A5101607875- Acute Myeloid Leukemia Research
- Nerve injury and regeneration
- Constructed Wetlands for Wastewater Treatment
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Advanced Antenna and Metasurface Technologies
- Magneto-Optical Properties and Applications
- Bone and Joint Diseases
- Metamaterials and Metasurfaces Applications
- Hematological disorders and diagnostics
- RNA Research and Splicing
- Wastewater Treatment and Nitrogen Removal
- Urban Green Space and Health
- Coastal wetland ecosystem dynamics
- Photonic and Optical Devices
- Chronic Myeloid Leukemia Treatments
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Neuroscience and Neural Engineering
- Land Use and Ecosystem Services
- Robotic Path Planning Algorithms
- Urban Heat Island Mitigation
- Optical Coatings and Gratings
- Plasmonic and Surface Plasmon Research
- Immunotherapy and Immune Responses
Shanghai Ocean University
2022-2024
Shanghai Sixth People's Hospital
2013-2024
Shanghai Jiao Tong University
2013-2024
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
Zigong First People's Hospital
2024
Nanjing University of Aeronautics and Astronautics
2023-2024
Ministry of Industry and Information Technology
2024
Wenzhou Medical University
2024
China Medical University
2024
Peripheral nerve injury usually impairs neurological functions. The excessive oxidative stress and disrupted bioelectrical conduction gives rise to a hostile microenvironment impedes regeneration. Therefore, it is of urgent need develop tissue engineering products which help alleviate the insults restore signals. Melatonin (MLT) an important endogenous hormone that diminishes accumulation reactive oxygen species. Reduced graphene oxide (RGO) possesses excellent electrical conductivity...
Abstract Cervical cancer (CC) remains highest in the mortality of female reproductive system cancers, while cisplatin (CDDP) resistance is one main reasons for lethality. Preceding evidence has supported that karyopherins are associated with chemoresistance. In this study, we simultaneously compared CDDP-incomplete responders CDDP-complete CC patients and CDDP‐insensitive cell lines CDDP‐sensitive group. We finally identified DNA-PKcs (PRKDC) was related to CDDP sensitivity after overlapping...
Abstract Geometric phase enabled by spin‐orbit coupling has attracted enormous interest in optics over the past few decades. However, it is only applicable to circularly‐polarized light and encounters substantial challenges when applied wave fields lacking intrinsic spin degree of freedom. Here, a new paradigm presented for achieving geometric elucidating concept topological complementary pair (TCP), which arises from combination two compact elements possessing opposite charge. Twisting TCP...
We demonstrate a simple subwavelength all-dielectric photonic device with greatly enhanced transverse magneto-optical Kerr effect (TMOKE) in the transmission mode. The concept utilizes diffracted waves of periodic magnetic material bismuth-substituted iron garnet grating to excite guided mode planar waveguide, and adds buffer layer under grating. In study, it was found that increasing refractive index can reduce coupling between so full width at half maximum spectra be narrowed, value TMOKE...
Abstract Background Molybdenum disulfide (MoS 2 ) has excellent physical and chemical properties. Further, chiral MoS (CMS) exhibits chiroptical enantioselective effects, the properties of CMS have been studied for treatment neurodegenerative diseases. Intriguingly, left- right-handed materials different effects on promoting differentiation neural stem cells into neurons. However, effect enantioselectivity peripheral nerve regeneration remains unclear. Methods In this study, CMS@bacterial...
To evaluate the effects of electroconvulsive stimulation (ECS) on long-term potentiation (LTP) and synaptophysin (SYP) in hippocampus rats under chronic unpredictable mild stress (CUMS).Sixty Sprague-Dawley were randomly divided into three groups (n=20 for each group): control group (no intervention), CUMS (subjected to 28 days exposure followed by 7 mock ECS treatment), CUMS+ECS treatment). Depressive behavior was assessed a sucrose preference test an open-field test. The LTP levels rat...
<b><i>Background:</i></b> The efficacy and safety of tacrolimus (TAC) cyclophosphamide (CTX) were prospectively examined in steroid-dependent or steroid-resistant primary focal segmental glomerulosclerosis (FSGS). <b><i>Methods:</i></b> Patients with biopsy-proven FSGS enrolled randomly divided into two groups: CTX TAC. treated (0.5–0.75 g/m<sup>2</sup>·month, i.v.) received prednisone at 0.8 mg/kg·day, while patients TAC (0.1...
Rigosertib has demonstrated therapeutic activity for patients with high-risk myelodysplastic syndrome (MDS) in clinical trials. However, the role of rigosertib MDS not been thoroughly characterized. In this study, we found out that induced apoptosis, blocked cell cycle at G2/M phase and subsequently inhibited proliferation CD34+ cells from MDS, while it minimally affected normal cells. Further studies showed acted via activation P53 signaling pathway. Bioinformatics analysis based on gene...
Abstract Blue‐green spaces have certain ecological, economic, and social benefits for urban development. Many evaluation index systems been developed to evaluate the health status of ecosystems; however, blue green are separately evaluated without considering synergistic effect between water in ecosystem, thus affecting unified planning construction cities. Therefore, based on existing studies, development process blue‐green space system is divided into three stages: Supply service stage,...
Trophoblasts as the particular cells of placenta play an important role in implantation and formation maternal-fetal interface. RND3 (also known RhoE) is a unique member Rnd subfamily small GTP-binding proteins. However, its function cytotrophoblasts (CTBs) at interface poorly understood. In present study, we found that expression was significantly increased trophoblasts from villous tissues patients with recurrent miscarriage (RM). inhibited proliferation migration promoted apoptosis...
Summary In the myelodysplastic syndromes (MDS), haematopoietic cells show various levels of abnormal maturation and differentiation, which can be detected by flow cytometry. Testing anomalies stage‐ or lineage‐specific surface antigens in CD34 + blasts distinguish MDS from non‐clonal cytopenic diseases, also reflect pathological characteristics as a class clonal diseases for providing new clues to basic research. The present study established cytometric scoring system (FCMSS) based on...
Abstract Mutations in the U2 small nuclear RNA auxiliary factor 1 ( U2AF1 ) gene are common feature of a major subset myelodysplastic syndromes (MDS). However, genetic landscape and molecular pathogenesis oncogenic S34F mutation MDS not totally understood. We performed comprehensive analysis for prognostic significance mutations acute myeloid leukemia (AML) cohort based on The Cancer Genome Atlas (TCGA) database. Functional was vitro. Differentially expressed genes (DEGs) significantly...
Abstract The role of mesenchymal stromal cells (MSCs) in the pathogenesis myelodysplastic syndromes (MDS) has been increasingly addressed, but yet to be clearly elucidated. In this investigation, we found that MDS proliferated a greater extent on MDS-derived MSCs compared normal MSCs. Matrix metalloproteinase 1(MMP1), which was downregulated MDS-MSCs, identified as an inhibitory factor cell proliferation, given treatment with MMP1 inhibitor or knock-down resulted increased proliferation....