A5030191263- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- FOXO transcription factor regulation
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Nuclear Structure and Function
- Menopause: Health Impacts and Treatments
- Phytoestrogen effects and research
- Photodynamic Therapy Research Studies
- Cervical Cancer and HPV Research
- Cancer Mechanisms and Therapy
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Issues in Pregnancy
- Pelvic and Acetabular Injuries
Shanghai Sixth People's Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Shanghai Eighth People Hospital
2020-2021
Jiangsu University
2020-2021
Soochow University
2018
Health First
2012
Renji Hospital
2003
High-risk human papillomavirus oncoproteins E6 and E7 are the major etiological factors of cervical cancer but insufficient for malignant transformation cancer. Dysregulated alternative splicing, mainly ascribed to aberrant splicing factor levels activities, contributes most hallmarks. However, do regulate expression factors? Does acts as an "accomplice" E6E7 promote progression? Here, we identified that SRSF10, which promotes tumorigenesis cervix, was upregulated by via E2F1 transcriptional...
BackgroundEndometrial carcinoma (EC) is one of the most common gynecological malignancies among women. Maternal embryonic leucine Zipper Kinase (MELK) upregulated in a variety human tumors, where it contributes to malignant phenotype and correlates with poor prognosis. However, biological function MELK EC progression remains largely unknown.MethodsWe explored expression using TCGA GEO databases verified clinical samples by IHC methods. CCK-8 assay, colony formation cell cycle wound healing...
Abstract 3β-Hydroxysteroid-Δ24 reductase (DHCR24), the final enzyme of cholesterol biosynthetic pathway, has been associated with urogenital neoplasms. However, function DHCR24 in endometrial cancer (EC) remains largely elusive. Here, we analyzed expression profile and progesterone receptor (PGR) our tissue microarray EC (n = 258), existing database GEO (Gene Expression Omnibus), TCGA (The Cancer Genome Atlas). We found that was significantly elevated patients EC, up-regulation advanced...
Endometrial cancer (EC) is one of the most common female malignancies. The patients with high-risk factors may have poor prognosis. Therefore, there an urgent need to find a new molecule more accurately predict survival patients. Leucine-rich-alpha-2-glycoprotein1 (LRG1), leucine-rich repeat family, was closely associated metastasis and biological functions expression level LRG1 remain obscure in EC. In this study, by immunohistochemical analysis 242 EC patient tissues, we found that stage...
Abstract Cervical cancer (CC) remains highest in the mortality of female reproductive system cancers, while cisplatin (CDDP) resistance is one main reasons for lethality. Preceding evidence has supported that karyopherins are associated with chemoresistance. In this study, we simultaneously compared CDDP-incomplete responders CDDP-complete CC patients and CDDP‐insensitive cell lines CDDP‐sensitive group. We finally identified DNA-PKcs (PRKDC) was related to CDDP sensitivity after overlapping...
Abstract Dysfunction of nuclear factor- κ B (NF- B) signaling has been causally associated with numerous human malignancies. Although the NF- family genes implicated in endometrial carcinogenesis, information regarding involvement central regulators cancer (EC) is limited. Here, we investigated specific roles canonical and noncanonical tumorigenesis. We found that RelB protein, but not RelA, displayed high expression EC samples cell lines, predominant elevation endometrioid adenocarcinoma...
Abstract Aim: Endometrial carcinoma (EC) is a common gynecologic malignancy. EC has favorable prognosis because it usually diagnosed at an early stage. However, the recurrence rate high and poor for high‐risk EC. Identification of new biomarkers prediction features will help to guide treatment improve patients with Material Methods: Differentially expressed proteins among EC, low‐risk normal endometrial tissues were determined by two‐dimensional gel electrophoresis (2‐DE) liquid...
Epithelial ovarian cancer (EOC) is one of the leading causes cancer‑associated mortality in women. At present, overall 5‑year survival rate patients with EOC remains poor despite advancements diagnosis and treatment. Long non‑coding RNAs (lncRNAs) have attracted increasing attention recent years for their extensive roles tumorigenesis development. The lncRNA susceptibility candidate 2 (CASC2) was originally identified as a downregulated gene endometrial cancer, subsequent studies revealed...
Cervical cancer (CC) is a commonly diagnosed and primary consideration of patient death in female reproductive system malignancy. Cyclin-dependent kinase 12 (CDK12), as transcription-associated CDK, plays important roles tumor-promoting behaviors, whereas the underlying mechanisms CDK12 CC progression are still obscure. In this report, we investigated role cervical cancer. The current study identified mRNA protein expression remarkably upregulated patients. Upregulated was closely associated...
Far upstream element binding protein 1 (FUBP1), a DNA-binding protein, participates in diverse tumor-promoting behaviors by regulating the expression of oncogenes nucleus, but underlying mechanisms remain to be elucidated. In present study, we found that FUBP1 mRNA and expressions were markedly upregulated closely linked with poor prognosis cervical cancer. vitro, functional experiments showed knockdown inhibited CC cell proliferation migration. Therefore, plays prooncogenic function...
Background: Importin 7 (IPO7), a karyopherin-β protein, is involved in various tumorigenesis and progression abilities by mediating the nuclear import of oncoproteins. However, exact biological functions IPO7 remain to be further elucidated. Materials Methods: TCGA GEO datasets were used identify dysregulated expression cancers. Gain-of-function loss-of-function analyses oncogenic vitro vivo . Moreover, LC-MS/MS parallel reaction monitoring analysis comparatively profiled IPO7-related...
Ovarian cancer (OC) is a highly fatal gynecological malignancy worldwide, and cisplatin (CDDP) commonly used as an initial chemotherapy treatment for OC. Nonetheless, most patients ultimately face recurrence because of resistance to cisplatin. Therefore, it imperative investigate the underlying mechanisms drug in By analyzing differential gene expression using TCGA, GDSC, GEO public databases, we discovered that increased KLF4 strongly linked unfavorable outcomes Subsequent validation...
To determine if activation of the NF-kappaB-VCAM-1 pathway is mediated by protein kinase C-alpha (PKC-alpha).PKC inhibitor polymyxin B was added to cultured human umbilical vein endothelial cells (HUVECs) from normal pregnancies. Sera women with uncomplicated pregnancies and preeclampsia (PE) were control intervention groups HUVECs. Cytoplasmic membrane PKC, cytoplasmic NF-kappaB inhibitory factor (I-kappaB), NF-kappaBp65 measured. Cell viability, cell apoptosis, VCAM-1 expression...
The dysregulation of long noncoding RNAs (lncRNAs) has been reported to be correlated carcinogenesis and cancer progression. Endometrial (EC), arising from the endometrium or inner lining uterus, is one most common gynecological malignancies. We aim explore prognostic value lncRNAs in patients with endometrioid endometrial (EEC) identify potential lncRNA signature for predicting survival EEC.We performed a genome-wide analysis expression profiling Cancer Genome Atlas (TCGA)-Uterine Corpus...
The effects of adoptive transfer transforming growth factor (TGF)-β1-induced regulatory T (Treg) cells in preventing spontaneous abortion mice were investigated. CD4+CD25- isolated from the spleens pregnant CBA/J and induced into Treg positive for CD4, CD25 forkhead box P3 (FOXP3) ex vivo using interleukin (IL)-2 TGF-β1. mated with DBA/2J to establish a model and, on first day pregnancy, injected intravenously 2 × 105 either freshly or those After 14 days, surviving reabsorbed fetuses both...
The aim of the present study was to investigate characteristic microRNAs (miRNAs) expressed during pre‑invasive and invasive stages cervical cancer. A gene expression profile (GSE7803) containing 21 squamous cell carcinoma samples, 10 normal epithelium samples seven high‑grade intraepithelial lesion obtained from Gene Expression Omnibus. Differentially genes (DEGs) were identified using significance analysis microarray software, a Ontology (GO) enrichment conducted Database for Annotation,...