A5032622149- Orthodontics and Dentofacial Orthopedics
- Supramolecular Self-Assembly in Materials
- Oral microbiology and periodontitis research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Temporomandibular Joint Disorders
- Polydiacetylene-based materials and applications
- dental development and anomalies
- Advanced Sensor and Energy Harvesting Materials
- Autophagy in Disease and Therapy
- Dental Radiography and Imaging
- Periodontal Regeneration and Treatments
- Advanced Glycation End Products research
- Advanced NMR Techniques and Applications
- Mesenchymal stem cell research
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Conducting polymers and applications
- Salivary Gland Disorders and Functions
- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Oral Health Pathology and Treatment
- Extracellular vesicles in disease
- Dental Trauma and Treatments
- Immune Response and Inflammation
Stomatological Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
Beike Biotechnology (China)
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Sichuan University
2014-2022
State Key Laboratory of Oral Diseases
2016-2022
West China Hospital of Sichuan University
2020-2022
China Medical University
2019-2021
Beijing Fengtai Disease Prevention and Control Center
2021
Stomatology Hospital
2020
Variation in the molecular architecture significantly affects electronic and supramolecular structure of biomolecular assemblies, leading to dramatically altered piezoelectric response. However, relationship between building block chemistry, crystal packing quantitative electromechanical response is still not fully understood. Herein, we systematically explored possibility amplify piezoelectricity amino acid-based assemblies by engineering. We show that a simple change side-chain acetylated...
The role and underlying mechanism of exosomes derived from human periodontal ligament stem cells (PDLSC) in osteogenesis are unclear. In the present study, we identified PDLSCs found that osteogenic induction can enhance ability PDLSC-derived promoting differentiation rat bone marrow (BMSCs). To investigate mechanism, analyzed exosomal miRNA expression profiles undifferentiated differentiated by RNA sequencing. results showed seventy-two miRNAs were upregulated thirty-five downregulated...
Supramolecular packing dictates the physical properties of bio-inspired molecular assemblies in solid state. Yet, modulating stacking modes supramolecular remains a challenge and structure-property relationship is still not fully understood, which hampers rational design structures to fabricate materials with desired properties. Herein, we present co-assembly strategy modulate N-terminally capped alanine-based (Ac-Ala) by changing amino acid chirality mixing nonchiral bipyridine derivative...
Abstract Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on pathophysiology essential for enhancing their therapeutic effects periodontitis treatment. As promising localized drug delivery systems and engineering scaffolds, hydrogels have gained significant interest controlled sustained release bioactive agents applications. rational can facilitate bacterial control modulate...
Abstract Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one major pathophysiological mechanisms responsible for progression diabetes complications such as non‐alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly toxic effects on periodontitis. Therefore, we reviewed current vivo, vitro, clinical detrimental periodontitis, focusing its molecular...
Abstract Structural diversity of biomolecules leads to various supramolecular organizations and asymmetric architectures self‐assemblies with significant piezoelectric response. However, the piezoelectricity biomolecular has not been fully explored relationship between structures remains poorly understood, which hinders development biomaterials. Herein, for first time, vitamin‐based power generation is systematically explored. X‐ray diffraction studies revealed that vitamin molecules can...
Abstract Objectives This study aimed to compare the efficacy and safety of subcutaneous methotrexate (SC MTX) oral MTX (OR in treating Chinese patients with active rheumatoid arthritis (RA). Methods included RA China. All were randomly assigned receive SC or OR MTX. The primary end point was Disease Activity Score-28 for erythrocyte sedimentation rate (DAS28-ESR) after 12 weeks treatment. Results DAS28-ESR scores groups significantly decreased compared baseline at week 12. least squares mean...
Purpose: Oxidative stress is a major pathogenesis of certain ocular surface diseases. This study investigated the association oxidative and cellular autophagy in corneal epithelium. Methods: We applied hydrogen peroxide (H2O2) to induce damage cultured human epithelial (HCE) cells rat corneas. Cell viability, Western blotting caspase 8, TUNEL staining were conducted measure injury. The production reactive oxygen species (ROS) was measured levels following marker key factors ROS also detect...
Abstract The role of ROS in stem cell biology has not been fully illustrated and understood. Here we compared the different responses investigated mechanism underlying oxidative stress induced by hydrogen peroxide (H 2 O ) between murine corneal epithelial progenitor line (TKE2) mature cells (MCE). TKE2 showed a homeostasis strong resistance to H . reduced production ROS, inhibited generation enzyme NADPH oxidase 4 (NOX4), increased dual specificity phosphatase 6 (DUSP6). Furthermore,...