A5101760696- Alzheimer's disease research and treatments
- Acute Myeloid Leukemia Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Radiomics and Machine Learning in Medical Imaging
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Prion Diseases and Protein Misfolding
- Neurological Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticle-Based Drug Delivery
- Advanced Glycation End Products research
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Pharmacological Effects and Toxicity Studies
- Chronic Myeloid Leukemia Treatments
Shanghai Jiao Tong University
2015-2025
University of Rhode Island
2018-2025
Shanghai Ninth People's Hospital
2011-2025
Ningbo Medical Center Lihuili Hospital
2021-2025
Ningbo University
2021-2025
Stony Brook University
2009-2024
Deyang Stomatological Hospital
2024
Xi'an Jiaotong University
2024
Huazhong University of Science and Technology
2015-2024
Affiliated Hospital of Southwest Medical University
2024
Abstract Extracellular cytokines are enriched in the tumor microenvironment and regulate various important properties of cancers, including autophagy. However, precise molecular mechanisms underlying link between autophagy extracellular remain to be elucidated. In present study, we demonstrate that IL-6 activates through IL-6/JAK2/BECN1 pathway promotes chemotherapy resistance colorectal cancer (CRC). Mechanistically, triggers interaction JAK2 BECN1, where phosphorylates BECN1 at Y333. We...
BackgroundArtificial intelligence (AI) models in real-world implementation are scarce. Our study aimed to develop a CT angiography (CTA)-based AI model for intracranial aneurysm detection, assess how it helps clinicians improve diagnostic performance, and validate its application clinical implementation.MethodsWe developed deep-learning using 16 546 head neck CTA examination images from 14 517 patients at eight Chinese hospitals. Using an adapted, stepwise evaluation, 120 certified 15...
To explore the genetic abnormalities that cooperate with AML1-ETO ( AE ) fusion gene to cause acute myeloid leukemia (AML) t(8;21), we screened a number of candidate genes and identified 11 types mutations in C-KIT mC-KIT ), including 6 previously undescribed ones among 26 54 (48.1%) cases t(8;21). address possible chronological order between mC-KIT, showed that, patients , most leukemic cells at disease presentation harbored both alteration, whereas three such investigated during complete...
Cerebral microvascular amyloid beta protein (Abeta) deposition and associated neuroinflammation is increasingly recognized as an important component leading to cognitive impairment in Alzheimer's disease related cerebral angiopathy disorders. Transgenic mice expressing the vasculotropic Dutch/Iowa (E693Q/D694N) mutant human Abeta precursor brain (Tg-SwDI) accumulate abundant fibrillar deposits exhibit robust neuroinflammation. In present study, we investigated effect of anti-inflammatory...
Abstract Objective Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties exhibited therapeutic effects animal models of several degenerative disorders. However, effect trehalose on AD pathology remains largely unknown. Methods In this study, we evaluated APP/PS1 transgenic mice through...
The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid (CSF) influx from the perivascular spaces into interstitial space rapidly transport solutes and clear waste brain. However, presence of advection in neuropil is contested are claimed to be transported by diffusion only. To address this controversy, we implemented a regularized version optimal mass (rOMT) problem, wherein advection/diffusion equation only priori assumption required. rOMT analysis with...
We examined mRNA expression and internal tandem duplication of the Fms-like tyrosine kinase 3 (FLT3) gene in haematological malignancies by reverse transcriptase-polymerase chain reaction (RT-PCR) genomic PCR followed sequencing. By RT-PCR, FLT3 was detected 45/74 (61%) leukaemia cell lines frequency significantly higher undifferentiated type (B-precursor acute lymphoblastic leukaemia; ALL) than differentiated (B-ALL) (P = 0.0076). Using method, 194 fresh samples including 87 myeloid...
To identify the molecular signatures that predict responses to decitabine (DAC), we examined baseline gene mutations (28 target genes) in 109 myelodysplastic syndrome (MDS) patients at diagnosis. We determined TP53 predicted complete response (CR), as 10 of 15 (66·7%) who possessed achieved a CR. Univariate and multivariate analyses showed are only predictive CR DAC MDS. Among ten with CR, nine presented complex karyotypes due abnormalities involving chromosome 5 and/or 7, eight monosomies....
In a previous study in patients with intracranial hemorrhage (ICH), we found an association between high neutrophil-to-lymphocyte ratio (NLR) poor short-term mortality. the current study, this preliminary finding was validated using independent patient cohort. A total of 181 ICH (from January 2016 to December 2017) were included. Diagnosis confirmed computed tomography (CT) all cases. Patient survival (up 30 days) compared subjects NLR (above 7.35 cutoff; n = 74) versus low (≤ 7.35; 107)...
We determined the biological and prognostic significance of five recurrent genetic aberrations in Chinese patients with myelodysplastic syndromes (MDS). A total 304 MDS were screened for known mutations genes (ASXL1, U2AF1, SF3B1, SRSF2, EZH2) using next-generation sequencing. Of these, 97 (31.9 %) harbored at least one mutation genes, harboring these had distinct clinical features. Incidence ratios ASXL1, EZH2 11.8, 8.6, 8.2, 4.3, 3.6 %, respectively. Patients more commonly high-risk than...
Alzheimer's disease (AD) is an age-dependent neurodegenerative condition that causes a progressive decline in cognitive function. Accumulation of amyloid β-protein (Aβ) the brain prominent feature AD and related disorders. However, lev
Gastrointestinal stromal tumour (GIST) is the most common soft tissue sarcoma. The identification of molecular mechanisms regulating GIST progression vital for its treatment and prevention. Increasing reports have demonstrated that epigenetic alterations play critical roles in development. However, role histone demethylase KDM4D poorly understood.In clinically matched tissues, protein levels were measured by Western blot immunohistochemical (IHC) staining. mRNA examined quantitative...
Abstract Resveratrol (RES) has been studied extensively as an anticancer agent. However, the effects of triacetylresveratrol (TRES, acetylated analog RES) which higher bioavailability have not well established. We comparatively evaluated their on cell proliferation, apoptosis and molecular changes in STAT3, NFκB apoptotic signaling pathways pancreatic cancer cells. Apoptosis was determined by flow cytometry. The nuclear translocation interaction STAT3 were detected Western blotting...
Abstract Cerebral amyloid angiopathy (CAA) is a prevalent vascular dementia and common comorbidity of Alzheimer’s disease (AD). While it known that fibrillar β (Aβ) deposits leads to deterioration can drive parenchymal CAA related inflammation (CAA-ri), underlying mechanisms pathology remain poorly understood. Here, we conducted brain regional proteomic analysis early late stages in the rTg-DI rat model gain molecular insight CAA/CAA-ri progression identify potential protein markers...