A5103122191- Cardiac electrophysiology and arrhythmias
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Nanoplatforms for cancer theranostics
- Insect Resistance and Genetics
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Photochromic and Fluorescence Chemistry
- Cardiovascular Effects of Exercise
- Insect and Pesticide Research
- CRISPR and Genetic Engineering
- Innovative Microfluidic and Catalytic Techniques Innovation
- Quinazolinone synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Cardiac Fibrosis and Remodeling
- Corneal surgery and disorders
- Synthesis and Biological Evaluation
- Retinal Diseases and Treatments
- Receptor Mechanisms and Signaling
- Insect-Plant Interactions and Control
- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Synthesis of Indole Derivatives
- Fibroblast Growth Factor Research
Huazhong University of Science and Technology
2019-2025
First Affiliated Hospital of Zhengzhou University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Guangxi Center for Disease Prevention and Control
2024
University of Namur
2017-2024
Baise University
2024
Ministry of Education of the People's Republic of China
2017-2021
Zhejiang University
2017-2021
Bengbu Medical College
2021
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2014-2018
KCNMA1 encodes the large-conductance Ca2+- and voltage-activated K+ (BK) potassium channel α-subunit, pathogenic gain-of-function variants in this gene have been associated with a dominant form of generalized epilepsy paroxysmal dyskinesia. Here, we genetically functionally characterize eight novel loss-of-function (LoF) KCNMA1. Genome or exome sequencing participation international Matchmaker Exchange effort allowed for identification variants. Patch clamping was used to assess...
Drug leakage in blood circulation is generally a serious concern to polymersomes when loading water‐soluble chemotherapeutics. If packing density of polymersome membrane strengthened, premature drug release will be inhibited. Therefore, synthesis series amphiphilic polyphosphazenes (PNPs) with 2‐diethylaminoethyl 4‐aminobenzoate (DEAB) as hydrophobic side groups and amino‐terminal poly(ethylene glycol) (NH 2 ‐PEG 2000 ) hydrophilic chains presented. By controlling the ratio DEAB NH , optimal...
Climate warming is expected to increase the exposure of insects hot events (involving a few hours at extreme high temperatures). These are unlikely cause widespread mortality but may modify population dynamics via impacting life history traits such as adult fecundity and egg hatching. effects their potential impact on predictions still largely unknown. In this study, we simulated single event (maximum 38°C lasting for 4 h) magnitude increasingly found under field conditions examined its...
pH-responsive polymersomes have emerged as promising nanocarriers for antitumor drugs to realize their fast release and action in a weakly acidic microenvironment of tumor cells. Herein, however, we designed remarkably polymersome self-assembled from amphiphilic benzimidazole-based polyphosphazenes via the incorporation cholesteryl hemisuccinate (CholHS), type cholesteric molecule, into bilayers inhibit drug during blood circulation. Actually, unwanted premature leakage before arriving at...
Atrial fibrillation (AF) affects >30 million individuals worldwide. However, no genetic mutation from human patients with AF has been linked to inflammation. Here, we show that AF-associated variant p.Ile138Thr in natriuretic peptide A (NPPA) encoding the atrial (ANP) causes inflammation, fibroblast activation, fibrosis, and knock-in (KI) rats. Variant inhibits interaction between ANP its receptor reduces intracellular cGMP levels. RNA sequencing follow-up analyses showed mutant (mANP)...
Heat shock protein gene (Hsp) families are thought to be important in thermal adaptation, but their expression patterns under various stresses have still been poorly characterized outside of model systems. We therefore Hsp genes and stress responses the oriental fruit moth (OFM), Grapholita molesta, a widespread global orchard pest, compared this species that other insects. Genes from four showed variable levels among tissues developmental stages. Members Hsp40, 70, 90 were highly expressed...
Abstract Aim Loss‐of‐function KCNMA1 variants cause Liang–Wang syndrome (MIM #618729), a newly identified multiple malformation with broad spectrum of developmental and neurological phenotypes. However, the full clinical features underlying pathogenic mechanisms need elucidation. Methods Exome sequencing was used to identify variants. Patch‐clamp recordings were performed access effects on BK channels. Total membrane protein expression levels channels characterized using Western blotting....
Carbapenem resistant Klebsiella pneumoniae (CRKP) can cause serious hospital- and community-acquired infections. Treatment for CRKP infection is limited, resulting in prolonged hospitalization high consultation costs. The KPC genotype has the highest detection rate of CRKP, its mortality higher than overall CRKP. However, traditional testing methods have disadvantages such as long time reliance on complex sophisticated instruments, which are not conducive to rapid screening Therefore, this...
In this paper, we sequenced the complete mitogenome of English grain aphid, Sitobion avenae. The was mainly consisted 13 protein-coding genes, 22 tRNA 2 rRNA and large noncoding regions. 15,180-bp with a high A + T content (84.22%) arranged in same gene order as that ancestral insect. repeat region between trnE trnF included 1.29 copies 202 bp unit. Characterization S. avenae revealed architecture one important worldwide agricultural pests, thus advancing our understanding insect mitogenomic...
To study the possibility of generating photoreceptors through programming RPE transdifferentiation by examining cell differentiation after transplantation into developing chick eye.
Photoreceptors are highly specialized sensory neurons in the retina, and their degeneration results blindness. Replacement with developing photoreceptor cells promises to be an effective therapy, but it requires a supply of new photoreceptors, because neural retina human eyes lacks regeneration capability. We report efficient generation differentiating, photoreceptor-like from chick retinal pigment epithelial (RPE) propagated culture through reprogramming neurogenin1 (ngn1). In reprogrammed...
The bacterium
Idiopathic ventricular tachycardia (VT) occurs in structurally normal hearts and accounts for a significant number of all types VT. The genome-wide association study is the most effective strategy identifying novel genetic variants common diseases. However, no has been reported idiopathic VT.We conducted first VT Chinese Han population using discovery with 246 cases 648 controls replication 222 >4072 controls. Candidate genes were functionally characterized zebrafish. Real-time RT-PCR...
purpose. In examining the prospect of producing functional photoreceptors by reprogramming differentiation RPE progeny cells, this study was conducted to investigate whether reprogrammed cells can develop highly specialized ultrastructural and physiological traits that characterize retinal photoreceptors. methods. Cultured chick were differentiate along photoreceptor pathway ectopic expression neuroD. Cellular ultrastructure examined with electron microscopy. physiology studied monitoring...