A5042956895- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Chronic Myeloid Leukemia Treatments
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Healthcare Systems and Reforms
- Healthcare Systems and Public Health
- Cancer therapeutics and mechanisms
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Rheumatoid Arthritis Research and Therapies
- Artificial Intelligence in Healthcare
- Hepatitis C virus research
- Sarcoma Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Acute Lymphoblastic Leukemia research
Eisai (United States)
2025
Peking University People's Hospital
2016-2024
Peking University
2016-2024
Fujian Medical University
2017-2019
Fuzhou General Hospital of Nanjing Military Command
2014-2015
Objective: To analyze the clinical outcome and prognostic factor in pediatric patients with core binding factor-acute myeloid leukemia (CBF-AML). Methods: A total of 121 newly diagnosed CBF-AML enrolled from Aug. 2005 to Sep. 2017 were retrospectively reviewed. Cumulative incidence relapse (CIR), event-free survival (EFS) overall (OS) rates estimated by Kaplan-Meier method factors evaluated Cox regression SPSS. Results: Of patients, 120 assessed for bone marrow remission after induction...
Aim . To assess the surgical outcomes of temporo‐parieto‐occipital (TPO) and parieto‐occipital (PO) disconnection surgery for children with intractable posterior quadrantic epilepsy a unilateral quadrant lesion based on MRI functional imaging abnormality in TPO region one side. Methods A retrospective review data 12 who underwent or PO disconnective was carried out from September 2009 to 2012. Three‐dimensional surface reconstructions scans intraoperative electrophysiological monitoring were...
OBJECT The objectives of this study were to describe a novel minimal-access subtemporal approach for selective resection the amygdala and hippocampus in patients with medically refractory mesial temporal lobe epilepsy (MTLE) due hippocampal sclerosis, analyze related outcomes. METHODS authors analyzed data from all cases involving unilateral MTLE sclerosis who treated amygdalohippocampectomy via posterior through relatively small craniotomy, without neuronavigation system, at their...
Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism not clear. heat-resistant peptide (SVHRP), isolated from of Buthus martensii Karsch, has an anti-epileptic effect by reducing seizure behavior according to modified Racine scale. The present study aimed investigate molecular SVHRP on temporal lobe epilepsy. hippocampus and hippocampal neurons kainic acid-induced epileptic rats were treated with at different doses duration. Quantitative RT-PCR...
Abstract Cerebral cavernous malformations (CMs) are vascular affecting any part of the central nervous system. Clinical data and surgical outcomes for 27 pediatric patients with CM-related epilepsy were retrospectively reviewed. The mean age onset was 12.71 ± 4.09 years, duration 2.34 1.95 years. All treated microsurgery resection CMs, hemosiderin rim, secondary epileptogenic zone if necessary. follow-up period 6.34 3.35 overall postoperative positive. Note that 77.8% seizure-free...
Magnetic resonance imaging (MRI)-negative epilepsy is associated with poor clinical outcomes prognosis. The present study was aimed to assess whether intracranial 3D interictal and ictal electroencephalography (EEG) findings, a combination of EEG at different depth, in addition clinical, scalp EEG, positron emission tomography–computed tomography (PETCT) data help predict outcome series patients MRI-negative frontal lobe (FLE) after surgery. Patients FLE who were presurgically evaluated by...
To explore the predictive effect of European treatment and outcome study long term survival (ELTS) score on outcomes in chronic myeloid leukemia phase (CML-CP) children.
Objective: To explore the clinical characteristics and prognosis of children with chronic myeloid leukemia in blast phase (CML-BP) . Methods: The characteristics, treatment measures, survival outcomes 28 CML-BP were analyzed our hospital from January 2008 to November 2022. Results: male female ratio was 1.15∶1. median age diagnosis 10 years, follow-up time 79 months. During CML, four BP, one accelerated (AP) 23 (CP). Among CML-CP, 75% had progressed directly CP BP without experiencing AP....
Objective: To analyze the clinical characteristics of children with Burkitt lymphoma (BL) and to summarize mid-term efficacy China Net Childhood Lymphoma-mature B-cell 2017 (CNCL-B-NHL-2017) regimen. Methods: Clinical features 436 BL patients who were ≤18 years old treated CNCL-B-NHL-2017 regimen from May April 2021 analyzed retrospectively. at disease onset therapeutic effects different stages risk groups compared. Survival analysis was performed by Kaplan-Meier method, Cox regression used...
<h3>Background</h3> Rheumatoid arthritis (RA) patients can cause joint swelling and tenderness, affect the patient9s mental health. Previous studies showed that 13–47% of RA suffered from anxiety and/or depression. Hospital depression scale (HADS) is usually used to evaluate patients9 health, which consists 14 items divided into an subscale (HADS-A) a (HADS-D). Disease activity score in 28 joints (DAS28) one most tool assess disease activity. Both HADS DAS28 assessments were commonly led by...
<h3>Background</h3> Combination therapy with DMARDs for treating RA is considered as standard of care. However, certain rates adverse events (AEs) are unavoidable. The stigma which drug should be stopped first once AEs emerge. decisions made by clinicians always empirically. <h3>Objectives</h3> To develop an algorithm decision making on withdraw sequence in face combination based data mining and machine learning from the SSDM. <h3>Methods</h3> SSDM interactive mobile disease management tool,...
Background: Behcet´s disease (BD) is a systemic autoimmune that affects multiple organ systems with recurrent oral ulcers, genital ulcers and skin lesions. Disease Current Activity Form (BDCAF) Electronic Medical Record-based Index (EMRAI) are commonly used internationally to evaluate the activity of BD. Objectives: This study aimed analyze clinical characteristics, level activity, incidence anxiety depression for Chinese BD patients. Patients can perform self-management SSDM. Methods: SSDM...
Background: WHO survey showed that the prevalence of anxiety and depression in Chinese population patients with chronic diseases were between 3.1% - 4.2% 7.3%, respectively. Ankylosing Spondylitis Disease Activity Score (ASDAS) Hospital Anxiety Depression Scale (HADS) are commonly used to evaluate AS patients’ disease activity mental health. All those assessments mainly performed by health professionals (HCPs) paper questionnaire previously. SSDM is a novel smart management tool allows do...