A5023583015- Cardiac Imaging and Diagnostics
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
Huazhong Agricultural University
2022-2025
ISGylation is a well-established antiviral mechanism, but its specific function in immune and tissue homeostasis regulation remains elusive. Here, we reveal that the RNA-binding protein RBM47 undergoes phosphorylation-dependent at lysine 329 to regulate activation maintain lung homeostasis. K329R knockin (KI) mice with defective RBM47-ISGylation display heightened susceptibility LPS-induced acute injury tumorigenesis, accompanied multifaceted immunosuppression characterized by elevated...
Abstract Hypoxia modulates senescence, but their physiological link remains unclear. Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia. RNA-binding protein RBM38 eIF4E inhibit the GSK3β-mediated Ser195 disrupted RBM38-eIF4E interaction. Through investigation phosphorylation, eIF4E2-GSK3β pathway specifically regulated proline-directed serine/threonine (S/T-P)....