A5042819463- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Virus-based gene therapy research
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- CRISPR and Genetic Engineering
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Transcranial Magnetic Stimulation Studies
- Ultrasound and Hyperthermia Applications
Johns Hopkins Medicine
2019-2024
Allen Institute for Brain Science
2019-2024
Johns Hopkins University
2019-2024
New York University
2023
National Institute of Neurological Disorders and Stroke
2015-2016
National Institutes of Health
2016
Transcranial focused ultrasound stimulation (tFUS) is a noninvasive neuromodulation technique, which can penetrate deeper and modulate neural activity with greater spatial resolution (on the order of millimeters) than currently available brain methods, such as transcranial magnetic (TMS) direct current (tDCS). While there are several studies demonstrating ability tFUS to neuronal activity, it unclear whether be used for producing long-term plasticity needed modify circuit function,...
The mammalian olfactory bulb (OB) displays robust activity-dependent plasticity throughout life. Dopaminergic (DA) neurons in the glomerular layer (GL) of OB are particularly plastic, with loss sensory input rapidly reducing tyrosine hydroxylase (TH) expression and dopamine production, followed by a substantial reduction DA neuron number. Here, we asked whether microglia participate elimination mouse OB. Interestingly, found significant number both their synapses ipsilateral to occluded...
The ability to label and manipulate specific cell types is central understanding the structure function of neuronal circuits. Here, we have developed a simple, affordable strategy for labeling genetically defined populations neurons throughout targeted brain region: Bulk Regional Viral Injection (BReVI). Our involves large volume adeno-associated virus (AAV) injection in region neonatal Cre driver mice. Using mouse olfactory bulb (OB) as model system, tested BReVI broadly selectively tufted...
Abstract Somatostatin-positive (SOM) interneurons are integral for shaping cortical processing and their dynamic recruitment is likely necessary adaptation to sensory experience contextual information. We found that excitatory synapses on SOMs in layer 2/3 (L2/3) of primary visual cortex (V1) mice can be categorized into fast (F)- slow (S)-Types based the kinetics AMPA receptor-mediated current. Each SOM contains both types varying proportions. The majority local pyramidal neurons (PCs) make...
The history of neural activity determines the synaptic plasticity mechanisms employed in brain. Previous studies report a rapid reduction strength excitatory synapses onto layer 2/3 (L2/3) pyramidal neurons primary visual cortex (V1) following two days dark exposure and subsequent re-exposure to light. abrupt increase visually driven is predicted drive homeostatic plasticity, however, parameters that trigger these changes are unknown. To determine this, we first recorded spike trains vivo...