A5101565274- Prenatal Screening and Diagnostics
- Genomic variations and chromosomal abnormalities
- Genomics and Phylogenetic Studies
- Fetal and Pediatric Neurological Disorders
- Genomics and Rare Diseases
- Saffron Plant Research Studies
- Energy, Environment, Economic Growth
- Advanced Nanomaterials in Catalysis
- Iron-based superconductors research
- Insect Resistance and Genetics
- Parvovirus B19 Infection Studies
- Aquaculture Nutrition and Growth
- Agriculture and Biological Studies
- Plant Stress Responses and Tolerance
- Cancer Genomics and Diagnostics
- Soil and Environmental Studies
- Photosynthetic Processes and Mechanisms
- Nanomaterials for catalytic reactions
- Genetic Mapping and Diversity in Plants and Animals
- Coleoptera Taxonomy and Distribution
- Genetic diversity and population structure
- Gold and Silver Nanoparticles Synthesis and Applications
- 2D Materials and Applications
- Medicinal Plants and Bioactive Compounds
- Social and Behavioral Studies
Guangdong Academy of Forestry
2024-2025
Fujian Agriculture and Forestry University
2020-2025
Anhui Polytechnic University
2024
Northwest Normal University
2023-2024
Central China Normal University
2023-2024
China Electronic Product Reliability and Environmental Test Institute
2024
Ministry of Agriculture and Rural Affairs
2023
South China Agricultural University
2023
Ji Hua Laboratory
2023
Ningbo Kangning Hospital
2023
ABSTRACT Objective To report the feasibility of fetal chromosomal deletion/duplication detection using a novel bioinformatic method low coverage whole genome sequencing maternal plasma. Method A practical F etal C opy‐number nalysis through Maternal P lasma S equencing (FCAPS), integrated with GC‐bias correction, binary segmentation algorithm and dynamic threshold strategy, was developed to detect deletions/duplications >10 Mb by (about 0.08‐fold). The sensitivity/specificity resultant...
This study demonstrates noninvasive prenatal testing (NIPT) for Duchenne muscular dystrophy (DMD) using a newly developed haplotype-based approach.Eight families at risk DMD were recruited this study. Parental haplotypes constructed target-region sequencing data from the parents and probands. Fetal hidden Markov model through maternal plasma DNA sequencing. The presence of linked to mutant alleles in males indicated affected fetuses. method was further validated by comparing inferred...
ABSTRACT Objective The objective of this study is to assess the performance noninvasive prenatal testing for trisomies 21 and 18 on basis massively parallel sequencing cell‐free DNA from maternal plasma in twin pregnancies. Method A double‐blind was performed over 12 months. total 189 pregnant women carrying twins were recruited seven hospitals. Maternal detect 18. fetal karyotype used as gold standard estimate sensitivity specificity sequencing‐based test. Results There nine cases trisomy...
Background Copy number variations (CNVs) represent an important type of genetic variation that deeply impact phenotypic polymorphisms and human diseases. The advent high-throughput sequencing technologies provides opportunity to revolutionize the discovery CNVs explore their relationship with However, most existing methods depend on depth show instability low sequence coverage. In this study, using coverage whole-genome (LCS) we have developed effective population-scale CNV calling (PSCC)...
The tuning of magnetic phase, chemical potential, and structure is crucial to observe diverse exotic topological quantum states in $MnBi_2Te_4(Bi_2Te_3)_m$ (m = 0, 1, 2, & 3). Here we show a ferromagnetic (FM) phase with chiral crystal $Mn(Bi_{1-x}Sb_x)_4Te_7$, obtained via the growth conditions Sb concentration. Unlike previously reported which exhibits FM transitions only at high doping levels, our samples ($T_C$ 13.5 K) 15%-27% levels. Furthermore, single x-ray diffraction refinements...
This paper addresses the effect of population urbanization on Fine Particulate (PM2.5) in Yangtze River Economic Belt China from 2006 to 2016 by employing PM2.5 remote sensing data and using Stochastic Impacts Regression Population, Affluence Technology (STIRPAT) model. The study contributes growing empirical literature addressing heterogeneity, spillover, dynamic effects spatial panel modeling process simultaneously. results show that has a significant impact with positive spillover being...
Ultra-low coverage sequencing (ULCS) is one of the most promising strategies for based clinical application. These applications, especially prenatal diagnosis, have a strict requirement turn-around-time; therefore, application ULCS restricted by current high throughput platforms. Recently, emergence rapid platforms, such as MiSeq and Ion Proton, brings strategy into new era. The comparison their performance could shed lights on potential in large-scale clinic trials. In this study, we...
Emerging studies have demonstrated that whole-genome sequencing (WGS) is an efficient tool for copy-number variants (CNV) detection, particularly in probe-poor regions, as compared to chromosomal microarray analysis (CMA). However, the cost of testing beyond economical routine usage and lengthy turn-around time not ideal clinical implementation. In addition, demand computational resources also reduces probability integration into each laboratory. Herein, a protocol providing CNV detection...
Albino seedlings that arise during seed reproduction can have a significant impact on plant growth and breeding. In this research, we present the first report of albino occurrences in process Prunus salicina describe cytological, physiological, transcriptomic changes observed seedlings. The which were several plum cultivars exhibited abnormal chloroplast ultrastructure perturbed stomatal structure. Compared to normal seedlings, photosynthetic pigment contents decreased by more than 90%,...
Background Currently very few noninvasive molecular genetic approaches are available to determine zygosity for twin pregnancies in clinical laboratories. This study aimed develop a novel method by using maternal plasma target region sequencing. Methods We constructed statistic model calculate the possibility of each type likelihood ratios (Li) and empirical dynamic thresholds targeting at 4,524 single nucleotide polymorphisms (SNPs) loci on 22 autosomes. Then two dizygotic (DZ)...
Abstract Recent advances in 2D magnetism have heightened interest layered magnetic materials due to their potential for spintronics. In particular, semiconducting antiferromagnets exhibit intriguing low‐dimensional behavior with both charge and spin as carrier controls. However, synthesis of these compounds is challenging remains rare. Here, first‐principles based high‐throughput search conducted screen potentially stable mixed metal phosphorous trichalcogenides (MM ′ P 2 X 6 , where M are...
Based on the dual-factor model of mental health (DFM) and cumulative risk (CR) model, this study aimed to investigate impact CR left-behind children's underlying mechanism involved, specifically mediating role coping style moderating gratitude in relationship between health. The random cluster sampling method was applied collect data CR, style, gratitude, life satisfaction, depression from 705 children (374 boys, Mage = 12.20 ± 1.25). moderated mediation analyses indicated that: (1)...
Advancement of the oil tea industry requires development high-yielding and superior-quality varieties Camellia oleifera, a major oilseed crop. However, traditional breeding methods, hampered by lengthy cycles low selection accuracy, significantly constrain process. Identifying single nucleotide polymorphisms (SNPs) associated with target traits, applying molecular marker-assisted (MAS) for these can thereby shorten amplify efficiency. In this study, we utilized hexaploid C. oleifera as...
ABSTRACT Objective To report a novel method of rapidly detecting fetal aneuploidies for spontaneous abortion using ultra‐low whole genome sequencing data on benchtop platform. Method Fetal chorionic villus samples were collected from 40 cases with 22 different types aneuploidy. Genomic DNA each sample was extracted and sequenced Illumina MiSeq Unique reads read lengths generated analyzed z‐score test. Results The entire test finished in 48 hours. An average 102 k unique obtained sample, all...
The onsite next generation sequencing (NGS) of Ebola virus (EBOV) genomes during the 2013-2016 epidemic in Western Africa provides an opportunity to trace origin, transmission, and evolution this virus. Herein, we have diagnosed a cohort EBOV patients Sierra Leone 2015, late phase outbreak. surviving had recovery process characterized by decreasing viremia, fever, biochemical parameters. sequenced through longitudinal blood samples these showed dynamic intra-host substitutions acute...
Abstract BACKGROUND Amniocentesis is a common procedure, the primary purpose of which to collect cells from fetus allow testing for abnormal chromosomes, altered chromosomal copy number, or small number genes that have single- multibase defects. Here we demonstrate feasibility generating an accurate whole-genome sequence either cellular cell-free DNA (cfDNA) amniotic sample. METHODS cfDNA and isolated cell pellet 31 amniocenteses were sequenced approximately 50× genome coverage by use...
Consumer behavior, by definition, is concerning with various actions adopted a person to acquire, use and dispose of consumer goods services, including the decision-making process that precedes determines these actions. In real practice, such behavior can be altered introduction internet-based financing services. Especially for college students, who have relatively weak knowledge personal finance insufficient vigilance excessive consumption, their consumption easily manipulated service...
Contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) has been used in the differential diagnosis of benign and malignant tumors by visualization tumor microcirculation perfusion. However, its diagnostic role submucosal (SMTs), especially leiomyomas gastric (GISTs) was rarely studied. The aim this study to analyze CEH-EUS for SMTs (<50 mm) value assessing potential GISTs.We retrospectively included patients with <50 mm diameter who underwent preoperative EUS examination had...
With the speedy development of sequencing technologies, noninvasive prenatal testing (NIPT) has been widely applied in clinical practice for fetal aneuploidy. The cell-free DNA (cffDNA) concentration maternal plasma is most critical parameter this technology because it affects accuracy NIPT-based trisomies 21, 18 and 13. Several approaches have developed to calculate cffDNA fraction total plasma. However, depend on specific single nucleotide polymorphism (SNP) allele information or are...