A5103261144- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Traditional Chinese Medicine Analysis
- Cardiovascular Health and Disease Prevention
- Ion channel regulation and function
- Traditional Chinese Medicine Studies
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Sirtuins and Resveratrol in Medicine
- Cellular transport and secretion
- Flavonoids in Medical Research
- Coronary Interventions and Diagnostics
- Alzheimer's disease research and treatments
- Traditional and Medicinal Uses of Annonaceae
- Cardiovascular Function and Risk Factors
- Nerve injury and regeneration
- Chromatography in Natural Products
- Neurological diseases and metabolism
Beijing University of Chinese Medicine
2017-2024
Shanghai Jiao Tong University
2017-2024
Shanghai First People's Hospital
2022-2024
Shanghai Institutes for Biological Sciences
2012-2016
Chinese Academy of Sciences
2012-2016
Jilin Agricultural University
2016
State Key Laboratory of Neuroscience
2012
Hebei Medical University
2010-2011
Excitotoxicity induced by NMDA receptor-mediated intracellular Ca(2+) ([Ca(2+) ](i)) overload is a major cause of delayed neuronal death in cerebral ischemia. Transient receptor potential canonical (TRPC) 6 protects neurons from ischemic brain damage. However, the mechanisms which TRPC6 are largely unknown. Here, we reported that suppressed [Ca(2+)](i) elevation and protected excitotoxicity. Over-expressing or down-regulating aggravated under excitotoxicity, respectively. cultured damage...
Neurotrophin-3 (NT-3) plays numerous important roles in the CNS and elevation of intracellular Ca(2+) ([Ca(2+)](i)) is critical for these functions NT-3. However, mechanism by which NT-3 induces [Ca(2+)](i) remains largely unknown. Here, we found that transient receptor potential canonical (TRPC) 5 protein TrkC, receptor, exhibited a similar temporal expression rat hippocampus cellular colocalization hippocampal neurons. Stimulation neurons induced nonselective cation conductance...
As the greatest medical and socioeconomic problem in developing countries, stroke is second or third leading cause of death China worldwide. In adult organisms suffering from stroke, transplanted stem cells have ability to repair damaged tissues by regenerating autologous cells, while ginsenoside Rg1 could promote proliferation differentiation cells. Although obvious antistroke effects been verified publications, mechanism exploration remains challenging. Our study was carried out...
The voltage-gated M-type potassium channel, encoded mainly by the KCNQ2/3 genes, plays an important role in control of neuronal excitability. Mutations KCNQ2 gene lead to a form neonatal epilepsy humans termed 'benign familial convulsions', which is characterized hyperexcitability neurons. KCNQ openers or activators are expected decrease firing overactive neurons and thus conducive treatment pain. Here, we report that four novel synthesized derivatives pyrazolo[1,5-a]pyrimidin-7(4H)-one...
The use of arctigenin (ARG), a traditional medicine with many pharmacological activities, has been restricted due to its poor solubility in water. Five amino acid derivatives ARG have synthesized using glycine, o-alanine, valine, leucine, and isoleucine, which t-butyloxy carbonyl (BOC) as protective group. In this study, we examined the effects removing these groups. results showed that better nitrite-clearing ability than ARG. Among compounds tested, without group were best. Based on...
Chronic heart failure (CHF) is a major public health problem in huge population worldwide. The detailed understanding of CHF mechanism still limited. Zheng (syndrome) the criterion diagnosis and therapeutic Traditional Chinese Medicine (TCM). Syndrome prediction may be better approach for basis its treatment. authors studied disturbed metabolic biomarkers to construct predicting mode assess diagnostic value different syndrome explore herbal medicine (CHM) efficacy on patients. A cohort 110...
Objective Intraplaque neovascularization (IPN) is a known indicator of plaque vulnerability, and thus considered predictor stroke. The morphology location the carotid may be correlated with vulnerability. Therefore, our study aimed to examine associations IPN. Methods A total 141 patients atherosclerosis (mean age, 64.99 ± 10.96 years) who underwent contrast-enhanced ultrasound (CEUS) between November 2021 March 2022 were retrospectively analyzed. IPN was graded according presence...
Abstract Objective To explore the role of quantitative evaluation using carotid ultrasonography (US)-based high-frame-rate vector flow (V Flow) imaging in patients with low stenosis. Methods This single-centre cross-sectional study consecutively recruited volunteers without plaque and stenosis from August 2022 to May 2023. Patients were divided into symptomatic asymptomatic groups according their head CT or MRI results within 8 weeks. All V Flow examinations performed a Mindray Resona R9 US...
In a previous study, we showed that membrane depolarization induced elevation of phosphatidylinositol 4,5-bisphosphates (PtdIns(4,5)P2, also known as PIP2) and subsequently increased the KCNQ2/Q3 currents expressed in Xenopus oocytes through PI4 kinase activity. this underlying mechanism for depolarization-induced enhancement PIP2 synthesis was further investigated. Our results indicate activation protein C (PKC) isozyme βII responsible enhanced synthesis. We found phorbol-12-myristate,...
Adverse skin reactions are the most common side effects of epidermal growth factor receptor inhibitors (EGFRIs) in treatment cancer, significantly affecting survival rate and quality life patients. Qi Yin San Liang Decoction (QYSLS) comes from folk prescription is currently used clinical adverse caused by EGFRIs. However, its therapeutic mechanism remains unclear.To explore potential QYSLS EGFR inhibition using network pharmacology experimental research.First, we verified effectiveness vivo...