A5076784172- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Fetal and Pediatric Neurological Disorders
- Insect Resistance and Genetics
- Remote-Sensing Image Classification
- Insect-Plant Interactions and Control
- Medical Image Segmentation Techniques
- Cancer Genomics and Diagnostics
- Image Retrieval and Classification Techniques
- Parvovirus B19 Infection Studies
- Corporate Finance and Governance
- Rough Sets and Fuzzy Logic
- Video Surveillance and Tracking Methods
- Insect Pest Control Strategies
- Firm Innovation and Growth
- Banking stability, regulation, efficiency
- Islamic Finance and Banking Studies
- Working Capital and Financial Performance
- Corruption and Economic Development
- Remote Sensing and Land Use
- Labor Movements and Unions
- Image and Signal Denoising Methods
- Media Influence and Politics
- Infrared Target Detection Methodologies
- Congenital Anomalies and Fetal Surgery
Wuhan University
2021-2024
Development Research Center
2024
Shaanxi University of Science and Technology
2024
Huazhong Agricultural University
2022-2023
Shandong University of Science and Technology
2023
Sichuan University
2023
Geely (China)
2023
Chifeng University
2017
BGI Group (China)
2012-2016
University of Chinese Academy of Sciences
2016
ABSTRACT Objective To report the feasibility of fetal chromosomal deletion/duplication detection using a novel bioinformatic method low coverage whole genome sequencing maternal plasma. Method A practical F etal C opy‐number nalysis through Maternal P lasma S equencing (FCAPS), integrated with GC‐bias correction, binary segmentation algorithm and dynamic threshold strategy, was developed to detect deletions/duplications >10 Mb by (about 0.08‐fold). The sensitivity/specificity resultant...
Tze Kin Laua*, Fang Chenb*, Xiaoyu Pan, Ritsuko K. Poohd, Fuman Jiangb, Yihan Lib, Hui Xuchao Shengpei Chenb & Xiuqing Zhang*ba Department of Obstetrics and Gynaecology, The Chinese University Hong Kong, Kongb Guangdong Province Key Laboratory Genome, BGI-Shenzhen, Shenzhen, Chinac School Bioscience Bioengineering, South China Technology, Guangzhou, Chinad CRIFM Clinical Research Institute Fetal Medicine PMC, Osaka, Japan
This study demonstrates noninvasive prenatal testing (NIPT) for Duchenne muscular dystrophy (DMD) using a newly developed haplotype-based approach.Eight families at risk DMD were recruited this study. Parental haplotypes constructed target-region sequencing data from the parents and probands. Fetal hidden Markov model through maternal plasma DNA sequencing. The presence of linked to mutant alleles in males indicated affected fetuses. method was further validated by comparing inferred...
ABSTRACT Objective The objective of this study is to assess the performance noninvasive prenatal testing for trisomies 21 and 18 on basis massively parallel sequencing cell‐free DNA from maternal plasma in twin pregnancies. Method A double‐blind was performed over 12 months. total 189 pregnant women carrying twins were recruited seven hospitals. Maternal detect 18. fetal karyotype used as gold standard estimate sensitivity specificity sequencing‐based test. Results There nine cases trisomy...
Copy number variations (CNVs), a common genomic mutation associated with various diseases, are important in research and clinical applications. Whole genome amplification (WGA) massively parallel sequencing have been applied to single cell CNVs analysis, which provides new insight for the fields of biology medicine. However, WGA-induced bias significantly limits sensitivity specificity detection. Addressing these limitations, we developed practical bioinformatic methodology detection at...
Abstract Aphis gossypii Glover is one of the most serious pests in China, and management this pest mainly relies on insecticides. However, resistance status A. Central China still unknown. Therefore, study, we firstly determined susceptibility 15 field populations from to six chemical insecticides using leaf‐dipping method during 2020 2021 explored potential mechanisms these populations. Most have evolved low high levels imidacloprid (RR = 5.98–2352.96‐fold), thiamethoxam 5.98–2194.96‐fold),...
Evaluating the sublethal effects of insecticide is crucial for protecting and utilizing natural enemies. In this study, we determined acetamiprid afidopyropen on Harmonia axyridis (Pallas) explored potential molecular mechanisms underlying these through transcriptomics analysis. The results showed that concentrations significantly reduced adult fecundity longevity F0 H. decreased survival time rate F1 generation. Sublethal prolonged developmental 4th instar larvae in Additionally, treatments...
The applications of massively parallel sequencing technology to fetal cell-free DNA (cff-DNA) have brought new insight non-invasive prenatal diagnosis. However, most previous research based on maternal plasma has been restricted aneuploidies. To detect specific parentally inherited mutations, invasive approaches obtain are the current standard in clinic because experimental complexity and resource consumption previously reported approaches.Here, we present a simple effective method for...
This paper investigates the problems of stability analysis and stabilization for stochastic time-delay systems. Firstly, this uses martingale theory to investigate expectations cross terms containing Itô integral. On basis this, an improved delay-dependent criterion is derived delay In derivation process, mathematical development avoids bounding terms, neither model transformation method nor free-weighting-matrix used. Thus, leads a simple shows less conservatism. Secondly, on result,...
Background Copy number variations (CNVs) represent an important type of genetic variation that deeply impact phenotypic polymorphisms and human diseases. The advent high-throughput sequencing technologies provides opportunity to revolutionize the discovery CNVs explore their relationship with However, most existing methods depend on depth show instability low sequence coverage. In this study, using coverage whole-genome (LCS) we have developed effective population-scale CNV calling (PSCC)...
Abstract Conductive hydrogels (CHs) are attracted more attention in the flexible wearable sensors field, however, how to stably apply CHs underwater is still a big challenge. In order achieve usage of aquatic environments, integrated properties such as water retention ability, resistance swelling, toughness, adhesiveness, linear GF sensing, and long‐term necessary consider, but rarely reported previous reports. This paper proposes prepared using cationic aromatic monomers along with...
Fetal chromosomal abnormalities are the most common reasons for invasive prenatal testing. Currently, G-band karyotyping and several molecular genetic methods have been established diagnosis of abnormalities. Although these testing highly reliable, major limitation remains restricted resolutions or can only achieve limited coverage on human genome at one time. The massively parallel sequencing (MPS) technologies which reach single base pair resolution allows detection genome-wide intragenic...
Ultra-low coverage sequencing (ULCS) is one of the most promising strategies for based clinical application. These applications, especially prenatal diagnosis, have a strict requirement turn-around-time; therefore, application ULCS restricted by current high throughput platforms. Recently, emergence rapid platforms, such as MiSeq and Ion Proton, brings strategy into new era. The comparison their performance could shed lights on potential in large-scale clinic trials. In this study, we...
Short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs) have been already used to perform noninvasive prenatal paternity testing from maternal plasma DNA. The frequently technologies were PCR followed by capillary electrophoresis SNP typing array, respectively. Here, we developed a (NIPAT) based on with DNA sequencing. We evaluated the influence factors (minor allele frequency (MAF), number of total SNP, fetal fraction effective sequencing depth) designed three different...
Abstract This article studies the relationship between service liberalization and productivity of high‐tech manufacturing. Examining sudden relaxation FDI regulation in several sectors China, this finds that improves firms' TFP. The effect is greater non‐SOEs, firms with a higher degree dependence, located regions better institutional environments. Furthermore, after liberalization, all sizes have more outsourcing expenditures spend less on intermediate inputs. Only large‐sized increase...
Background The discovery of cell free fetal DNA (cff-DNA) in maternal plasma has brought new insight for noninvasive prenatal diagnosis. Combining with the rapidly developed massively parallel sequencing technology, detection chromosome aneuploidy and single base variation been successfully validated. However, few studies discussed possibility pathogenic CNVs detection. Methodology/Principal Findings A novel algorithm was firstly tested 5 pairs parents heterozygote α-thalassemia Southeast...