A5101965160- Prenatal Screening and Diagnostics
- Genetic Associations and Epidemiology
- Mosquito-borne diseases and control
- Genomic variations and chromosomal abnormalities
- Firm Innovation and Growth
- Cardiovascular Effects of Exercise
- Regional Economic and Spatial Analysis
- RNA modifications and cancer
- Nerve injury and regeneration
- Entrepreneurship Studies and Influences
- Electric Power System Optimization
- Systemic Lupus Erythematosus Research
- HVDC Systems and Fault Protection
- Adipose Tissue and Metabolism
- Tribology and Lubrication Engineering
- Adenosine and Purinergic Signaling
- Hemophilia Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Travel-related health issues
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Frequency Control in Power Systems
- Urinary and Genital Oncology Studies
- Immune Cell Function and Interaction
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Surface Polishing Techniques
Huazhong University of Science and Technology
2008-2024
University of South China
2021
Pennsylvania State University
2021
Hunan Children's Hospital
2021
Shanghai Sixth People's Hospital
2020
Shanghai Jiao Tong University
2020
Shanghai Stomatological Hospital
2020
BGI Group (China)
2013-2020
Shanghai Children's Hospital
2020
Wuhan Center for Disease Control and Prevention
2018-2019
Macrophages perform key functions in tissue homeostasis that are influenced by the local environment. Within tumor microenvironment, tumor-associated macrophages can be altered to acquire properties enhance growth. Here, we found lactate, a metabolite high concentration within anaerobic environment, activated mTORC1 subsequently suppressed TFEB-mediated expression of macrophage-specific vacuolar ATPase subunit ATP6V0d2. Atp6v0d2-/- mice were more susceptible growth, with enhanced...
The applications of massively parallel sequencing technology to fetal cell-free DNA (cff-DNA) have brought new insight non-invasive prenatal diagnosis. However, most previous research based on maternal plasma has been restricted aneuploidies. To detect specific parentally inherited mutations, invasive approaches obtain are the current standard in clinic because experimental complexity and resource consumption previously reported approaches.Here, we present a simple effective method for...
Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently MI through genome-wide association studies were
Gangliosides GM1 is a good marker of membrane microdomains (lipid rafts) with important function in cellular activation processes. In this study we found that expression on CD4+ T cells and memory (CD45RO/CD4) were dramatic increased after stimulation phytohaemagglutinin vitro. Next, examined the peripheral blood CD8+ from 44 patients SLE 28 healthy controls by flow cytometry. was further analyzed serum soluble CD30 (sCD30), IL-10, TNF-alpha clinical parameters. The mean fluorescence...
The embryonic genome, including genotypes and haplotypes, contains all the information for preimplantation genetic diagnosis, representing great potential mendelian disorder carriers to conceive healthy babies.We developed a strategy obtain full genome β-thalassemia-carrier couple have second baby. We carried out sequencing single blastomere cells family trio further analysis pipeline, recovery of missing alleles, removal majority errors, phasing genome.The final accuracy homozygous...
Idiopathic ventricular tachycardia (VT) occurs in structurally normal hearts and accounts for a significant number of all types VT. The genome-wide association study is the most effective strategy identifying novel genetic variants common diseases. However, no has been reported idiopathic VT.We conducted first VT Chinese Han population using discovery with 246 cases 648 controls replication 222 >4072 controls. Candidate genes were functionally characterized zebrafish. Real-time RT-PCR...
In this paper, a miniaturized bioreactor for accelerating nerve growth is developed to investigate potentially bi-directional peripheral neural interface based on tissue engineering. The consisting of two parallel chambers that are extended conduct controlled trials optimized neuronal culture. chamber used improve the micro-environment in vitro regeneration CO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> incubator, whereas process...
Peripheral nerve injury requires a physical bridge across the lesion, which is limited by insufficient supply of donor nerves. Here, we developed new miniaturized bioreactor system for axon stretch growth. Dorsal root ganglia explants were first placed on two adjoining substrates and formed synaptic connections. The bundles border between top bottom membranes then stretched in stepwise fashion microstepper motor system. After several days stretch, tracts could reach lengths that develop into...
It has continuously received universal attention from various local authority and academic circles about the issue that why how Industrial Cluster can attract talents. This article introduced magnetic field concept to promulgate rule of talent agglomeration in Cluster, where human resources quantity, quality structure be changed through Magnetic Effect which attracts talents symbiotic effect caused by gathering talents, thus further promotes Cluster's economical development; Meanwhile, Based...
Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds common variants that are associated with human height at genome-wide levels significance. However, only a small fraction phenotypic variation can be explained by the aggregate these variants. In large study African-American men and women (n = 14,419), we genotyped analyzed 966,578 autosomal SNPs across entire genome using linear mixed model variance components approach...
The problem of entrepreneurship in industrial clusters has increasingly become the focal question study regional economy. By investigating and studying cases entrepreneurs from five big our country, paper proposes incubation subjects, environments atmospheres enterprising talents clusters, builds evaluation cables clusters' venture performance, tests its reliability validity. Furthermore, multiple linear regression analysis method is applied to analyze influences factors on performance...
Quinine (QN) remains an effective drug for malaria treatment. However, quinine resistance (QNR) in Plasmodium falciparum has been reported many malaria-endemic regions particularly African countries. Genetic polymorphism of the P. Na+/H+ exchanger (pfnhe1) is considered to influence QN susceptibility. Here, ms4760 alleles pfnhe1 were analysed from imported parasites isolated returning travellers Wuhan, Central China.A total 204 dried-blood spots collected during 2011-2016. The polymorphisms...
With the rapid development of electric power construction , transmission lines and surrounding geological environment influence each other that has become increasingly serious, however, there is not formed yet a set complete more scientific environmental evaluation system in at present. In this paper, on basis using experience industries research study put forward method specifically for lines. Evaluation established planning period also corresponding index. The conclusion can provides...
It has continuously received universal attention from various local authority and academic circles about the issue that why how Industry Cluster can attract talents. This article introduced magnetic field concept to promulgate rule of talent agglomeration in Cluster, where human resources quantity, quality structure be changed through Magnetic Effect which attracts talents symbiotic effect is caused by gathering talents, thus further promotes Cluster's economical development. Based on...
Abstract Purpose Genome sequencing (GS) is potentially the most suitable diagnostic tools for fetal CNS structural anomalies. However, its efficacy hasn’t been proved in large cohort of Methods Patients were enrolled by a multiple-level referral system when structure anomalies found ultrasonography. Samples from fetuses subjected to GS. Results Data 162 with 11 frequent types was collected. The overall diagnosis yield GS 38.9%. 36(20.3%) detected chromosomal and pathogenic CNVs. Pathogenic...