A5100345718- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Nutritional Studies and Diet
- Assisted Reproductive Technology and Twin Pregnancy
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Intergenerational Family Dynamics and Caregiving
- Blood groups and transfusion
- Demographic Trends and Gender Preferences
- Fetal and Pediatric Neurological Disorders
- Metabolomics and Mass Spectrometry Studies
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Cancer Risks and Factors
- Neonatal Health and Biochemistry
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Parvovirus B19 Infection Studies
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
Heilongjiang Center for Tuberculosis Control and Prevention
2021-2024
Shenzhen Luohu People's Hospital
2023-2024
Shenzhen University
2023-2024
Wenzhou Medical University
2022
Weatherford College
2021
First Affiliated Hospital of Zhengzhou University
2021
Henan University
2021
Anhui Provincial Children's Hospital
2019
XinHua Hospital
2015-2018
Shanghai Jiao Tong University
2015-2017
This study demonstrates noninvasive prenatal testing (NIPT) for Duchenne muscular dystrophy (DMD) using a newly developed haplotype-based approach.Eight families at risk DMD were recruited this study. Parental haplotypes constructed target-region sequencing data from the parents and probands. Fetal hidden Markov model through maternal plasma DNA sequencing. The presence of linked to mutant alleles in males indicated affected fetuses. method was further validated by comparing inferred...
Background: The study aimed to investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) and risk of incident hypertension, especially concerning different levels low-density (LDL-C) non-HDL-C with hypertension. Methods: A total 10,623 participants from Rural Chinese Cohort Study were included in analyses. Non-HDL-C is blood minus high-density (HDL-C). odds ratios (ORs) 95% confidence intervals (95% CIs) non-HDL-C, LDL-C, hypertension estimated using logistic...
Background Recent surveillance data suggest that mean birth weight has begun to decline in several developed countries. The aim of this study is examine the changes among singleton live births from 2002 2012 Guangzhou, one most rapidly cities China. Methods We used Guangzhou Perinatal Health Care and Delivery Surveillance System for 34108 54575 with 28–41 weeks gestation, who were born local mothers, 2012, respectively. trends weight, small (SGA) large (LGA) gestational age length explored...
BACKGROUNDAnti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice.Recent change national population policy has followed by an increase related hemolytic disease newborn (HDN).Unfortunately, regional status Rh-HDN unavailable.We hypothesize that our region most commonly due to anti-E antibody. AIMTo investigate prevalence Rhisoimmunization Hefei City.
Infertile women with diminished ovarian reserve (DOR) confront an increased miscarriage rate in assisted reproductive technology (ART). Genetic abnormality is the most important factor. However, effects of DOR and female age on molecular karyotype products conception (POCs) remain unknown. We analyzed POCs using a single nucleotide polymorphism (SNP) microarray from who experienced first-trimester IVF/ICSI cycles. The SNP revealed chromosomal abnormalities 74.6% (47/63) POCs, including...
Background: The association between educational attainment (EA) and offspring birth weight (BW) has been reported by several traditional epidemiological studies. However, evidence for this tends to be mixed confounded. This study aimed investigate the causal EA of parents BW. Methods: Here, we carried out a two-sample bidirectional Mendelian randomization (MR) analysis examine males (n = 131,695) females 162,028) BW using genetic instruments. Summary statistics associated single nucleotide...
We aimed to explore whether and what extent overweight or obesity could increase the risk of hypertension, further estimate roles genetic early-life familial environmental factors in their association.This prospective twin study was based on Chinese National Twin Registry (CNTR), which collected information from self-report questionnaires. conducted unmatched case-control analysis examine association between hypertension. And genetics familiar environments shared within a pair, accounted for...
Abstract We aimed to investigate the association of metabolic obesity phenotypes with all-cause mortality risk in a rural Chinese population. This prospective cohort study enrolled 15 704 adults (38·86 % men) median age 51·00 (interquartile range: 41·00–60·00) at baseline (2007–2008) and followed up during 2013–2014. Obesity was defined by waist circumference (WC: ≥ 90 cm for men 80 women) or waist-to-height ratio (WHtR: 0·5). The hazard (HR) 95 CI related were calculated using Cox hazards...
Abstract Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the contributions on these clocks change with age may provide novel insights into In this study, based 1084 adult twins from Chinese National Twin Registry (CNTR), we established structural equation models (SEMs) to evaluate trends in influence for epigenetic which include PC‐Horvath, PC‐Hannum, PC‐PhenoAge,...
Abstract The aim of the present study was to compare rate preterm birth (PTB) and growth from 18 years between twins conceived by in vitro fertilization (IVF) spontaneous conception (SC) mainland China. retrospective cohort included 1164 resulting IVF 25,654 spontaneously, which 494 6338 SC were opposite-sex twins. PTB low weight (LBW), growth, including length/height weight, compared two groups at five stages: infancy (0 year), toddler period (1–2 years), preschool (3–5 primary or...
Abstract This study aimed to evaluate the clinical characteristics, pregnancy outcomes and prognostic factors for of female with chromosomal abnormalities (CAs) after artificial insemination donor's sperm (AID) treatment. A retrospective case–control was analyzed by using data 29 patients CA 116 controlled normal karyotype (1:4 ratio) who underwent AID cycles at Guangdong Family Planning Special Hospital from January 2011 December 2017. In all cases, reproductive histories were collected,...
Objective To estimate prenatal diagnoses strategy with abnormal results of non-invasive testing (NIPT) based on a case mosaic for trisomy 22. Methods The pregnanct woman was recruited from Department Prenatal Diagnosis Center Xinhua Hospital. Ultrasound scans suggested fetal nuchal translucency 3.5 mm. Peripheral venous blood drawn the pregnant NIPT at 12+ 2 weeks gestation. For further diagnosis, amniocentesis conducted 16+ gestation, and karyotype analysis combination chromosome...