A5000283319- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Supramolecular Chemistry and Complexes
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Chemical Synthesis and Analysis
- Photochromic and Fluorescence Chemistry
- RNA Interference and Gene Delivery
- Cholesterol and Lipid Metabolism
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Diamond and Carbon-based Materials Research
- Antimicrobial Peptides and Activities
- Electrospun Nanofibers in Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Anesthesia and Neurotoxicity Research
- Synthesis and Properties of Aromatic Compounds
- Carbon Nanotubes in Composites
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Metal-Organic Frameworks: Synthesis and Applications
Chongqing University
2021-2025
University of Alberta
2024-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
East China Normal University
2024
Nanjing Tech University
2024
Green Chemistry
2024
Shanghai Jiao Tong University
2008-2023
Shanghai Children's Medical Center
2019-2023
Fujian Women and Children Hospital
2023
Nanyang Technological University
2022
Control over the handedness of circularly polarized luminescence (CPL) in supramolecular gels is special significance biology and optoelectronics; however, it still remains a great challenge to precisely efficiently regulate chirality CPL. Herein, chiral phenylalanine-derived hydrogelator achiral coumarin derivatives can co-assemble into nanofibrous hydrogels with controllable chirality, CPL these be inverted by through noncovalent interactions, which further tuned at will incorporating...
The misfolding of proteins and peptides potentially leads to a conformation transition from an α-helix or random coil β-sheet-rich fibril structures, which are associated with various amyloid degenerative disorders. Inhibition the β-sheet aggregate formation control structural could therefore attenuate development amyloid-associated diseases. However, transitions extraordinarily complex processes that still not fully understood thus challenging manipulate. To simplify this complexity,...
Abstract Realization of a self-assembled, nontoxic and eco-friendly piezoelectric device with high-performance, sensitivity reliability is highly desirable to complement conventional inorganic polymer based materials. Hierarchically organized natural materials such as collagen have long been posited exhibit electromechanical properties that could potentially be amplified via molecular engineering produce technologically relevant piezoelectricity. Here, by using simple, minimalistic, building...
The Diffusion Probabilistic Model (DPM) has recently gained popularity in the field of computer vision, thanks to its image generation applications, such as Imagen, Latent Models, and Stable Diffusion, which have demonstrated impressive capabilities sparked much discussion within community. Recent investigations further unveiled utility DPM domain medical analysis, underscored by commendable performance exhibited segmentation model across various tasks. Although these models were originally...
Abstract To understand the behavior of chiral nanostructures, it is critical importance to study how achiral molecules regulate chirality such nanostructures and what main driving forces for regulation processes are. In this work, supramolecular helical nanofibers consisting phenylalanine‐based enantiomers inverted by bis(pyridinyl) derivatives through co‐assembly. This inversion mainly mediated intermolecular hydrogen bonding interactions between additives molecules, which may induce...
Most natural biomolecules may exist in either of two enantiomeric forms. Although nature, amino acid biopolymers are characterized by l-type homochirality, incorporation d-amino acids the design self-assembling peptide motifs has been shown to significantly alter enzyme stability, conformation, self-assembly behavior, cytotoxicity, and even therapeutic activity. However, while functional metabolite assemblies ubiquitous throughout nature play numerous important roles including physiological,...
Abstract Self‐assembled peptide hydrogels represent the realization of nanotechnology into biomedical products. There is a continuous quest to identify simplest building blocks and optimize their critical gelation concentration (CGC). Herein, minimalistic, de novo dipeptide, Fmoc‐Lys(Fmoc)‐Asp, as an hydrogelator with lowest CGC ever reported, almost fourfold lower compared that large hexadecapeptide previously described, reported. The dipeptide self‐assembles through unusual unprecedented...
Modulation of the structural diversity diphenylalanine-based assemblies by molecular modification and solvent alteration has been extensively explored for bio- nanotechnology. However, regulation transition based on this minimal building block into tunable supramolecular nanostructures further construction smart materials with multiple responsiveness are still an unmet need. Coassembly, tactic employed natural systems to expand architectural space, rarely explored. Herein, we present a...
Conformational transition of proteins and peptides into highly stable, β-sheet-rich structures is observed in many amyloid-associated neurodegenerative disorders, yet the precise mechanism amyloid formation at molecular level remains poorly understood due to complex structures. Short provide simplified models for studying basis assembly that governs β-sheet fibrillation processes underlying inhibition amyloid-like Herein, we report a supramolecular coassembly strategy transformation stable...
Molecular stacking modes, generally classified as H-, J-, and X-aggregation, play a key role in determining the optoelectronic properties of organic crystals. However, control transformation specific molecule is an unmet challenge,
Abstract Organic electrochemical transistors (OECTs) provide the opportunity to fabricate flexible biosensors with high sensitivity. However, there are currently very few methods improve selectivity of OECT sensors. In this work, nitrogen/oxygen‐codoped carbon cloths (NOCCs) prepared by carbonization polyaniline‐wrapped at 750 °C under different atmospheres. The resulting NOCC electrodes exhibit sensing behaviors toward ascorbic acid (AA) and dopamine (DA), enabling fabrication sensors...
Variation in the molecular architecture significantly affects electronic and supramolecular structure of biomolecular assemblies, leading to dramatically altered piezoelectric response. However, relationship between building block chemistry, crystal packing quantitative electromechanical response is still not fully understood. Herein, we systematically explored possibility amplify piezoelectricity amino acid-based assemblies by engineering. We show that a simple change side-chain acetylated...
Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the basic building units, have been shown to self-assemble form highly ordered structures through supramolecular interactions. The fabrication functional biomaterials comprised extremely simple biomolecules has gained increasing interest due advantages biocompatibility, easy functionalization, structural modularity. In particular, acid based assemblies attractive physical characteristics for various...
Abstract Biologically inspired peptide‐based materials, as novel charge transport have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical through supramolecular interactions. Therefore, materials hold great promise for applications emerging electronic fields such sensing, energy harvesting, storage,...
A new concept in which only the molecular target, such as a thiol-bearing protein, can activate phototrigger has been demonstrated. Such target-activatable phototriggers comprise three parts: 7-aminocoumarin phototrigger, an electron acceptor (maleimide) that efficiently quenches coumarin excited state, and caged leaving group attached to coumarin. In absence of mercaptans, photoinduced transfer between maleimide effectively blocks both fluorescence photocleavage pathways. Thiol-bearing...
A multiresponsive hydrogel system coassembled from phenylalanine derivative gelator (LPF2) and azobenzene (Azo) (PPI) is constructed, which can respond to temperature, pH, host-guest interaction, photoirradiation. set of techniques including circular dichroism, Fourier transform infrared spectroscopy, (1)H NMR, X-ray powder diffraction confirm that the formed through hydrogen bonds between amide moieties/pyridine carbonyl groups, enduing with properties make it possible control cell...
The formation of ordered nanostructures by metabolites is gaining increased interest due to the simplicity building blocks and their natural occurrence. Specifically, aromatic amino acids possess ability form supramolecular interactions limited solubility in aqueous solution. Unexpectedly, l-tyrosine (l-Tyr) almost 2 orders magnitude less soluble water compared l-phenylalanine (l-Phe). However, underlying mechanism not fully understood as l-Tyr more polar. Here, we explore utilization...