A5008882033- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gestational Diabetes Research and Management
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Heart Rate Variability and Autonomic Control
- Metabolomics and Mass Spectrometry Studies
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
Deutsches Diabetes-Zentrum e.V.
2016-2025
University of Tübingen
2016-2025
German Center for Diabetes Research
2016-2025
Universität Ulm
1995-2025
Heinrich Heine University Düsseldorf
2016-2025
University Hospital Ulm
2022-2025
Hochschule Düsseldorf University of Applied Sciences
2024
University Children's Hospital Tübingen
2013-2023
Universitätsklinikum Tübingen
2009-2022
Institute of Diabetes Research
2013-2022
Abstract Obesity is a key risk factor for the development of insulin resistance, Type 2 diabetes and associated diseases; thus, it has become major public health concern. In this context, detailed understanding brain networks regulating food intake, including hormonal modulation, crucial. At present, little known about potential alterations cerebral ingestive behavior. We used “resting state” functional magnetic resonance imaging to investigate connectivity integrity resting state (RSNs)...
Abstract Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet fatty foods triggers liver accumulation disrupted brain action outlasted the time-frame of its consumption in healthy men. Hence, response can adapt changes diet before may facilitate development obesity associated diseases.
Abstract Background The pathogenesis of type 2 diabetes is characterized by insulin resistance and β‐cell dysfunction. Pancreatic fat load may add to the development aim was thoroughly quantify content pancreas sections (caput, corpus, cauda) compare impact pancreatic, intrahepatic, visceral on secretion in humans. Methods Fifty‐one subjects were subjected an oral glucose tolerance test (OGTT) with glucose, insulin, C‐peptide measurements [28 displayed normal tolerance, 23 impaired fasting...
Animal studies suggest that insulin action in the brain is involved regulation of peripheral sensitivity. Whether this holds true humans unknown. Using intranasal application to human brain, we studied impacts on whole-body sensitivity and mechanisms process. Insulin was assessed by hyperinsulinemic-euglycemic glucose clamp before after placebo randomized order lean obese men. After spray subjects, a higher infusion rate necessary maintain euglycemia compared with placebo. Accordingly,...
Impaired brain insulin action has been linked to obesity, type 2 diabetes, and neurodegenerative diseases. To date, the central nervous effects of in obese humans still remain ill defined, no study thus far evaluated specific areas affected by resistance.In 25 healthy lean 23 overweight/obese participants, we performed magnetic resonance imaging measure cerebral blood flow (CBF) before 15 30 min after application intranasal or placebo. Additionally, participants explicitly rated pictures...
Introduction In the human brain, there are at least as many astrocytes neurons. Astrocytes known to modulate neuronal function in several ways. Thus, they may also contribute cerebral insulin actions. Therefore, we examined whether primary insulin-responsive and their metabolic functions affected by hormone. Methods Commercially available Normal Human were grown recommended medium. Major players signaling pathway detected real-time RT-PCR Western blotting. Phosphorylation events...
Obesity-related structural brain alterations point to a consistent reduction in gray matter with increasing body mass index (BMI) but changes white have proven be more complex and less conclusive. Hence, recently diffusion tensor imaging (DTI) has been employed investigate microstructural structure. Altogether, these studies mostly shown loss of integrity obesity-related factors several regions. However, the variety factors, including inflammation dyslipidemia, resulted competing influences...
Structural brain imaging studies have shown that obesity is associated with widespread reductions in gray matter (GM) volume. Although the body mass index (BMI) an easily accessible anthropometric measure, substantial health problems are more related to specific fat compartments, like visceral adipose tissue (VAT). We investigated cortical thickness measures a group of 72 healthy subjects (BMI range 20-35 kg/m(2), age 19-50 years). Multiple regression analyses were performed using VAT and...
The hypothalamus is of enormous importance for multiple bodily functions such as energy homeostasis. Especially, rodent studies have greatly contributed to our understanding how specific hypothalamic subregions integrate peripheral and central signals into the brain control food intake. In humans, however, neural circuitry hypothalamus, with its different subregions, has not been delineated. Hence, aim this study was map network using resting-state functional connectivity (FC) analyses from...
Abstract Brain insulin action regulates eating behavior and energy fluxes throughout the body. However, numerous people are brain resistant. How responsiveness affects long-term weight body fat composition in humans is still unknown. Here we show that high sensitivity before lifestyle intervention associates with a more pronounced reduction total visceral during program. High also associated less regain of mass nine year follow-up. Cross-sectionally, strong hypothalamus fat, while...
Intranasal spray application facilitates insulin delivery to the human brain. Although brain modulates peripheral metabolism, mechanisms involved remain elusive. Twenty-one men underwent two hyperinsulinemic-euglycemic clamps with d-[6,6-2H2]glucose infusion measure endogenous glucose production and disappearance. On separate days, participants received intranasal or placebo. Insulin spillover into circulation after was mimicked by an intravenous bolus on placebo day. a different day,...
Objectives It is a matter of debate whether impaired insulin action originates from defect at the neural level or transport hormone into brain. In this study, we aimed to investigate effect aging on concentrations in periphery and central nervous system as well its impact insulin-dependent brain activity. Methods Insulin, glucose albumin were determined 160 paired human serum cerebrospinal fluid (CSF) samples. Additionally, was applied young aged mice by subcutaneous injection...
OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass its distribution. Obesity type 2 diabetes are often associated with resistance, resulting impaired brain-derived modulation of peripheral metabolism. So far, no pharmacological treatment for resistance has been established. Since sodium–glucose cotransporter (SGLT2) inhibitors lower glucose levels modulate energy metabolism, we hypothesized that SGLT2...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
BACKGROUNDInsulin resistance of the brain can unfavorably affect long-term weight maintenance and body fat distribution. Little is known if how insulin sensitivity be restored in humans. We aimed to evaluate effects an exercise intervention on this relates exercise-induced changes whole-body metabolism behavior.METHODSIn clinical trial, sedentary participants who were overweight obese underwent 8-week supervised aerobic training intervention. Brain was assessed 21 (14 women, 7 men; age range...
Abstract Insulin exerts its actions not only on peripheral organs but is also transported into the brain where it performs distinct functions in various regions. This review highlights recent advancements our understanding of insulin’s within brain, with a specific emphasis investigations humans. It summarises current knowledge transport insulin brain. Subsequently, showcases robust evidence demonstrating existence and physiological consequences action, while introducing presence resistance...