A5103013392- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Mobile Health and mHealth Applications
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Medication Adherence and Compliance
- Health Literacy and Information Accessibility
- Intracranial Aneurysms: Treatment and Complications
- Blood Pressure and Hypertension Studies
- S100 Proteins and Annexins
- Cerebrovascular and genetic disorders
- Neurological Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Lipoproteins and Cardiovascular Health
- Bone health and osteoporosis research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Vitamin C and Antioxidants Research
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Function and Risk Factors
- Genetic Associations and Epidemiology
Aga Khan University
2014-2025
Neurology, Inc
2021
Karachi Medical and Dental College
2019
Chandka Medical College
2019
Aga Khan University Hospital
2008-2017
Baylor College of Medicine
2016
Creative Research Enterprises (United States)
2016
Michael E. DeBakey VA Medical Center
2016
Health Services Research & Development
2016
National Institutes of Health
2015
The effectiveness of mobile technology to improve medication adherence via customized Short Messaging Service (SMS) reminders for stroke has not been tested in resource poor areas. We designed a randomized controlled trial test the SMS on improving survivors Pakistan. This was parallel group, assessor-blinded, randomized, controlled, superiority trial. Participants were centrally fixed block sizes. Adult participants multiple medications with access cell phone and at least 4 weeks from onset...
Background and Purpose— The natural history, causative factors, outcomes of patients with cerebral venous thrombosis from Asia Middle East have not been well described. This descriptive multicenter study describes the results for in South East. Methods— retrospective prospective data radiologically confirmed were collected 4 centers located Pakistan United Arab Emirates. demographic, clinical, radiological, outcome recorded analyzed. Primary was death or dependency (modified Rankin score...
The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than any other region globally, but there little direct evidence about its determinants. Pakistan Risk Myocardial Infarction Study (PROMIS) an epidemiological resource to enable reliable study genetic, lifestyle and determinants CHD Asia. By March 2009, PROMIS had recruited over 5,000 cases first-ever confirmed acute myocardial infarction (MI) matched controls aged 30–80 years. For each participant,...
Background We developed and tested the effectiveness of a tailored health information technology driven intervention: “Talking Prescriptions” (Talking Rx) to improve medication adherence in resource challenged environment. Methods conducted parallel, randomized, controlled, assessor-blinded trial at Aga Khan University (AKU), Karachi, Pakistan. Adults with diagnosis cerebrovascular accident (CVA) or coronary artery disease (CAD) diagnosed least one month before enrollment, on anti-platelets...
Abstract Purpose To evaluate the utility of MR diffusion tensor imaging in diagnosing primary lateral sclerosis (PLS). Materials and Methods Five patients who met clinical criteria for a diagnosis PLS, two with possible PLS less than three years duration eight normal volunteers were studied using imaging. Results All seven showed decreased anisotropy increased constant PLIC, complete separation from control group, including early course illness. Conclusion Quantitative appears to be useful...
Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently MI through genome-wide association studies were
Intracranial atherosclerotic disease (ICAD) is the most common proximate mechanism of ischemic stroke worldwide. Approximately half those affected are Asians. For diagnosis ICAD, intra-arterial angiography gold standard to identify extent stenosis. However, noninvasive techniques including transcranial ultrasound and MRA now emerging as reliable modalities exclude moderate severe (50%-99%) Little known about measures for primary prevention disease. In terms secondary due intracranial...
Abstract Background Stroke is a major cause of morbidity and mortality, especially in low middle income countries. Medical management the mainstay therapy to prevent recurrence stroke. Current estimates are that only 1 6 patients have perfect adherence medication schedules. Using SMS (Short Messaging Service) as reminders take medicines been used previously for diseases such diabetes HIV with moderate success. We aim explore effectiveness acceptability increasing medications Methods This...
The burden of neurological diseases in developing countries is rising although little known about the epidemiology and clinical pattern disorders. objective this study was to understand disease faced by neurologists a tertiary care setting.A prospective observational conducted all presentations neurology clinics at Aga Khan University Hospital Karachi over period 2 years. A total 16,371 out-patients with were seen during period. mean age participants 46.2 ± 18.3 years 8508 (52%) male....
Limited data exist on the frequency and outcome of carotid artery disease in Pakistan. Such information would help guide usefulness screening for condition this low-middle income health care setting.A prospective, descriptive study was conducted among 3 large teaching hospitals Karachi, Patients referred Doppler ultrasound examination were included if they had experienced a stroke or TIA within previous month. The severity morphology characterized by trained technicians using standardized...
Cerebral vein thrombosis has been well recognized for nearly two centuries. However, therapeutic options the condition are limited due to lack of large randomized trials. The various modalities reportedly used include antiplatelets, anticoagulation, fibrinolysis, and mechanical thrombectomy. Of these, antiplatelets least studied, there only anecdotal reports aspirin use. Anticoagulation is most widely accepted modality with favorable outcomes documented in controlled Various fibrinolytic...
Intracranial Atherosclerotic Disease (ICAD) is the most frequent etiology of stroke with high prevalence among Asians. Despite this, early determinants ICAD have not been described from this region.The study an analytical prospective cross-sectional 200 adults Radiology Departments two diagnostic centers in Karachi. Eligible participants confirmed absence symptoms via Questionnaire for Verifying Stroke Free Status (QVSFS) and underwent interview covering medical, socio demographic, lifestyle...
Non-communicable diseases (NCD) are the leading causes of death globally. In Pakistan, they among top ten mortality, especially in productive age group (30–69 years). Evidence suggests that health perceptions and beliefs strongly influence behavior an individual. We performed focus interviews to delineate same so as design user interface a non-invasive stroke risk monitoring device. It was qualitative study, designed explore how for NCD prevention. Four discussions (FGD) were conducted with...
Background There are no descriptions of stroke mechanisms from intracranial atherosclerotic disease in native South Asian Pakistanis. Methods Men and women aged ≥18 years with acute presenting to four tertiary care hospitals Karachi, Pakistan were screened using magnetic resonance angiography/transcranial Doppler scans. Trial ORG 10172 Acute Stroke Treatment criteria applied identify strokes disease. Results We studied 245 patients due Two hundred thirty scans reviewed. Also, 206/230 (89·0%)...