferon alpha, interleukin (IL)-28A IL-28B were determined using an enzyme-linked...
Previous publications indicated that genetic predisposition might play important roles in the onset of osteonecrosis femoral head (ONFH) systemic lupus erythematosus (SLE). Some gene loci such as complement C3d receptor 2 (CR2), nitric oxide synthase 3 (NOS3), collagen type II alpha 1 chain (COL2A1), protein tyrosine phosphatase non-receptor 22 (PTPN22), and transient potential cation channel subfamily V member 4 (TRPV4) were reported to be involved this process.To investigate whether risk...
This phase III trial (NCT04178850) evaluated the efficacy, safety, and immunogenicity of GB242, an infliximab biosimilar, vs. (Remicade®) reference product in patients with moderate-to-severe active rheumatoid arthritis (RA) combination methotrexate (MTX) therapy.Patients were randomized a 1:1 ratio to receive either GB242 or INF (3 mg/kg). Therapeutic equivalence clinical response according American College Rheumatology 20% (ACR20) rate at week 30 was declared if two-sided 95% CI for...
Single nucleotide polymorphisms (SNPs) can contribute to genetic predispositions or serve as markers that are associated with complex diseases. So far, a few SNP arrays containing limited number of SNPs have been used in routine testing. This study described an oligochip-based method genotypes two (-511 and -31) the promoter region interleukin (IL)-1 beta gene. The sensitivity this genotyping is derived from polymerase chain reaction (PCR)-amplified allele-specific primer-probes biotin label...
Objective. To determine the diagnostic value of anticitrullinated protein antibodies, second generation (ACPA2), by electrochemiluminescent immunoassay (ECLIA) and anti-Sa ELISA in a large cohort Chinese patients with early rheumatoid arthritis (RA). Methods. One hundred ninety-eight RA (< 1 yr duration), 112 other rheumatic diseases, 60 healthy individuals were studied. Results. The combination ACPA2 positivity had highest specificity (99.42%), but it rather low sensitivity (50.0%)....