A5050978868- Thyroid Cancer Diagnosis and Treatment
- Social Media in Health Education
- Head and Neck Anomalies
- Radiology practices and education
- Glioma Diagnosis and Treatment
- Tumors and Oncological Cases
- AI in cancer detection
- Radio, Podcasts, and Digital Media
- Salivary Gland Tumors Diagnosis and Treatment
- Brain Metastases and Treatment
- BRCA gene mutations in cancer
- Health Literacy and Information Accessibility
- Innovations in Medical Education
- Lung Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Advances in Oncology and Radiotherapy
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Ear and Head Tumors
- Pancreatic function and diabetes
- Patient-Provider Communication in Healthcare
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Ecology and Conservation Studies
Duke Medical Center
2013-2024
Duke University Hospital
2015-2024
Duke University Health System
2014-2024
Duke University
2014-2024
Beth Israel Deaconess Medical Center
2023-2024
The University of Texas MD Anderson Cancer Center
2019-2024
Università Cattolica del Sacro Cuore
2019-2024
Massachusetts General Hospital
2019-2024
Faculty of Media
2019-2023
John Wiley & Sons (United States)
2019-2021
Purpose This phase II trial was designed to define the role of O 6 -benzylguanine (O -BG) in restoring temozolomide sensitivity patients with recurrent or progressive, temozolomide-resistant malignant glioma and evaluate safety administering -BG combination temozolomide. Patients Methods were accrued into two independent strata on basis histology: glioblastoma multiforme (GBM) anaplastic glioma. Both administered day 1 a 28-day treatment cycle. 1-hour infusion at dose 120 mg/m 2 followed...
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes operation in health care and education. In March 2020, institutions the United States began to implement a range policies discourage direct contact encourage social distancing. These measures have placed us an unprecedented position where education can no longer occur at close quarters—most notably, around multiheaded microscope—but must instead continue distance. This guide is intended...
Molecular testing provides an important ancillary study for thyroid nodules with indeterminate cytology. The nomenclature shift to "noninvasive follicular neoplasm papillary-like nuclear features" (NIFTP) will impact the performance of molecular tests. For current study, authors reviewed Afirma gene-expression classifier (GEC) and University Pittsburgh Medical Center (UPMC) targeted mutation panel tests in that were subsequently diagnosed as NIFTP on surgical resection.In total, 302 sent...
The vesicular monoamine transporter 2 (VMAT2) is localized primarily within the CNS and responsible for transporting monoamines from cytoplasm into secretory vesicles. Because reserpine (a VMAT inhibitor) can precipitate depressive-like symptoms in humans, we investigated whether Vmat2 heterozygous (HET) mice present with behaviors. mutants showed locomotor rearing retardation open field appeared anhedonic to 1 1.5% sucrose solutions. Immobility times heterozygotes were prolonged forced swim...
Abstract Purpose: This phase II trial was designed to define the efficacy of Gliadel wafers in combination with an infusion O6-benzylguanine (O6-BG) that suppresses tumor O6-alkylguanine-DNA alkyltransferase (AGT) levels patients recurrent glioblastoma multiforme for 5 days and evaluate safety this therapy. Experimental Design: a II, open-label, single center trial. On gross total resection tumor, up eight were implanted. Bolus O6-BG administered at 120 mg/m2 over 1 hour on 1, 3, 5, along...
The ThyroSeq mutational panel and Afirma gene expression classifier (GEC) are used to risk stratify cytologically indeterminate thyroid nodules. In the current study, authors evaluated performance of these tests within context ultrasonographic features with incorporation noninvasive follicular neoplasm papillary-like nuclear (NIFTP) nomenclature.The reviewed nodules using or GEC testing. For that were surgically resected, both studied ultrasound findings, comparing stratified by 2015...
Background In a previous worldwide survey, the authors showed drastic reduction in number of cytological specimens processed during coronavirus disease 2019 “lockdown” period along with an increase malignancy rates. To assess continued impact pandemic on practices around world, they undertook second follow‐up survey collecting data from post‐lockdown (2020). Methods Participants were asked to provide regarding their cytopathology activity first 12 weeks respective national (2020), which...
- Molecular testing in indeterminate thyroid nodules is a rapidly evolving field with variable reported outcomes.- To report our experience at tertiary referral center the Afirma Gene Expression Classifier (Veracyte, San Francisco, California) repeat fine-needle aspirations of previous cytologic result.- Results cytopathology and test were collected from August 2013 to March 2015, as diagnoses surgical resection when performed.- One hundred fifteen evaluated by Afirma. The aspiration...
This phase I clinical trial conducted with patients who had recurrent or progressive malignant glioma (MG) was designed to determine the maximum tolerated dose (MTD) and toxicity of three different 5-day dosing regimens temozolomide (TMZ) in combination O6-benzylguanine (O6-BG). Both TMZ O6-BG were administered on days 1–5 a 28-day treatment cycle. A bolus infusion at 120 mg/m2 over 1 h 1, 3, 5, along continuous 30 mg/m2/day. end first then every 24 for 5 during O6-BG. Patients accrued one...
// Gregory Michelotti 1 , Xiaoyin Jiang 2 Julie Ann Sosa 3 Anna Mae Diehl Brittany Bohinc Henderson 4 Division of Gastroenterology, Duke University Medical Center, Durham, North Carolina, USA Department Pathology, Surgery, Endocrinology, Diabetes and Metabolism, Wake Forest University, Winston-Salem, Correspondence to: Henderson, e-mail: bbhender@wakehealth.edu Keywords: R-spondin, Wnt, β-catenin, metastasis, BRAFV600E Received: May 07, 2015 Accepted: September 14, Published: 25, ABSTRACT...
The COVID-19 pandemic put most in-person pathology electives on-hold as departments adapted to changes in education and patient care. To address the subsequent void education, we created a free, virtual, modular, high-quality elective website. Website traffic from June 1, 2020, October was monitored using built-in analyses on Squarespace. Twitter engagement analyzed analytics Symplur Social Graph Score. A voluntary satisfaction survey sent all PathElective users results were analyzed. During...
Background The ThyroSeq panel tests for genetic alterations to risk‐stratify cytologically indeterminate nodules. authors assessed the test performance of tests, including latest version (v3), at an academic center. Methods Results from testing (v2 and v3) were reviewed over 2 years, patient demographics, cytology diagnoses, results testing, histopathologic diagnoses on resection (if available) collected. One hundred eighty‐five nodules tested 178 patients, 94 with v2 91 v3. Overall, 28 185...