A5005246216- Pancreatic and Hepatic Oncology Research
- Science, Research, and Medicine
- Lung Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Air Quality and Health Impacts
- Cancer, Lipids, and Metabolism
- COVID-19 impact on air quality
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Climate Change and Health Impacts
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- Lipoproteins and Cardiovascular Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
National Cheng Kung University Hospital
2025
Keck Hospital of USC
2021-2024
University of Southern California
2019-2024
Universität Ulm
2024
Allen Institute for Brain Science
2024
Johns Hopkins University
2013-2024
USC Norris Comprehensive Cancer Center
2024
Hospital of the University of Pennsylvania
2023
Penn Center for AIDS Research
2023
Purdue University West Lafayette
2023
Rationale: Most lung cancers are diagnosed at an advanced stage. Presymptomatic identification of high-risk individuals can prompt earlier intervention and improve long-term outcomes. Objectives: To develop a model to predict future diagnosis cancer on the basis routine clinical laboratory data by using machine learning. Methods: We assembled from 6,505 case patients with non-small cell (NSCLC) 189,597 contemporaneous control subjects compared accuracy novel learning modified version...
Rationale: Ecological studies have shown air pollution associations with coronavirus disease (COVID-19) outcomes. However, few cohort been conducted. Objectives: To conduct a study investigating the association between and COVID-19 severity using individual-level data from electronic medical record. Methods: This included all individuals who received diagnoses of Kaiser Permanente Southern California March 1 August 31, 2020. One-year 1-month averaged ambient pollutant (particulate matter...
Prior observational studies suggest an association between intra-pancreatic fat deposition (IPFD) and pancreatic ductal adenocarcinoma (PDAC); however, the causal relationship is unclear. To elucidate causality, we conduct a prospective study using magnetic resonance imaging (MRI)-measured IPFD data also perform Mendelian randomization genetic instruments for IPFD. In study, use UK Biobank (N = 29,463, median follow-up: 4.5 years) find that high (>10%) associated with PDAC risk (adjusted...
Background: Although advanced pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive weight loss and nutritional deterioration, the effect of cancer cachexia body mass index (BMI) at diagnosis on survival remains unclear. Methods: We retrospectively evaluated a prospectively collected internal registry PDAC cases from 2006–2014 Kaiser Permanente Medical Center. Cancer was defined as greater than 5% over 6 months prior to diagnosis. Multivariate cox proportional hazards...
Facilitating the development of alternative targeted therapeutic strategies is urgently required to improve outcome or circumvent chemotherapy resistance in children, adolescents, and adults with recurrent/refractory de novo mature B-cell (CD20) non-Hodgkin lymphoma, including Burkitt lymphoma (BL). Romidepsin, a histone deacetylase inhibitor (HDACi), has been used treat cutaneous T-cell lymphoma. We have demonstrated significant anti-tumor effect anti-CD20 chimeric antigen receptor (CAR)...
Recent studies have suggested associations between statins and enhanced survival among patients with pancreatic ductal adenocarcinoma (PDAC). However, the relationship statins, cholesterol, remains unclear.We conducted a retrospective cohort study on 2142 PDAC in regional integrated healthcare system from 2006 to 2014. Electronic pharmacy records were used abstract information type, length, dosage of statin exposures starting year prior diagnosis. The cumulative individual effects...
It has been suggested that statins exert potential anti-tumor effects. The relationship between statin use and outcomes in pancreatic cancer is controversial. We hypothesized at baseline would impact survival among patients with early-stage the effect might vary by individual agent.We conducted a retrospective cohort study on data from an integrated healthcare system. included stage I-IIb who underwent resection for curative intent January 2005 2011. Baseline was characterized as any prior...
Abstract While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined other ethnic minorities. We evaluated variations assessed the extent to which known risk factors account for differences among African Americans, Native Hawaiians, Japanese Latino European Americans Multiethnic Cohort Study. Risk factor data were obtained from baseline questionnaire. Cox regression was used estimate relative risks (RRs) 95% confidence intervals (CIs)...
Transcranial focused ultrasound stimulation (tFUS) is a noninvasive neuromodulation technique, which can penetrate deeper and modulate neural activity with greater spatial resolution (on the order of millimeters) than currently available brain methods, such as transcranial magnetic (TMS) direct current (tDCS). While there are several studies demonstrating ability tFUS to neuronal activity, it unclear whether be used for producing long-term plasticity needed modify circuit function,...
INTRODUCTION: Recent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear. METHODS: Using Mendelian randomization, we evaluated association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide (n = 25,617), acute pancreatitis 6,787 cases/361,641 controls), chronic 3,875 controls). RESULTS: Genetically was significantly associated (odds ratio per 1-SD...
With the development of military technology, mechanisms used in equipment require higher reliability and longer lifespans. Addressing challenge ensuring long lifespan connecting rod difficulty conducting durability tests on each model, this paper analyzes under reciprocating operating conditions using fault physics finite element methods. Additionally, sensitivity mechanism parameters is examined, providing valuable engineering references for design mechanisms.
Little information is available on how active adult patients are during their hospitalization. The purpose of this study to describe the level ambulation in hospitalized patients. This was a cohort ambulatory from 3 hospital medical-surgical units conducted March 2014 through July 2014. Patients wore an accelerometer upon admission unit until discharge home. Sensor placement and data review were performed as part routine care. Step counts merged with administrative clinical for analysis....
Mouse models have demonstrated utility in delineating the mechanisms underlying many aspects of malaria immunology and physiology. The most common mouse employ rodent-specific parasite species Plasmodium berghei, P. yoelii, chabaudi, which elicit distinct pathologies immune responses are used to model different manifestations human disease. In vitro culture methods not well developed for rodent parasites, thus require vivo maintenance. Moreover, physiologically relevant immunological...
Air pollution exposure has been associated with increased risk of COVID-19 incidence and mortality by ecological analyses. Few studies have investigated the specific effect traffic-related air on severity.To investigate associations near-roadway (NRAP) severity using individual-level outcome data.The retrospective cohort includes 75,010 individuals (mean age 42.5 years, 54% female, 66% Hispanic) diagnosed at Kaiser Permanente Southern California between 3/1/2020-8/31/2020. NRAP exposures...
Previous retrospective studies have shown that chimeric antigen receptor T (CAR-T) cell therapy may be associated with major adverse cardiovascular events (MACE), especially in the context of cytokine-release syndrome (CRS) events.
In harem-polygynous societies, body condition is often correlated with dominance rank. However, the consequences of are less clear. High-ranking males do not inevitably have highest reproductive success, especially in systems where females mate multiple males. such we expect male success to be more highly skewed than female but skew can still arise from rankings established within matrilineal societies. Dominance also impact life-history decisions by influencing dispersal patterns yearlings....