A5100757227- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Regional Economic and Spatial Analysis
- Radiomics and Machine Learning in Medical Imaging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Genomics, phytochemicals, and oxidative stress
- Oral Health Pathology and Treatment
- Pharmacological Effects of Natural Compounds
- Medical Research and Treatments
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Culinary Culture and Tourism
- Lipid metabolism and biosynthesis
- Advanced MRI Techniques and Applications
- Animal Virus Infections Studies
- Organ Transplantation Techniques and Outcomes
Guangzhou University of Chinese Medicine
2017-2024
Zhongda Hospital Southeast University
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2019-2023
Shanghai Traditional Chinese Medicine Hospital
2018
The morbidity of nonalcoholic fatty liver disease (NAFLD) has been rising, but the pathogenesis NAFLD is still elusive. This study aimed at determining NAFLD-related hub genes based on weighted gene coexpression network analysis (WGCNA).GSE126848 dataset construction networks was performed WGCNA. Database for Annotation, Visualization, and Integrated Discovery (DAVID) utilized Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis. Hub were identified validated in independent...
Background: The combined effect of hepatitis B virus infection and metabolic dysfunction-associated steatotic liver disease (MASLD) on hepatocellular carcinoma (HCC) risk remains unclear. current study sought to elucidate the impact MASLD HCC progression in chronic (CHB) patients. Method: This retrospective cohort included CHB patients who had undergone biopsy abdominal imaging at Guangdong Provincial Hospital Chinese Medicine between 2013 2019. We investigated correlation risk, inverse...
Abstract Background and aims Numerous HBeAg-positive chronic hepatitis B (CHB) patients with persistently normal ALT have significant liver histopathology. It is imperative to identify true “immune tolerant” patients. We aimed evaluate the histopathology features of CHB incidence cirrhosis HCC in during follow-up. Methods 179 who performed biopsy from 2009 2018 were retrospectively analyzed. Liver necroinflammation ≥ G2 and/or fibrosis S2 was defined as histopathological change. Results...
The AnluoHuaxian pill (AHP) is a widely used patented medicine for chronic hepatitis B (CHB) patients with advanced fibrosis or cirrhosis that has been in China more than 15 years. However, data are lacking on whether monotherapy AHP can be effective CHB alanine aminotransferase (ALT) levels less 2 times the upper limit of normal (ALT<2ULN) and early liver (F ≤ 2). We aimed to investigate improves histology these patients. In this double-blind, randomized, placebo-controlled trial, 270...
Purpose: Both metabolic dysfunction-associated fatty liver disease (MAFLD) and hepatitis B virus (HBV) are risk factors for hepatocellular carcinoma (HCC). Although concurrent MAFLD is common in patients with HBV-related HCC, whether increases the of poor prognosis HCC remains unclear. This study aimed to investigate impact on HCC. Patients Methods: In this retrospective cohort study, 549 were enrolled from January 2010 April 2020 Guangdong Provincial Hospital Chinese Medicine, including 169...
Although human umbilical cord blood-derived mesenchymal stem cell transplantation (HUCB-MSCT) resulted in a good short-term therapeutic effect on patients with decompensated liver cirrhosis (DLC), the long-term survival remained unclear. This study aimed to evaluate impact of HUCB-MSCT outcomes DLC. retrospective cohort included hospitalized Liuzhou Hospital Traditional Chinese Medicine between November 2010 and February 2013. The primary outcome was overall (OS). secondary were 3-year...
BACKGROUNDHepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection, which may develop into liver fibrosis, cirrhosis and hepatocellular carcinoma.Detection early-stage fibrosis related to great clinical significance block progression lesion.Direct biopsy regarded as gold standard detect assess fibrosis; however, this method invasive prone sampling error.In order address these issues, we attempted find more convenient effective serum markers for detecting...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a novel proposed concept that being recognized worldwide. Both chronic hepatitis B (CHB) and MAFLD have been independently attributed to an increased risk of development cirrhosis. However, it still unclear whether associated with cirrhosis in CHB patients.This study aimed analyze the impact on patients.In this retrospective cohort study, consecutive patients or without were enrolled from January 1st, 2007, May 2020, Guangdong...
OBJECTIVES: Chronic hepatitis B (CHB) can progress into liver fibrosis and cirrhosis with poor outcomes. Early accurate diagnosis of fibrosis/cirrhosis is important to guide the preventive strategy their related complications. METHODS: A Chinese multicenter cross-sectional study was conducted develop validate a novel noninvasive program for staging in untreated patients CHB. Liver histology evaluated independently by 2 pathologists. The alanine aminotransferase ratio, Hepascore, aspartate...
Background and Aims: Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are at risk of disease progression. Currently, liver biopsy is suggested to identify this population. We aimed establish a non-invasive diagnostic model significant inflammation. Method: A total 504 CHB who had undergone ALT were randomized into training set ( n = 310) validation 194). Independent variables analyzed by stepwise logistic regression analysis. After the predictive for...
BackgroundThe aim of this study was to evaluate the accuracy LiveBoost™, a gradient boosting (GB)-based prediction system based on standard biochemical values (AST, ALT, platelet count) and age, in Chinese patients with chronic hepatitis B (CHB) compare its performance FIB-4 (fibrosis-4 score) APRI (the aspartate transaminase ratio index).MethodsThis retrospective trial enrolled 454 participants, including 279 CHB who underwent liver biopsy 175 normal controls from 3 centers China. All...
Currently, there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy. T2-weighted images (T2WI) routinely from magnetic resonance imaging (MRI) scan sequences. We aimed establish a radiomics signature based on T2WI (T2-RS) assessment in people with nonalcoholic fatty disease (NAFLD).A total 203 individuals biopsy-confirmed NAFLD two independent Chinese cohorts MRI were enrolled this study. The...
Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression CHB patients who refuse anti-viral treatment. However, data on histological changes after bicyclol treatment these are scarce. Therefore, this study has been conducted find out whether good benefits of improvement agents. The demographic, clinical and pathological were collected from received January 2010 June 2016. Improvement inflammation or fibrosis defined as at least...
This study aims to explore a useful noninvasive assessment containing TCM syndrome elements for liver fibrosis in CHB patients. The demographic, clinical, and pathological data were retrospectively collected from 709 patients who had ALT less than 2 times the upper limit of normal April 2009 October 2012. Logistical regression area under receiver-operator curve (AUROC) used determine diagnostic performances simple tests advanced (Scheuer stage, F ≥ 3). Results showed that most common element...
Prednisone plus azathioprine is considered the mainstay of therapy in current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits AIH patients because its serious side effects. Therefore, more and prefer to seek traditional Chinese medicine (TCM) manage their symptoms reduce effects steroids China. Shu-Gan-Jian-Pi Decoction a popular used herbal formula Guangdong province China, which has demonstrated effect improving efficacy reducing corticosteroids...
To demonstrate the potential to treat non-alcoholic fatty liver disease (NAFLD) with colon hydrotherapy (CHT) plus Traditional Chinese Medicine (TCM). A total of 20 patients were enrolled into study and received CHT TCM for 2 weeks. Body mass index (BMI) levels serum triglycerides (TG) cholesterol (TC) compared between pre-treatment post-treatment. Two-week treatment significantly lowered BMI reduced blood lipids. decreased from 29.5 ± 4.3 25.4 1.0, while mean TG by 0.70 mmol/L on average...
Abstract Objectives To explore the impact of hepatic steatosis measured by MRI-proton density fat fraction (MRI-PDFF) on liver stiffness measurement (LSM) value and its diagnostic performance for staging fibrosis in patients with chronic hepatitis B (CHB). Methods A total 914 CHB who underwent biopsy MRI-PDFF were retrospectively reviewed. The influence LSM was assessed using univariate multivariate linear analyses. assess LSM, a series ROC analyses performed compared stratifying into...
There is an unmet need for accurate non-invasive methods to diagnose non-alcoholic steatohepatitis (NASH). Since impedance-based measurements of body composition are simple, repeatable and have a strong association with fatty liver disease (NAFLD) severity, we aimed develop novel fully automatic machine learning algorithm, consisting deep neural network based on identify NASH [the bioeLectrical impEdance Analysis foR Nash (LEARN) algorithm].A total 1,259 consecutive subjects suspected NAFLD...
Abstract Background Nucleos(t)ide analogues (NAs) are the first-line option against chronic hepatitis B (CHB). NAs produce potent suppression of viral replication with a small chance HBsAg seroclearance and high risk virological relapse after discontinuation. The combined therapy plus traditional Chinese medicine (TCM) is widely accepted has been recognized as prospective alternative approach in China. Based on preliminary works, this study was designed to observe therapeutic effect TCM...
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Diagnosis of significant liver fibrosis is essential to facilitate the optimal treatment decisions and improve prognosis in patients with chronic hepatitis B (CHB). We aimed evaluate value inflammatory indicators construct a nomogram that effectively predicts among CHB patients. 563 from two centers China 2014 2019 were divided into three cohorts (development, internal validation, independent validation cohorts), assigned cases (liver stages ≥2) those without. Multiple biochemical...
Objective To evaluate the effect of Chai Shao Liu Jun Tang in combination with Lamivudine for treatment chronic hepatitis B (CHB) patients. Methods 405 CHB patients Guangdong Provincial Hospital were randomly divided into 2 groups, 220 treated group, and 185 control group. The group was 18 months. 18months. At 3rd, 6th, 9th, 12th 18th month during treatment, clinical symptoms, ALT normalization rate, HBeAg seroconversion proportion undetectable serum HBV DNA, YMDD mutation rate observed....