A5100461453- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cervical Cancer and HPV Research
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Metabolomics and Mass Spectrometry Studies
- Macrophage Migration Inhibitory Factor
- Cancer-related molecular mechanisms research
- Neurological diseases and metabolism
- Cancer Cells and Metastasis
- Microbial Metabolism and Applications
- Cancer Mechanisms and Therapy
- Magnesium Alloys: Properties and Applications
- Tryptophan and brain disorders
- Peptidase Inhibition and Analysis
- Diabetes Management and Education
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
Liaoning Cancer Hospital & Institute
2021-2024
China Medical University
2021-2024
Guangxi University
2007-2023
Guangxi University of Chinese Medicine
2020-2023
Wenzhou Medical University
2022
Henan Agricultural University
2022
State Key Laboratory of Food Science and Technology
2022
Jiangxi Agricultural University
2022
Hebei Medical University
2020
Qiqihar Medical University
2016-2020
The relationship among the gut microbiome, global fecal metabolites and rheumatoid arthritis (RA) has not been systematically evaluated. In this study, we performed 16S rDNA sequencing liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based nontargeted metabolomic profiling on feces of 26 untreated RA patients healthy controls. Twenty-six genera forty-one MS2-identified were significantly altered in patients. Klebsiella, Escherichia, Eisenbergiella Flavobacterium more abundant...
Colorectal cancer (CRC) appears to be rather refractory checkpoint blockers except the patient with deficient in mismatch repair (dMMR). Therefore, new advances treatment of most proficiency (pMMR) (also known as microsatellite stability, MSS) type CRC patients are considered an important clinical issue associated programmed death 1 (PD-1) inhibitors. In present study, we evaluated effects gut microbiome MSS-type tumor-bearing mice treated different antibiotics on PD-1 antibody immunotherapy...
Neuroinflammation plays a critical role in Alzheimer's disease (AD). However, it is still unknown if neuroinflammation can be effectively treated using selenium nanoparticles (SeNPs) with different surface modifications. In this study, SeNPs were coated dihydromyricetin (DMY), natural polyphenol, to obtain DMY@SeNPs. Given that DMY@SeNPs are unstable under physiological conditions, they decorated step-by-step chitosan (CS/DMY@SeNPs) and the blood brain barrier (BBB) targeting peptide Tg...
Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC the 5th most commonly diagnosed cancer. The vast majority of cases are sporadic and evolve with adenoma-carcinoma sequence. There mounting evidence indicating that gut microbiota inflammation play important roles in development although study results not entirely consistent. current study, we investigated changes CRC-associated bacteria plasma inflammatory factors their relationships based on data from...
Certain antibiotics detected in urine are associated with childhood obesity. In the current experimental study, we investigated two representative urine, florfenicol and azithromycin, for their early effects on adipogenesis, gut microbiota, short-chain fatty acids (SCFAs), bile mice. Thirty C57BL/6 mice aged four weeks were randomly divided into three groups (florfenicol, azithromycin control). The administered or at 5 mg/kg/day weeks. Body weight was measured weekly. composition of body...
Gut microbiota is closely related to age. Studies from Europe and the U.S. identified featured in different age groups for elderly. Asian studies mainly focused on people living longevity areas. Featured elderly of groups, especially centenarian general population, has not been well investigated China.We conducted a comparative study by including 198 subjects three (65-70, 90-99, 100+ years) East China. Information regarding age, sex, height, weight, waist circumference, hip food preference,...
Introduction A growing body of evidence indicates that the dysbiosis both mammary and intestinal microbiota is associated with initiation progression breast tumors. However, microbial characteristics patients tumors vary widely across studies, replicable biomarkers for early-stage tumor diagnosis remain elusive. Methods We demonstrate a machine learning-based method analysis tissue gut differences among benign disease, cancer (BC), healthy individuals using 16S rRNA sequence data retrieved...
To explore the regulation effect of Rheum palmatum (R. palmatum) L. on NF-κB signaling pathway ALF mice.The intraperitoneal injection d-GalN/LPS was employed for model building. Mice in treatment group and positive control were given R. bifendate before normal equivalent saline continuously 3 d. After 16 h building, blood collected from eyeballs mice then executed. The measurement performed content ALT, AST, NO Il-1β serum each group, as well activity Caspase 8 liver tissue. HE staining to...
Polyphenols from peanut skin have been reported to possess many beneficial functions for human health, including anti-oxidative, antibacterial, anticancer, and other activities. To date, however, its anti-inflammatory effect the underlying mechanism remain unclear. In this study, of procyanidins extract (PSPE) (PSPc) were investigated by a dextran sodium sulfate (DSS)-induced colitis mouse model. The results showed that both PSPE PSPc supplementation reversed DSS-induced body weight loss...
Glucocorticoid‑induced osteoporosis is the commonest form of drug‑induced osteoporosis. Histone deacetylase 6 (HDAC6) involved in differentiation from mesenchymal stem cells to osteoblasts. However, role ricolinostat (ACY‑1215, HDAC6 inhibitor) dexamethasone (Dex)‑induced proliferation and preosteoblasts remains be elucidated. The protein expression mRNA levels HDAC6, osteopontin (OPN), runt‑related transcription factor 2 (Runx2), osterix (Osx), collagen I (COL1A1) glucocorticoid receptor...
Jie-Du-Hua-Yu (JDHY) granules are a traditional Chinese medicine with known therapeutic effects for the treatment of acute liver failure (ALF). This study explored potential molecular mechanism(s) JDHY in promoting regeneration and preventing ALF.Rat models ALF were constructed through administration D-galactosamine (D-GalN) (600 mg/kg) lipopolysaccharides (LPS) (20 μg/kg). Rats gavaged granules, serum samples collected at 12 h post-D-GalN/LPS administration. The degree injury was evaluated...
Regulatory T cells (Tregs) can exert immunosuppressive activity. Furin regulate Treg functions, hepatitis B virus (HBV) persistent infection, and hepatocellular carcinoma (HCC) development. However, it remains unknown whether furin the immune responses of Tregs to HBV HCC cells. Here, coculture systems HBV1.3P-HepG2.3P-HepG2 transduced with or without lentiviral particles that could overexpress knockdown furin/transforming growth factor β1 (TGFβ1) were established investigate regulatory...
Abstract To investigate the vaginal microbiota signature of patients with gynecologic cancer and evaluate its diagnostic biomarker potential. We incorporated 16S rRNA-seq data from 529 women utilized VSEARCH to analyze raw data. α-Diversity was evaluated utilizing Chao1, Shannon, Simpson indices, β-diversity through principal component analysis using Bray-Curtis distances. Linear discriminant effect size (LEfSe) determine species differences between groups. A bacterial co-abundance network...
It has been reported that plumbagin (PL) can inhibit tumor cell growth and induce apoptosis, but the underlying mechanisms remain unclear. In this study, nanoliposomes were prepared, Cell Counting Kit-8 (CCK-8) 5-ethynyl-2′-deoxyuridine (EdU) assays performed to determine effects of PL on HepG2 proliferation. Transwell wound healing also used investigate motility. Additionally, quantitative real-time polymerase chain reaction (qRT–PCR) was carried out confirm expression microRNAs (miRNAs)...
In this investigation, candidate traditional Chinese medicinal herbs for 3 neurodegenerative disorders, late-onset Alzheimer’s disease, Parkinson’s disease and Huntington were evaluated. The susceptibility genes integrated to reconstruct medicine-modern medicine network discover the herbs. For number of diseaserelated increased from 2 16, which are directly associated with ingredients. Many disorders identified (false discovery rate Benjamini-Hochberg<0.05). Four related β-amyloid 1-42...
Objective: To investigate the influence level of activity daily living about patients Alzheimer's disease.Methods: Stratified multistage cluster sampling method to determine survey, investigation and clinical diagnosis using two-stage screening method, stage mini mental-mental state examination (MMSE) activities (ADL), test.According diagnostic phase history, examination, neuropsychological testing assess, DSM-Ⅳ NINCDS-ADRDA criteria.On AD normal elderly controls were assessed scale...