A5074876914- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Cancer Mechanisms and Therapy
- Traditional Chinese Medicine Studies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Gut microbiota and health
- Liver physiology and pathology
- interferon and immune responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Folate and B Vitamins Research
- IL-33, ST2, and ILC Pathways
- Pancreatitis Pathology and Treatment
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Aortic aneurysm repair treatments
- Organ Transplantation Techniques and Outcomes
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
2016-2024
Guangxi University
2008-2024
Guangxi University of Chinese Medicine
2009-2024
Ruikang Affiliated Hospital of Guangxi Medical University
2022
Hanzhong Central Hospital
2016
Affiliated Hospital of Jiangxi College of TCM
2008
To explore the regulation effect of Rheum palmatum (R. palmatum) L. on NF-κB signaling pathway ALF mice.The intraperitoneal injection d-GalN/LPS was employed for model building. Mice in treatment group and positive control were given R. bifendate before normal equivalent saline continuously 3 d. After 16 h building, blood collected from eyeballs mice then executed. The measurement performed content ALT, AST, NO Il-1β serum each group, as well activity Caspase 8 liver tissue. HE staining to...
Objective. To study the mechanism of curcumol affecting proliferation and apoptosis liver cancer cells through DJ-1/PTEN/PI3K/AKT pathway. Method. HepG2 were cultured in vitro, treated with at concentrations 10, 30, 100 μg/mL, DMSO was used as a control. The levels cell measured by CCK-8 flow cytometry, respectively. RT-PCR western blot to detect PTEN, p-AKT, DJ-1, PI3K gene protein expression changes. Result. (1) Compared blank control group, level 10 μg/mL group decreased, proportion...
Aim of the Study. To investigate preventative effects Jiedu Huayu (JDHY) on D-galactosamine (D-GalN) and lipopolysaccharide-induced acute liver failure (ALF) to evaluate possible mechanisms action. Materials Methods. ALF was induced in Wistar rats by administrating D-GalN (900 mg/kg) lipopolysaccharide (10 μg/kg). After treatment with JDHY granules, levels blood alanine aminotransferase, aspartate total bilirubin, prothrombin time were determined. Proliferating cell nuclear antigen detected...
"Jiedu Huayu" (JDHY) granules are traditional Chinese herbal compounds that have been used to treat severe liver injury for many years. The purpose of the current study is evaluate safety JDHY granules.Subchronic toxicity was tested in male and female rats were orally administered three different doses (80, 100, 130 g/kg/d) 13 weeks. Clinical signs, bodyweight, food consumption, hematological biochemical parameters, organ coefficients, histological changes observed during study.There no...
Mild micro-hepatic encephalopathy (MHE) is a severe complication of cirrhosis. At present, there are differences in the consistency detection strategies and treatment directions for MHE. The characteristic changes intestinal microbiota serum metabolites MHE patients possible relevant interaction mechanisms would inevitably affect developmental direction Therefore, characteristics were determined, interactions between them analyzed. Stool tests performed on both healthy individuals. 16S rRNA...
Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines with known therapeutic effect in treating acute liver failure (ALF). The aim this study was to investigate the amelioration efficacy JDHY lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF rat and explore possible molecular mechanism underlying efficacy.The determined by assessing hepatic pathology function LPS D-GalN challenged Wistar rat. We also evaluated on LPS-induced Kupffer cells measuring...
Jie-Du-Hua-Yu (JDHY) granules are a traditional Chinese medicine with known therapeutic effects for the treatment of acute liver failure (ALF). This study explored potential molecular mechanism(s) JDHY in promoting regeneration and preventing ALF.Rat models ALF were constructed through administration D-galactosamine (D-GalN) (600 mg/kg) lipopolysaccharides (LPS) (20 μg/kg). Rats gavaged granules, serum samples collected at 12 h post-D-GalN/LPS administration. The degree injury was evaluated...
Objective This study aims to explore the potential mechanisms of Jiedu Huayu granules (JDHY) mitigate D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced acute liver failure (ALF) in a cell damage model. Methods ALF was modeled using various concentrations D-GalN + LPS. JDHY-medicated serum at different then co-cultured with model proportion. The best concentration time intervention were determined by Cell Counting Kit-8, Alanine Aminotransferase (ALT), Aspartate (AST). Western...
DNA sensors play crucial roles in inflammation and have been indicated to be involved antitumor or tumorigenesis, while it is still unclear whether potential the prognosis immunotherapy of hepatocellular carcinoma (HCC). Herein, The Cancer Genome Atlas Gene Expression Omnibus databases were used analyze RNA sequencing data clinical information. A total 14 collected performed consensus clustering determine their molecular mechanisms HCC. Two distinct subtypes (Clusters C1 C2) identified...
It has been reported that plumbagin (PL) can inhibit tumor cell growth and induce apoptosis, but the underlying mechanisms remain unclear. In this study, nanoliposomes were prepared, Cell Counting Kit-8 (CCK-8) 5-ethynyl-2′-deoxyuridine (EdU) assays performed to determine effects of PL on HepG2 proliferation. Transwell wound healing also used investigate motility. Additionally, quantitative real-time polymerase chain reaction (qRT–PCR) was carried out confirm expression microRNAs (miRNAs)...
Abstract Background Nucleos(t)ide analogues (NAs) are the first-line option against chronic hepatitis B (CHB). NAs produce potent suppression of viral replication with a small chance HBsAg seroclearance and high risk virological relapse after discontinuation. The combined therapy plus traditional Chinese medicine (TCM) is widely accepted has been recognized as prospective alternative approach in China. Based on preliminary works, this study was designed to observe therapeutic effect TCM...
Objective:To investigate the expression and it's clinical significance of Survivin Bcl-2 in nasal squamous cell carcinoma (SNSCC). Method:The immunohistochemical Envision two step method was used to measure 35 cases SNSCC, 20 normal inferior concha tissues. Result:The SNSCC 88.6%, significantly higher than turbinate mucosal tissue 0% (P<0.01). The 71.4%, 25% Expression tissue. positively correlated with grade tumor, lower expressions Bcl-2. Conclusion:Survivin may play an promoting role...
To establish a high-quality, easy-to-use, and effective risk prediction model for hepatic encephalopathy, to help healthcare professionals with identifying people who are at high of getting guide them take early interventions reduce the occurrence encephalopathy. Patients (n = 1178) decompensated cirrhosis attended First Affiliated Hospital Guangxi University Chinese Medicine between January 2016 June 2022 were selected establishment validation nomogram In this study, we screened factors...
Abstract Background Recent studies have proved the association between gut microbiota (GM) through gut-brain axis and liver diseases, including hepatic fibrosis (HF) encephalopathy (HE). Nevertheless, specific microbial taxa identified in these shown variability. Furthermore, it's important to note that observational cannot definitively demonstrate causation.Our study aims explain potential causal relationship flora HF HE transcriptome Mendelian randomization analysis. Methods: A was...