A5057390904- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Global Cancer Incidence and Screening
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- MRI in cancer diagnosis
- Coronary Interventions and Diagnostics
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Vitamin D Research Studies
- Bladder and Urothelial Cancer Treatments
- Cardiac Imaging and Diagnostics
- Cerebrovascular and genetic disorders
George Washington University Hospital
2023-2025
Washington DC VA Medical Center
2025
Memorial Sloan Kettering Cancer Center
2025
George Washington University
2024
Uniformed Services University of the Health Sciences
2018-2022
Walter Reed National Military Medical Center
2021
Semmelweis University
2013
Background: Next-generation sequencing has revealed TP53 alterations in localized prostate cancer (PCa), suggesting growing clinical potential for p53 immunohistochemistry (IHC). Prior research supports the use of IHC detection overexpression to predict presence known be associated with adverse outcomes. However, reach a consensus definition PCa, further insights are needed. This study aimed compare two fundamental approaches evaluating expression across variety specimens regarding PCa...
TP53 is one of the most frequently altered genes in prostate cancer. The precise assessment its focal alterations primary tumors by immunohistochemistry (IHC) has significantly enhanced prognosis. p53 protein expression and lymphovascular invasion (LVI) were evaluated for predicting metastatic progression IHC staining representative whole-mounted sections from a cohort 189 radical prostatectomy patients with up to 20 years clinical follow-up. Kaplan-Meier survival curves used examine time...
Background Although prostate MRI is routinely used for the detection and staging of localized cancer, imaging-based assessment targeted molecular sampling risk stratification are an active area research. Purpose To evaluate features preoperative MRI-guided biopsy immunohistochemistry (IHC) findings associated with biochemical recurrence (BCR) cancer after surgery. Materials Methods In this retrospective case-control study, patients underwent multiparametric before followed by radical...
Abstract Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent joint roles of patient race location on biochemical recurrence‐free (BCR) survival. Methods A retrospective cohort was conducted among men with newly diagnosed, biopsy‐confirmed, NCCN‐defined low risk CaP who underwent radical prostatectomy (RP) at Walter Reed National Military Medical Center from 1996 to 2008. modeled using Kaplan‐Meier...
Leptomeningeal metastasis (LMM) is a rare complication of non-small cell lung cancer (NSCLC) that can present with range neurological symptoms depending on the site(s) metastatic involvement. We case 54-year-old woman who was initially diagnosed suspected inflammatory neuritis secondary to known systemic lupus erythematosus (SLE) diagnosis after presenting multiple months progressive neuro-ophthalmologic symptoms; however, she eventually LMM previously undiagnosed NSCLC. This both...
217 Background: Increased utilization of next-generation sequencing has revealed evidence early TP53 alterations in localized prostate cancer (PCa), suggesting a growing clinical potential for p53 immunohistochemistry (IHC). Prior research by Harmon and Gesztes et al. (Radiology, 2021 & Scientific Reports, 2022) support the utility detecting overexpression core biopsies radical prostatectomies (RP) to predict underlying alterations, biochemical recurrence (BCR), metastasis. However,...
You have accessJournal of UrologyProstate Cancer: Markers III1 Apr 2017PD71-11 P53 FOCAL PROTEIN EXPRESSION IN PRIMARY PROSTATE TUMORS AND LYMPHATIC VESSEL INVASION PREDICT BIOCHEMICAL RECURRENCE METASTATIC PROGRESSION William Gesztes, Jennifer Cullen, Denise Young, Yongmei Chen, Allen Burke, Albert Dobi, Gyorgy Petrovics, Inger Rosner, Shiv Srivastava, and Isabell Sesterhenn GesztesWilliam Gesztes More articles by this author , CullenJennifer Cullen YoungDenise Young ChenYongmei Chen...
Abstract Purpose: Building on previous work, this study examined the independent role of ERG staining pattern in index prostate cancer (CaP) tumor, probability upstaging and biochemical recurrence (BCR) following radical prostatectomy (RP). Methods: A retrospective cohort patients enrolled at Walter Reed National Military Medical Center who underwent RP between 1993 2016 was conducted. oncoprotein expression assessed CaP tumors (i.e., largest poorest grade) using immunohistochemistry (IHC)...
Abstract Purpose: To assess the correlation of histologic and prostate cancer associated gene oncoprotein expression imaging features in MRI-detected lesions patients with biochemical recurrence (BCR) after definitive treatment. Methods: Patients underwent multiparametric MRI (mpMRI) at 3T a single institution prior to TRUS/MRI fusion-guided biopsy MRI-defined index therapy (radical prostatectomy), for which clinical follow-up was available. All mpMRI were prospectively scored low, moderate,...
e17065 Background: Prostate cancer (CaP) tumor location (TL) and symmetry (TS) may help forecast CaP outcomes in radical prostatectomy (RP) patients. The study aim was to examine associations between TL & TS with disease pathology progression including whether such differ across race. Methods: This retrospective cohort included 1140 patients enrolled at the Walter Reed National Military Medical Center who underwent RP 1993 - 2008. were recorded for index tumors (ie largest/highest grade)...
Introduction and objectiveProstate cancer (CaP) tumor location (TL) symmetry (TS), may help forecast CaP outcomes in radical prostatectomy (RP) patients. The study aim was to examine associations between TL TS with disease pathology progression, including biochemical recurrence (BCR)-free survival especially whether such differ across race.MethodsThis retrospective cohort included 1140 patients enrolled at the Walter Reed National Military Medical Center who underwent RP 1993 2008. were...
Abstract Introduction and objective Prostate cancer (CaP) tumor location (TL) symmetry (TS), may help forecast CaP outcomes in radical prostatectomy (RP) patients. The study aim was to examine associations between TL TS with disease pathology progression, including biochemical recurrence (BCR)-free survival especially whether such differ across race. Methods This retrospective cohort included 1140 patients enrolled at the Walter Reed National Military Medical Center who underwent RP 1993...