A5050113969- AI in cancer detection
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Glutathione Transferases and Polymorphisms
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- Redox biology and oxidative stress
- Global Cancer Incidence and Screening
- Selenium in Biological Systems
- Ovarian cancer diagnosis and treatment
- Digital Imaging for Blood Diseases
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Infection Control and Ventilation
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
Linköping University Hospital
2018-2024
Linköping University
2019-2022
University College London
2009-2019
University College London Hospitals NHS Foundation Trust
2011-2019
Shadyside Hospital
2019
University of Pittsburgh
2019
Charing Cross Hospital
2017
The Christie NHS Foundation Trust
2017
The London College
2016
Royal London Hospital
2014
Spatial and temporal dissection of the genomic changes occurring during evolution human non-small cell lung cancer (NSCLC) may help elucidate basis for its dismal prognosis. We sequenced 25 spatially distinct regions from seven operable NSCLCs found evidence branched evolution, with driver mutations arising before after subclonal diversification. There was pronounced intratumor heterogeneity in copy number alterations, translocations, associated APOBEC cytidine deaminase activity. Despite...
Patients with isolated mediastinal lymphadenopathy (IML) are a common presentation to physicians, and mediastinoscopy is traditionally considered the "gold standard" investigation when pathological diagnosis required. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) established as an alternative in patients lung cancer.To determine efficacy health care costs of EBUS-TBNA initial IML.Prospective multicenter single-arm clinical trial 77 consecutive IML from 5...
Standard bronchoscopic techniques (transbronchial lung biopsy and endobronchial biopsy) provide a diagnosis in 70% of patients with pulmonary sarcoidosis. Previous data suggest that ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has high sensitivity The feasibility utility combining EBUS-TBNA standard is unknown. aim this study was to evaluate the feasibility, safety efficacy combined suspected sarcoidosis enlarged mediastinal or hilar lymphadenopathy.Forty consecutive lymph...
Aims: Lung cancer is one of the most common causes lethality worldwide. Despite recent progress, long‐term survival remains poor. The aim this study was to explore expression pattern thioredoxin superfamily proteins as potential new diagnostic and/or predictive markers. Methods and results: 1 (Trx1), reductase (TrxR1), isoforms TrxR1‐v.2,3,5, glutaredoxin (Grx1) 2 (Grx2) examined by immunohistochemistry on paraffin‐embedded sections from 42 cases non‐small cell lung patients. Additional...
Purpose Retrospective studies indicate that expression of excision repair cross complementing group 1 (ERCC1) protein is associated with platinum resistance and survival in non–small-cell lung cancer (NSCLC). We conducted the first randomized trial, to our knowledge, evaluate ERCC1 prospectively assess superiority nonplatinum therapy over doublet for ERCC1-positive NSCLC as well noninferiority ERCC1-negative NSCLC. Patients Methods This trial had a marker-by-treatment interaction phase III...
Previous studies in animals and humans have shown that selenium compounds can prevent cancer development. In this work we studied the tumor preventive effect of supplementation, administrated as selenite, initiation, promotion progression phases a synchronized rat model for chemically induced hepatocarcinogenesis, resistant hepatocyte model. Selenite supra-nutritional but subtoxic doses (1 5 p.p.m.) was to through drinking water. Such supplementation during initiation phase did not effect....
Background In a previous worldwide survey, the authors showed drastic reduction in number of cytological specimens processed during coronavirus disease 2019 “lockdown” period along with an increase malignancy rates. To assess continued impact pandemic on practices around world, they undertook second follow‐up survey collecting data from post‐lockdown (2020). Methods Participants were asked to provide regarding their cytopathology activity first 12 weeks respective national (2020), which...
<h3>Background</h3> Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have natural history development progressing through increasing severity dysplasia to in situ (CIS), and some cases, ending transformation invasive carcinoma. Synchronous lesions identified autopsy been previously shown be clonally related. <h3>Methods</h3> Using autofluorescence bronchoscopy that allows visual observation within upper...
Abstract Background The present study was carried out to investigate if methotrexate (MTX) has a direct lethal effect in renal tubular cells, and so, further clarify the mechanisms of cell death. Materials Methods Renal cells (LLC‐PK 1 cells) were incubated with MTX (0.01 µM, 0.1 µM), either alone or combination µM amiloride (Na + /H antiporter inhibitor) carbachol (M‐cholinergic agonist). Cell viability then determined by means trypan blue (TB) exclusion tests MTT assays. Results After 4 hr...
Abstract Two hundred and forty‐nine women suffering from breast problems underwent a complete series of tests including clinical examination, mammography, echography, thermography, fine‐needle aspiration (FNA). Ninety‐four these patients were shown to be positive or have suspected malignancy. Accordingly, they surgical excision followed by histologic while the remaining re‐examined after 12 18 mo in order exclude false negatives. The analysis specificity sensitivity every single procedure...
High-risk human papilloma virus (HR HPV) testing and liquid-based cytology are used for primary cervical screening. Digital cytology, based on whole-slide scanned samples, is a promising technique teaching diagnostic purposes. The aim of our study was to evaluate the interobserver intraobserver variation in low-grade squamous lesions, HR HPV status bias, use digital slides.Fifteen expert cytopathologists evaluated 71 digitalized ThinPrep slides (31 atypical cells undetermined significance...
Hepatocellular Carcinoma (HCC) is one of the most frequent cancers worldwide, however, prognosis remains poor following its discovery. We investigate Thioredoxin superfamily proteins as diagnostic markers for HCC. Furthermore, we delineate possible roles endoplasmic reticulum member superfamily, ERdj5, in carcinogenesis. Using antibodies against 1, Reductase 1 and performed immunohistochemistry on paraffin embedded liver biopsy sections from HCC patients. All three redox exhibited elevated...
Somatostatin receptor (SSTR) scintigraphy with (99m)Tc-depreotide is used for differential diagnosis of solitary pulmonary nodules. The method based on SSTR expression in cancer tissue.To estimate the SSTRs non-small-cell lung (NSCLC) vitro, and to determine correlation between uptake vivo different tumor characteristics determined such as grade, presence SSTR2, MIB-1, p53.A total 127 patients lesions detected computed tomography (CT) were investigated after injection 740 MBq...
Abstract Limited studies on whole slide imaging (WSI) in surgical neuropathology reported a perceived limitation the recognition of mitoses. This study analyzed and compared inter- intra-observer concordance for atypical meningioma, using glass slides WSI. Two neuropathologists two residents assessed histopathological features 35 meningiomas—originally diagnosed as atypical—in representative corresponding For each histological parameter final diagnosis, we calculated viewing modes predictive...
BackgroundPancreatic cancer is an aggressive malignancy and a leading cause of death worldwide; its lethality partly linked to the difficulty early diagnosis. Modern devices for endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) were recently developed improve targeting sampling small lesions, but innovative technologies microscopic assessment are still lacking. Ex vivo fluorescence confocal laser microscopy (FCM) new digital tool real-time fresh unfixed biological specimens, avoiding...
In order to assess whether morphometric parameters could be of value in distinguishing between tall cell variant and classical pattern thyroid papillary carcinoma, the fine needle aspiration cytology (FNAC) samples 14 cases were analysed using Arcimage 5 software on an Acorn computer. Histological examination specimens allowe classification nine them as remaining five variants. The nuclear diameter (NDD) standard deviation distribution (NDSDD), th area (NAD) (NASDD), nuclear/cytoplasmic...
To investigate the potential of optical coherence tomography (OCT) to distinguish between normal and pathologic thyroid tissue, 3D OCT images were acquired on ex vivo samples from adult subjects (n=22) diagnosed with a variety pathologies. The follicular structure was analyzed in terms count, size, density sphericity. Results showed that highly agreed corresponding histopatology calculated parameters representative variation. analysis volumes provides quantitative information could make...