A5103233116- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Chronic Disease Management Strategies
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- Climate Change and Health Impacts
- Cardiovascular Health and Risk Factors
- Injury Epidemiology and Prevention
- Multiple Sclerosis Research Studies
- Healthcare Systems and Reforms
- Pharmacological Effects of Natural Compounds
- Traffic and Road Safety
- Myasthenia Gravis and Thymoma
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
- Health Promotion and Cardiovascular Prevention
- Chemokine receptors and signaling
- Prenatal Substance Exposure Effects
- Cell death mechanisms and regulation
- Medication Adherence and Compliance
- Hepatitis Viruses Studies and Epidemiology
Peking University
2006-2025
Zhejiang Center for Disease Control and Prevention
2013-2025
Guangzhou Medical University
2024
Sichuan University
2020-2024
Fudan University
2019-2024
University of Kentucky
2018-2023
Second Affiliated Hospital of Zhejiang University
2023
West China Hospital of Sichuan University
2020-2022
Soochow University
2022
Soochow University
2020
Background systemic inflammation disorders were observed in chronic kidney disease (CKD). Whether the inflammatory indicators could be optimal predictors for survival of CKD remains less studied. Methods In this study, participants selected from datasets National Health and Nutrition Examination Survey (NHANES) between 1999 to 2018 years. Four evaluated by peripheral blood tests including immune-inflammation index (SII, platelet*neutrophil/lymphocyte), neutrophil-to-lymphocyte ratio (NLR),...
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Most patients undergo initial relapsing-remitting (RR-MS) course that transforms into a relentless neurodegenerative disorder, termed secondary progressive (SP)-MS. Reversible inflammation and demyelination account readily for pattern RR-MS but provide unsatisfactory explanation irrevocable decline in SP-MS. Axon loss thought to be responsible progressive, non-remitting neurological...
The development of autoimmune disease is accompanied by the acquired recognition new self-determinants, a process commonly referred to as determinant spreading. In this study, we addressed question whether spreading pathogenic for progression chronic-relapsing experimental encephalomyelitis (EAE), with many similarities multiple sclerosis (MS). Our approach involved systematic epitope mapping responses myelin proteolipid protein (PLP) well assaying known encephalitogenic determinants basic...
We have previously used antibodies to the NG2 proteoglycan and alpha receptor for platelet-derived growth factor (PDGF α receptor) identify oligodendroglial progenitor cells in vivo vitro. It has recently become evident that GD3 antigen, which been widely as a marker oligodendrocyte cells, is also expressed by microglial cells. In this study we examined relationship between NG2+/PDGF receptor+ glial normal developing mature rat brain inflammatory lesions mice with experimental autoimmune...
Background The likely corresponding increase in prevalence of chronic disease will be a major challenge for the health care system. Few nationwide epidemiological studies include large enough sample older adults to provide estimates conditions adult population. This study aimed estimate eight common and examine socioeconomic inequalities diseases among China. Method Data are from SAGE-China Wave 1, including 13,157 people aged 50-plus years. Respondents were asked if they had been diagnosed...
Abstract Maxillofacial bone defects caused by trauma, infections, tumors, and congenital disorders have become a significant global health concern. An ideal guided regeneration (GBR) membrane is expected to not only act as barrier but also promote osteoinduction osteogenesis. However, non‐resorbable membranes limited bioactivity require secondary surgeries, whereas resorbable often lack the required mechanical properties degrade too quickly. To address these challenges, bilayer self‐induced...
The migratory properties of memory T cells provide a model vector system for site-specific delivery therapeutic transgene factors to autoimmune inflammatory lesions. Lymph node from (SWRxSJL)F1 mice immunized with the p139-151 determinant myelin proteolipid protein (PLP) were transfected DNA construct that placed anti-inflammatory cytokine interleukin-10 (IL-10) cDNA under control an antigen-inducible IL-2 promoter region. Isolated cell clones demonstrated expression IL-10 and expressed...
Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis (MS). EAE typically initiated by CD4+ T helper cell type 1 (Th1) autoreactivity directed against single priming immunodominant myelin peptide determinant. Recent studies have shown that clinical progression of involves the accumulation neo-autoreactivity, commonly referred to as epitope spreading, determinants not involved in process. This study directly addresses relative roles primary and...
Engineering a complete, physiologically functional, periodontal complex structure remains great clinical challenge due to the highly hierarchical architecture of periodontium and coordinated regulation multiple growth factors required induce stem cell multilineage differentiation. Using biomimetic self-assembly microstamping techniques, we construct bilayer consisting intrafibrillarly mineralized collagen resembling bone cementum, unmineralized parallel-aligned fibrils mimicking ligament....
The single and/or combination use of immune checkpoint blockade therapies in human infectious diseases and cancer are rapidly expanding. Despite early efforts, substantial uncertainty remains about the safety efficacy some populations. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) T-cell immunoglobulin mucin-3 (Tim-3) major targetable co-inhibitory receptors on T cells. Here we showed that animal studies, treatment with either CTLA-4- or Tim-3-blocking antibody caused greater...
Entamoeba infection-associated diseases (EIADs) in humans are a worldwide public health problem, but there is lack of global picture EIADs, which vital to prevention and control. We applied 2019 Global Burden Disease (GBD) data collected from multiple sources at global, national regional levels. The disability-adjusted life years (DALYs) with corresponding 95% uncertainty intervals (95% UIs) were extracted as the main measure burden EIADs. Joinpoint regression model was used estimate trends...
Objective: To describe the distribution characteristics of alcohol consumption in adult twins Chinese National Twin Registry (CNTR), and further explore influence genetic factors on twins. Methods: The subjects study were registered by CNTR 11 project areas across China from 2010 to 2018. A total 56 966 (28 483 pairs) aged 18 years above who answered questions about drinking behavior included, random effect model was used population regional consumption. Intra-pair analysis performed...
With global warming, several previous studies have examined the effect of compound hot extreme on mortality. However, there were little evidence associations cold (CCE) with Daily meteorological factors, air pollutants and non-accidental mortality data during seasons (Nov. to Mar.) 2006-2017 collected from 364 counties/districts in China. CCE was defined as a night following day. Distributed lag non-linear model (DLNM) first used examine association between at county/district level. Then,...
Objective: This study aimed to explore the relationship between breakfast consumption frequency and both depression anxiety symptoms among middle high school students in Eastern China. Methods: In this school-based cross-sectional study, 27,001 were investigated 2022. Multivariable logistic regression models used examine symptoms. Results: The percentages of who consumed daily, 6 days/week, 4-5 ≤3 days/week 71.0% (95%CI: 69.9-72.2), 8.3% 7.8-8.6), 11.9% 11.2-12.6), 8.8% 8.2-9.5),...
Objective: To evaluate the impact of short-term exposure to daytime heatwaves, nighttime and compound heatwaves on risk road traffic mortality calculate attributable burden. Methods: This study collected data from Disease Surveillance System in Guangdong, Hunan, Zhejiang, Yunnan, Jilin Provinces 2013 2018. A time-stratified case-crossover design was used this study, with death date for each case serving as day. Control days were selected same year, month, day week conditional logistic...
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which there are no reliable biomarkers or disease-modifying drugs. Here, we integrated human genomics and proteomics to investigate the causal associations between 2769 plasma proteins IPF. Our Mendelian randomisation analysis identified nine associated with IPF, of three (FUT3, ADAM15 USP28) were colocalised. emerged as top candidate, supported by expression quantitative trait locus in both blood tissue. These findings provide...
Objective: To evaluate the association between heatwaves and fall-related mortality. Methods: A total of 61 421 mortality from 2013 to 2022 in 7 provinces China were included a time-stratified case-crossover design, with daily meteorological data derived fifth generation European Reanalysis dataset produced by Centre for Medium-Range Weather Forecasts. Conditional logistic regression chimeric distributed lag nonlinear model was used analyze stratified analysis conducted according gender age....
Objective: To explore the risk fall death associated with compound hot extremes. Methods: This study collected data on deaths in Guangdong, Hunan, and Zhejiang Provinces from 2013 to 2018 matched their exposure meteorological data. Based a time-stratified case-crossover design, conditional logistic regression model embedded cross-basis function of distributed lag nonlinear was applied estimate due Results: Compared regular days, extremes significantly increased falls (OR=1.19, 95%CI:...
In this paper, a previous tumour–immune interaction model is simplified by neglecting relatively weak direct immune activation the tumour cells, which can still keep essential dynamics properties of original model. As process not instantaneous, we now incorporate one delay for effector cells (ECs) helper T (HTCs) into Furthermore, investigate stability and instability regions tumour-presence equilibrium state delay-induced system with respect to two parameters, rate ECs HTCs stimulation...
Objective This study aims to assess whether a standard intervention package of cardiovascular disease (CVD) care was being delivered effectively, and if it associated with improved lifestyle biomedical indicators. Methods In rural China, we implemented pragmatic cluster randomized controlled trial for 12 months, at the township hospital level, compared usual care. Intervention case management guideline, training performance monitoring meeting patient support activities were designed fit...