A5101643831- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Issues in Pregnancy
- Genomic variations and chromosomal abnormalities
- Urological Disorders and Treatments
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Photonic and Optical Devices
- Pediatric Urology and Nephrology Studies
- Birth, Development, and Health
- Trace Elements in Health
- Tracheal and airway disorders
- Gestational Diabetes Research and Management
- Esophageal and GI Pathology
- Advanced Fiber Laser Technologies
- Spinal Dysraphism and Malformations
- Heavy Metal Exposure and Toxicity
- Folate and B Vitamins Research
- Orbital Angular Momentum in Optics
- MRI in cancer diagnosis
- Cleft Lip and Palate Research
National University of Defense Technology
2021-2025
Hubei Provincial Women and Children's Hospital
2013-2023
Huazhong University of Science and Technology
2022
Wuhan Children's Hospital
2011-2017
Background Maternal smoking during pregnancy has been consistently associated with an increased risk of congenital heart defects (CHDs). However, few studies have reported the association between paternal and CHDs among offspring. This report presents first case‐control study to investigate possible periconceptional in China. Methods From February 2010 through October 2011, 284 case fetuses nonsyndromic 422 control no birth were recruited. The mothers cases controls interviewed regarding...
Abstract Background Birth defects are responsible for approximately 7% of neonatal deaths worldwide by World Health Organization in 2004. Many methods have been utilized examining the congenital anomalies fetuses. This study aims to investigate efficiency simultaneous CNV-seq and whole-exome sequencing (WES) diagnosis fetal anomaly based on a large Chinese cohort. Methods In this cohort study, 1800 pregnant women with singleton fetus Hubei Province were recruited from 2018 2020 prenatal...
Building on conventional dual-fiber optical trap systems, we have developed a multichannel chip that is simple and low-cost. This features three channels, enabling simultaneous capture of individual microspheres within liquid environment. With each microsphere being captured by opposing fibers at 45-mW power, the measured axial stiffnesses channel were 0.4626, 0.7184, 0.6467 pN/μm, respectively, whereas transverse 1.7794, 1.6885, 1.4560 pN/μm. may various applications in field microfluidics,...
<title>Abstract</title> The dual-fiber optical tweezers have become widespread in trapping, assembling, and sensing due to their simple fabrication process flexible operation. However, the miniaturization integration of displacement measurement paths remain challenging. Here, we propose experimentally demonstrate an structured-light (SLD) method tailored for tweezers. A key component split-waveplate is integrated onto fiber end via coating etching SLD method. etched another single mode form...
Objectives To evaluate the placental vascular architecture using MV Flow™ imaging for analyzing distribution per region of biological tissue in isolated congenital heart diseases (CHD), CHD associated with extracardiac malformations (EXM) and normal pregnancies, to explore relationship fetal Doppler flow parameters growth perfusion these conditions. Methods Placental microvascular structure was assessed MV‐Flow™ a total 227 fetuses 139 CHD; gestational age ranging from 11 41 weeks were...
Discovering the genotype-phenotype relationship is crucial for genetic engineering, which will facilitate advances in fields such as crop breeding, conservation biology, and personalized medicine. Current research usually focuses on single species small datasets due to limitations phenotypic data collection, especially traits that require visual assessments or physical measurements. Deciphering complex composite phenotypes, morphology, from at scale remains an open question. To break through...
Abstract The dual-fiber optical tweezers have become widespread in trapping, assembling, and sensing due to their simple fabrication process flexible operation. However, the miniaturization integration of displacement measurement paths remain challenging. Here, we propose experimentally demonstrate an structured-light (SLD) method tailored for tweezers. A key component split-waveplate is integrated onto fiber end via coating etching SLD method. etched another single mode form tweezers, which...
Abstract Background Congenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source indoor environmental pollution that detrimental to health. A growing body research suggests maternal occupational exposure renovation materials may be associated with an increased risk giving fetuses CHD. However, effect housing on CHD occurrence has not been reported. Methods multi-hospital case–control study was designed investigate association...
Abstract Structural anomalies of the central nervous system (CNS) are one most common fetal found during prenatal imaging. However, genomic architecture imaging phenotypes has not yet been systematically studied in a large cohort. Patients diagnosed with CNS were identified from medical records and images. Fetal samples subjected to low-pass deep whole-genome sequencing (WGS) for aneuploid, copy number variation (CNV), single-nucleotide variant (SNV, including insertions/deletions (indels)),...
Background Aluminum (Al) is the third most common element in earth' s crust and has been reported to be teratogenic. However, there lack of understanding about association between maternal aluminum exposure risks birth defects such as congenital heart (CHDs). Methods A multi‐center, hospital‐based case–control study was performed at four child tertiary hospitals China. total 223 cases with CHDs controls without any abnormalities were recruited according inclusion matching criteria. Hair...
Objectives To observe the microvascular architecture in placental bed and explore feasibility clinical utility of MV‐Flow imaging (Samsung Medison Co, Ltd, Seoul, Korea) during normal pregnancy fetal growth restriction (FGR). Methods Placental structure ultrasound by was performed on 227 unaffected 17 FGR fetuses between 11 41 weeks' gestation. A vascular index (VI MV ) acquired application various regions interest (ellipse, rectangle, manual trace). Unaffected control groups were assessed...
Background The aim of this study was to investigate the correlation between maternal concentrations copper and zinc risk having an infant with a congenital heart defect (CHD). Methods A multi‐center hospital‐based case‐control conducted in China. total 212 cases controls were recruited from pregnant women who received prenatal examinations four tertiary hospitals accredited perform diagnosis cities Shenzhen, Zhenzhou, Fuzhou Wuhan February 2010 November 2011. Correlation CHDs estimated by...
Abstract Background Many studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding relationship between cobalt and CHD in offspring. The aim this study was to analyze association mothers risk CHDs Materials methods In order explore defect (CHD), a case-control with 490 controls 399 cases China were developed. concentrations hair pregnant woman fetal placental tissue measured processed by logistic...
Congenital heart defects (CHDs) arise through various combinations of genetic and environmental factors. Our study explores how polymorphisms in the glutathione S-transferase (GST) genes affect association between cigarette smoke exposure CHDs. We analysed 299 mothers children with CHDs 284 without any abnormalities who were recruited from six hospitals. The hair nicotine concentration (HNC) was used to quantify maternal exposure, GSTT1, GSTM1 GSTP1 sequenced. found a trend higher adjusted...
Objective To examine the association between maternal diseases and congenital heart defects (CHDs) to evaluate whether those associations vary with corresponding medication use. Methods A multi-hospital case-control study conducted from February 2010 December 2014 analysed 916 controls 1236 cases. Participating mothers were asked they suffered influenza, common cold, herpes threatened abortion or had used during periconception period early pregnancy period. We a random-effects logistic...
This study was designed to investigate the feasibility of apparent diffusion coefficient (ADC) values in evaluating normal fetal brain development from gestational week 24 up term age.Diffusion-weighted imaging (DWI) performed on 40 fetuses (with results sonography and MRI results), with two b-values 0 600 s/mm² three (x, y, z) orthogonal axes. Ten regions interest (ROIs) were manually placed symmetrically bilateral frontal white matter (FWM), occipital (OWM), thalamus (THAL), basal ganglia...
Objective: This study aimed to construct new reference charts and equations for fetal biometry from Chinese fetuses at 15–40 weeks compare them with previous references.Method: was a prospective, cross-sectional of singleton pregnancies in patients confirmed gestational age who underwent ultrasound examinations between the 15th 40th gestation. Each woman selected only once this study. Biparietal diameter (BPD), head circumference (HC), abdominal (AC), femur length (FL) were recorded. For...
Objective: To evaluate the association between maternal influenza and congenital heart defects (CHDs), whether use of traditional Chinese medicine (TCM) or Western (antibiotics, antipyretic-analgesic drugs) modified this association.Method: We analysed 294 fetuses with CHDs 416 control without any abnormalities identified from February 2010 through October 2011 in hospital-based case-control study. Participating mothers were interviewed to determine they had been infected "influenza" during...
Abstract Background Congenital heart defects (CHDs) are the most common birth defect around world. Maternal prepregnancy obesity has been proposed as a risk factor of CHDs, but relationship CHD with over- and underweight is controversial, especially because body mass index (BMI) distribution differs between Asia West. The study aimed to examine potential associations maternal on offspring CHDs. Methods An ambispective observational involving 1206 fetuses CHDs 1112 without at seven hospitals...
Abstract Background Congenital heart defects (CHDs) are the most common birth defects. Assessment of incidence, distribution, disease spectrum, and genetic deficits fetal CHDs in China is urgently needed. Methods A national echocardiography screening program for was implemented 92 prenatal screening–diagnostic centers China. Findings total 18,171 CHD cases were identified from 2,452,249 pregnancies, resulting 7·4/1,000 as incidence rate CHD. The incidences six geographical regions, southern,...
Objectives The primary aim of this study was to establish the normal reference ranges fetal left ventricular (LV) Modified Myocardial Performance Index (Mod-MPI). A secondary evaluate agreement between manual and automatic measurements for Mod-MPI. Design prospective, multicentre, cross-sectional study. Participants Normal singleton pregnancies. Methods LV functions pregnancies were assessed in nine centres covering eight provinces China using unified ultrasound protocols settings...