A5101623918- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Erythrocyte Function and Pathophysiology
- Dermatological and COVID-19 studies
- Autoimmune and Inflammatory Disorders Research
- Erythropoietin and Anemia Treatment
- Gout, Hyperuricemia, Uric Acid
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Brucella: diagnosis, epidemiology, treatment
- Pancreatitis Pathology and Treatment
- Telemedicine and Telehealth Implementation
- Case Reports on Hematomas
- Ocular Diseases and Behçet’s Syndrome
- Pancreatic function and diabetes
- Higher Education Learning Practices
- Pluripotent Stem Cells Research
- PARP inhibition in cancer therapy
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
Tongji Hospital
2010-2023
Huazhong University of Science and Technology
2010-2023
Chinese People's Liberation Army
2020
People's Liberation Army 401 Hospital
2020
AIDS Clinical Trials Group
2015
Huangshi Central Hospital
2007
The clinical features of rheumatic patients with coronavirus disease 2019 (COVID-19) have not been reported. This study aimed to describe the COVID-19 in and provide information for handling this situation practice.This is a retrospective case series study. Deidentified data, including gender, age, laboratory radiological results, symptoms, signs, medication history, were collected from 2326 diagnosed COVID-19, 21 cases combination disease, Tongji Hospital between 13 January 15 March...
During the 2019 Coronavirus disease (COVID-19) outbreak, malnutrition may contribute to COVID-19 adverse outcomes. We conducted a clinical epidemiological analysis investigate association of with hospitalized duration in patients COVID-19. Retrospective survey study. Taikang Tongji (Wuhan) hospital Wuhan, China. 139 In total, from Infection Department February 2020 April were analyzed retrospectively. used "Global leadership Initiative on Malnutrition(GLIM)" assessment standard published...
Abstract Anti-dsDNA antibodies are pathogenically heterogeneous, implying distinct origins and antigenic properties. Unexpectedly, during the clinical molecular characterization of autoantibodies to endonuclease DNase1L3 in patients with systemic lupus erythematosus (SLE), we identified a subset neutralizing anti-DNase1L3 previously catalogued as anti-dsDNA. Based on their variable heavy-chain (V H ) gene usage, these can be divided two groups. One group is encoded by inherently autoreactive...
Wnt-signaling pathway is implicated in pancreatic development and functional regulation of mature beta-cells. Wnt3a/Wnt activation expands islet cell mass vitro by increasing proliferation decreasing apoptosis beta-cells, thereby enhancing its function. However, the signaling pathways that mediate these effects remain unknown. By using a clonal beta-cell line (NIT-1), we examined role IRS2/PI3K mediation Wnt3a-stimulated growth. Real-time PCR Western blot were employed to investigate...
Gangliosides GM1 is a good marker of membrane microdomains (lipid rafts) with important function in cellular activation processes. In this study we found that expression on CD4+ T cells and memory (CD45RO/CD4) were dramatic increased after stimulation phytohaemagglutinin vitro. Next, examined the peripheral blood CD8+ from 44 patients SLE 28 healthy controls by flow cytometry. was further analyzed serum soluble CD30 (sCD30), IL-10, TNF-alpha clinical parameters. The mean fluorescence...
Background. Since the first diagnosed case of infection with novel coronavirus (SARS-CoV-2), there has been a rapid spread disease an increasing number cases confirmed every day, as well rising death toll. An association reported between acute kidney injury (AKI) and mortality in patients infected SARS-CoV-2. Therefore, our study was conducted to explore possible risk factors AKI whether factor for worse outcome, especially among (COVID-19). Methods. We included all hospital admissions or...
Tumor Necrosis Factor-alpha (TNF- α ) was reported to increase autophagy in rheumatoid arthritis human fibroblast-like synovial cell (RA-HFLS). We investigated different levels of TNF- exposed RA-HFLS by focusing on the relationship and apoptosis. normal (HFLS) were stimulated presence or absence 3-methyladenine (3-MA) chloroquine (CQ). Cell apoptosis detected flow cytometry. Autophagy determined through expression LC3, Beclin1, P62 measured Western Blot analysis as well Confocal Laser...
Erythropoietin (EPO) is a cytokine that regulates the proliferation, differentiation, and survival of erythroid progenitor cells. EPO has recently been demonstrated to have tissue-protective role by mediating anti-apoptotic signals through erythropoietin receptor (EPOR) in various tissues, including brain, liver, heart. We previously examined pancreatic β-cell line NIT-1 cells for expression EPOR real-time PCR determined these were protected against cytokine-induced apoptosis. The precise...
There are several therapeutic strategies available for the treatment of an acute gout attack and prevention recurrent flares, they include nonsteroid anti-inflammatory drugs. This prospective study was aimed at evaluating efficiency safety diacerein in combination with febuxostat on urate control, global assessments disease activity, self-monitored gouty flare times, inflammatory markers, clinical symptoms associated their life quantity patients refractory gout. A total 64 were sequentially...
Background and objectives: Hepatic stellate cell (HSC) activation is the cardinal factor due to accumulation of extracellular matrix proteins during development liver fibrosis. The aim present study was find new targets for developing drugs treat fibrosis, by screening key genes involved in hepatic cells. Methods: Differentially expressed were identified through TCGA database. RT-PCR, immunohistochemistry (IHC) assay, western blot, ELISA performed evaluate expression levels FAT10 fibrotic...
This study aims to compare the platelet distribution width (PDW) level in patients with systemic lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH) that erythematosus alone (SLE-non-PAH) and evaluate clinical value of PDW early diagnosis SLE-PAH.We analyzed 80 SLE-PAH (1 males, 79 females; 34.9±12.3 years; range, 19 77 years) 154 sex- age-matched SLE-non-PAH (4 150 mean age 36.7±12.4 69 hospitalized between June 2011 April 2018. All underwent transthoracic Doppler...
Objective To study the risk factors influencing efficacy of uric acid therapy (ULT) in gout patients and to establish an unconditional logistic regression model predict ULT. Methods Seventy-two cases were divided into non-health education group (Group A) health B) followed up for totally 24 weeks. The clinical data measured at baseline including blood lipid, glucose serum (SUA) C-reactive protein (CRP) level flow cytometry determination peripheral NK cell percentage joint ultrasound...
BackgroundAn outbreak of coronavirus disease 2019 (COVID-19) started in December, 2019. The epicentre, Wuhan Hubei Province, was lockdown. From Jan 23, 2020, most hospitals only focused on patients with COVID-19, and chronic diseases could not visit their physicians clinic had no access to prescriptions. Smart System Disease Management (SSDM) is a series mobile applications for management that includes both patient physician interfaces. After training clinic, regularly do activity...
Abstract DNase1L3 deficiency is an inborn error of immunity that causes monogenic systemic lupus erythematosus (SLE) in humans. Here, we identified one third patients with sporadic SLE have antibodies to DNase1L3. Like deficiency, found anti-DNase1L3 features associated immune pathways activated by immunogenic self-DNA, including elevated dsDNA and prominent expression the interferon myeloid/neutrophil signatures. Interestingly, 40-80% serum contain 9G4 idiotype, which encoded autoreactive...
Objective To investigate the clinical features and mechanism feasibility of plasma exchange (PE) in treating systemic lupus erythematosus (SLE) complicated with acute pancreatitis (AP). Methods A retrospective analysis SLE associated AP was done based on HIS Tongji Hospital. Totally 24 SLEAP patients were admitted to hospital from March 2006 May 2014. Patients' serum amylase, lipase interleukin (IL)-6 concentration measured before after exchange. According different therapy strategy,...
Clinical practice teaching in out-patient department is an important part of general internal clinical for medical students. From 2010, eight-year program students Huazhong University Science and Technology began their rotation the medicine. The one-on-one tutoring style was used teaching. We combined teacher demonstration method with supervision practice, carried out periodical case discussion. At end each stage, regular evaluation examination taken. It has been proved that our mode can not...