A5072531261- Advanced Memory and Neural Computing
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Intelligent Tutoring Systems and Adaptive Learning
- Endoplasmic Reticulum Stress and Disease
- Photoacoustic and Ultrasonic Imaging
- Cognitive Science and Mapping
- Multisensory perception and integration
- Ultrasound and Hyperthermia Applications
- Visual perception and processing mechanisms
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Tactile and Sensory Interactions
Johns Hopkins Medicine
2022-2024
Johns Hopkins University
2021-2024
Allen Institute for Brain Science
2021-2024
Cold Spring Harbor Laboratory
2016-2017
Abstract Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but how disruption of experience-dependent plasticity contributes to cognitive and behavioural decline adulthood is unclear. Here we show that pup gathering behaviour associated auditory cortical impaired female Mecp2 het mice, a model Rett syndrome. In response learned maternal experience, females exhibited transient changes inhibitory networks typically with limited plasticity. Averting...
Transcranial focused ultrasound stimulation (tFUS) is a noninvasive neuromodulation technique, which can penetrate deeper and modulate neural activity with greater spatial resolution (on the order of millimeters) than currently available brain methods, such as transcranial magnetic (TMS) direct current (tDCS). While there are several studies demonstrating ability tFUS to neuronal activity, it unclear whether be used for producing long-term plasticity needed modify circuit function,...
Cortical areas are highly interconnected both via cortical and subcortical pathways, primary sensory cortices not isolated from this general structure. In areas, these pre-existing functional connections serve to provide contextual information for processing can mediate adaptation when a modality is lost. Cross-modal plasticity in broad terms refers widespread across the brain response losing modality, largely involves two distinct changes: cross-modal recruitment compensatory plasticity....
Sensory loss leads to widespread cross-modal plasticity across brain areas allow the remaining senses guide behavior. While multimodal sensory interactions are often attributed higher-order areas, has been observed at level of synaptic changes even primary cortices. In particular, vision circuit adaptation in auditory cortex (A1) adults. Here we report using mice both sexes which occurs earlier sensory-processing pathway thalamus a modality-selective manner. A week visual deprivation reduced...
ABSTRACT Neurodevelopmental disorders begin with the emergence of inappropriate synaptic connectivity early in life, yet how sustained disruption experience-dependent plasticity aggravates symptoms adulthood is unclear. Here we used pup retrieval learning to assay adult cortical a female mouse model Rett syndrome ( MeCP2 het ). We show that auditory and are impaired . Specifically, normal MECP2 expression cortex required for efficient learning. In wild-type mice, cohabitation mother her pups...
Dendritic spines are structural correlates of excitatory synapses maintaining stable synaptic communications. However, this strong spine-synapse relationship was mainly characterized in pyramidal neurons (PyNs), raising a possibility that inferring density from dendritic spine number may not be universally applied to all neuronal types. Here we found the ectopic expression H-Ras increased numbers regardless cortical cell types such as layer 2/3 parvalbumin (PV)- and vasoactive intestinal...