A5076027451- Pancreatitis Pathology and Treatment
- Nutrition, Genetics, and Disease
- Global Cancer Incidence and Screening
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Obesity and Health Practices
- Digestive system and related health
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Lipid metabolism and biosynthesis
- Cardiovascular Health and Risk Factors
- Glutathione Transferases and Polymorphisms
- Genetic factors in colorectal cancer
- Genetic Syndromes and Imprinting
- Diet, Metabolism, and Disease
- FOXO transcription factor regulation
- Birth, Development, and Health
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Cardiovascular Disease and Adiposity
- Cholesterol and Lipid Metabolism
- Diabetes and associated disorders
University of Hawaiʻi at Mānoa
2021-2024
Cancer Center of Hawaii
2024
University of Hawaii System
2024
University of Hawaii Cancer Center
2021-2024
Kyoto University
2024
Uniformed Services University of the Health Sciences
2020-2022
Henry M. Jackson Foundation
2020-2022
Yale University
2012
National Institutes of Health
2002
INTRODUCTION: Recent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear. METHODS: Using Mendelian randomization, we evaluated association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide (n = 25,617), acute pancreatitis 6,787 cases/361,641 controls), chronic 3,875 controls). RESULTS: Genetically was significantly associated (odds ratio per 1-SD...
Previous research has found that milk is associated with a decreased risk of colorectal cancer (CRC). However, it unclear whether the digestion by enzyme lactase-phlorizin hydrolase (LPH) plays role in CRC susceptibility. Our study aims to investigate direct causal relationship LPH levels applying two-sample Mendelian Randomization (MR) strategy. Genetic instruments for were derived from Fenland Study, and CRC-associated summary statistics these extracted FinnGen PLCO Atlas Project, Pan-UK...
<b><i>Background:</i></b> New genetic associations with obesity are rapidly being discovered. People's causal beliefs about may influence their obesity-related behaviors. Little is known compared to lifestyle regarding obesity, and diseases, among minority populations. This study examined 3 diseases a low-income, ethnically diverse patient sample. <b><i>Methods:</i></b> Structured interviews were conducted patients attending an inner-city...
Abstract Context The distribution of body fat has been linked to circulating levels lipids and sex steroid hormones. cholesterol metabolite endogenous selective estrogen receptor modulator, 27-hydroxychlolesterol (27HC), may be influenced by adiposity phenotypes, particularly among females. No study examined the relationships 27HC with phenotypes. Objective To investigate associations hormones detailed phenotypes a multiethnic population postmenopausal women. Methods A cross-sectional was...
Abstract Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent joint roles of patient race location on biochemical recurrence‐free (BCR) survival. Methods A retrospective cohort was conducted among men with newly diagnosed, biopsy‐confirmed, NCCN‐defined low risk CaP who underwent radical prostatectomy (RP) at Walter Reed National Military Medical Center from 1996 to 2008. modeled using Kaplan‐Meier...
Few studies have explored the genetic underpinnings of intra-abdominal visceral fat deposition, which varies substantially by sex and race/ethnicity. Among 1,787 participants in Multiethnic Cohort (MEC)-Adiposity Phenotype Study (MEC-APS), we conducted a genome-wide association study (GWAS) percent adiposity tissue (VAT) area out overall abdominal area, averaged across L1-L5 (%VAT), measured magnetic resonance imaging (MRI). A significant signal was found on chromosome 2q14.3 sex-combined...
Abstract Background Previous research exploring the role of race on prostate cancer (PCa) outcomes has demonstrated greater rates disease progression and poorer overall survival for African American (AA) compared to Caucasian (CA) men. The current study examines self‐reported as a predictor long‐term PCa in patients with low favorable‐intermediate risk treated external beam radiation therapy (EBRT). Methods This retrospective cohort examined who were consented enrollment Center Prostate...
Abstract Background There is substantial variability in prostate cancer (PCa) mortality rates across Caucasian American (CA), African (AA), Asian, and Hispanic men; however, these estimates are unable to disentangle race or ethnicity from confounding factors. The current study explores survival differences long‐term PCa outcomes between self‐reported AA CA men, examines clinicopathologic features CA, AA, men. Methods This retrospective cohort utilized the Center for Prostate Disease Research...
Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes the metabolic syndrome, but investigations into genetic contributions to are limited. This genome-wide association study, comprised of 804 participants with MRI-assessed measurements, was conducted in ethnically diverse Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS). Two variants reaching significance, rs73449607 on chromosome 13q21.2 (Beta = -0.67, P 4.50x10 -8...
Abstract Differences in chronic disease rates have been documented Japan between Okinawa and mainland Japan. Limited data exist on whether these differences are also present Okinawans Japanese who migrated to the US. We used genotyped genome-wide association study from Multiethnic Cohort Study (MEC) identify Americans of Okinawan or ancestral similarity, investigate two groups for baseline risk factors incidence four most common cancers during follow-up after blood draw. Cancer cases were...
Abstract Background: Colorectal cancer (CRC) ranks as the third most common worldwide. Despite its established connection with genetic, dietary, and lifestyle factors, gaps remain in understanding of etiology. Lactase-phlorizin hydrolase (LPH) plays a critical role milk digestion influences crucial nutrient absorption gut microbiota composition. A direct relationship CRC risk LPH level remains unexplored. Our study aims to elucidate potential causal link between genetically determined levels...
Recent associative studies have linked intra-pancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear.
Abstract Jews are estimated to be at increased risk of pancreatic cancer compared non-Jews. The higher in can partially explained by the frequency BRCA1 and BRCA2 mutations Ashkenazi Jewish population; however, remaining 40-70% excess is not other established non-genetic genetic factors. origins modern traced back a founder population bottleneck between 11th 15th centuries follow rapid endogamous expansion, making isolate ideal for exploring contributions cancer. We conducted genome-wide...
Abstract Several studies have found associations between higher pancreatic fat content and adverse health outcomes, such as diabetes the metabolic syndrome, but investigations into genetic contributions to are limited. This genome-wide association study, comprised of 804 participants with MRI-assessed measurements, was conducted in ethnically diverse Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS). Two variants reaching significance, rs73449607 on chromosome 13q21.2 (Beta = −0.67, P...