A5020234995- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Metal-Catalyzed Oxygenation Mechanisms
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Urological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Molecular Biology Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Genital Health and Disease
- Lung Cancer Research Studies
- Global Cancer Incidence and Screening
Memorial Sloan Kettering Cancer Center
2016-2025
Michigan Medicine
2014-2022
NorthShore University HealthSystem
2022
University of Chicago Medical Center
2022
Cleveland Clinic
2013-2022
Universidad de Londres
2022
New York Proton Center
2010-2019
University of Chicago
2013-2019
Johns Hopkins University
2005-2018
GTx (United States)
2018
Abstract Purpose: Increased prostate cancer risk has been reported for BRCA mutation carriers, but BRCA-associated clinicopathologic features have not clearly defined. Experimental Design: We determined prevalence in 832 Ashkenazi Jewish men diagnosed with localized between 1988 and 2007 454 controls compared clinical outcome measures among 26 carriers 806 noncarriers. Kruskal-Wallis tests were used to compare age of diagnosis Gleason score, logistic regression models determine associations...
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is an autosomal dominant disorder in which germline mutations of fumarate hydratase (FH) gene confer increased risk cutaneous uterine leiomyomas cancer. HLRCC-associated cancer highly aggressive frequently presents as a solitary mass. We reviewed the clinicopathologic features 9 patients with tumors presenting sporadic cases but who were later proven to have FH mutations. Histologically, all showed mixed architectural...
The summary presented herein covers recommendations on the early detection of prostate cancer and provides a framework to facilitate clinical decision-making in implementation screening, biopsy, follow-up. This is Part I two-part series that focuses screening. Please refer II for discussion initial repeat biopsies as well biopsy technique. systematic review utilized inform this guideline was conducted by an independent methodological consultant. based searches Ovid MEDLINE Embase Cochrane...
The summary presented herein covers recommendations on the early detection of prostate cancer and provides a framework to facilitate clinical decision-making in implementation screening, biopsy, follow-up. This is Part II two-part series focusing initial repeat biopsies, biopsy technique. Please refer I for discussion screening recommendations. systematic review utilized inform this guideline was conducted by an independent methodological consultant. based searches Ovid MEDLINE Embase...
Urachal carcinomas occur mostly in the bladder dome, comprising 22% to 35% of vesical adenocarcinomas, and are generally treated by partial cystectomy with en bloc resection median umbilical ligament umbilicus. Detailed pathologic studies clinical outcome correlation few.We reviewed histologic material data from 24 cases selected a database 67 dome-based tumors diagnosed at our institution 1984 2005. Follow-up information was available for all patients.The mean age diagnosis 52 years (range:...
A significant number of prostate cancers have been shown to recurrent chromosomal rearrangements resulting in the fusion androgen-regulated TMPRSS2 promoter a member ETS transcription factor family, most commonly ERG. This results ERG overexpression, which may direct causal role tumorigenesis or progression. However, clinical significance rearrangement is unclear, and particular, relationship outcome has inconsistent recent reports. We analyzed TMPRSS2-ERG gene status by fluorescence situ...
To retrospectively measure the mean apparent diffusion coefficient (ADC) with diffusion-weighted magnetic resonance (MR) imaging and metabolic ratio (MET) three-dimensional (3D) hydrogen 1 ((1)H) MR spectroscopic in regions of interest (ROIs) drawn over benign malignant peripheral zone (PZ) prostatic tissue to assess ADC, MET, combined ADC MET for identifying ROIs, whole-mount histopathologic examination as reference standard.The institutional review board approved this HIPAA-compliant...
To retrospectively determine the accuracy of diffusion-weighted (DW) magnetic resonance (MR) imaging for identifying cancer in prostate peripheral zone (PZ) and to assess tumor volume measurements made with T2-weighted combined DW MR by using surgical pathologic examination as reference standard.The institutional review board issued a waiver informed consent this HIPAA-compliant study. Forty-two patients underwent endorectal at 1.5 T before undergoing radical prostatectomy had least one PZ...
The differential diagnosis of renal cell neoplasms with solid or nested architecture and eosinophilic cytoplasm has become increasingly complex. Despite recent advances in classifying a number entities exhibiting this morphology, some tumors remain the unclassified category. Here we describe morphologically distinct group sporadic carcinoma (RCC) predominantly architecture, eosinophilic, remarkably vacuolated retrospectively identified from cohort previously tumors. We examined...
Defects in genes the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that overexpression of may also drive poorer outcomes cancer. The ribonucleotide reductase small subunit M2 (RRM2) is essential for synthesis and by producing dNTPs. It frequently overexpressed cancers, but very little known about its function
Digital pathology (DP) implementations vary in scale, based on aims of intended operation. Few laboratories have completed a full-scale DP implementation, which may be due to high overhead costs that disrupt the traditional workflow. Neither standardized criteria nor benchmark data yet been published showing practical return investment after implementing platform.To provide and metrics support operational efficiency cost savings large academic center.Metrics reviewed include archived asset...
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes operation in health care and education. In March 2020, institutions the United States began to implement a range policies discourage direct contact encourage social distancing. These measures have placed us an unprecedented position where education can no longer occur at close quarters—most notably, around multiheaded microscope—but must instead continue distance. This guide is intended...
Androgen receptor-signaling inhibitor (ARSi) drugs prolong life in metastatic castration-resistant prostate cancer (mCRPC), but such tumors eventually become resistant and progress. Comprehensive positron emission tomography/computed tomography (PET/CT) imaging using fluoro-2-D-deoxyglucose F 18 ([18F]-FDG) for glycolysis (Glyc) fluorodihydrotestosterone ([18F]-FDHT) androgen receptor (AR) expression determine heterogeneity of phenotypes, which may be useful distinguishing patients who will...
We report oncologic outcomes for men with Grade Group 1 prostate cancer managed active surveillance at a tertiary center.A total of 2,907 patients were between 2000 and 2017, whom 2,664 had disease. Patients recommended confirmatory biopsy to verify eligibility followed semiannually specific antigen, digital rectal examination review symptoms. Magnetic resonance imaging was increasingly used in recent years. Biopsy repeated every 2 3 years or after sustained antigen increase changes magnetic...