A5101410240- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Tryptophan and brain disorders
- interferon and immune responses
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- IL-33, ST2, and ILC Pathways
- Eicosanoids and Hypertension Pharmacology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Plant-based Medicinal Research
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Seaweed-derived Bioactive Compounds
- Mangiferin and Mango Extracts
- Restless Legs Syndrome Research
- Neurogenesis and neuroplasticity mechanisms
- Fibroblast Growth Factor Research
- Medicinal Plants and Bioactive Compounds
University of South China
2022-2025
Minzu University of China
2020-2023
Chinese Institute for Brain Research
2017-2022
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2017-2022
Jiangxi University of Traditional Chinese Medicine
2021-2022
State Ethnic Affairs Commission
2022
Center for Translational Molecular Medicine
2021
Chinese Academy of Sciences
2015-2017
Institute of Biophysics
2015-2017
Harbin Veterinary Research Institute
2012
Rationale: It is known that neuroinflammation plays a critical and detrimental role in the development of cerebral ischemia/reperfusion (I/R), but regulation cyclic GMP-AMP synthase (cGAS)-mediated innate immune response I/R-induced largely unexplored. This study aimed to investigate function regulatory mechanism cGAS brain injury, identify possible strategies for treatment ischemic stroke. Methods: To demonstrate microglial histone deacetylase 3 (HDAC3) regulates cGAS-stimulator interferon...
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but role autophagy in microglial activation during PD remains largely unclear. In this study, we showed that deletion
Abstract Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- stress-related disorders such as posttraumatic stress disorder (PTSD) anxiety disorder. Despite the abundant discoveries of neuroinflammation in disorders, underlying mechanisms still remain unclear. Method Wild-type Nlrp3 −/− mice were exposed to electric foot shocks contextual fear memory paradigm. Three hours after shocks, activation NLRP3 inflammasome was investigated...
The mitochondrion is susceptible to neurodegenerative disorders such as Parkinson's disease (PD). Mitochondrial dysfunction has been considered play an important role in the dopaminergic degeneration PD. However, there are no effective drugs protect mitochondria from during development. In present study, fucoidan, a sulfated polysaccharide derived Laminaria japonica, was investigated and characterized for its protective effect on dopamine system mitochondrial function of neurons...
Abstract Background Alteration of immune status in the central nervous system (CNS) has been implicated development post-traumatic stress disorder (PTSD). However, nature overall changes brain immunocyte landscape PTSD condition remains unclear. Methods We constructed a mouse model by electric foot-shocks followed contextual reminders and verified PTSD-related symptoms behavior test (including freezing test, open-field elevated plus maze test). examined panorama brains naïve or mice using...
Calhm2 has an important role in microglial activation and contributes to Alzheimer’s disease pathology.
Mitochondrial calcium uniporter (MCU) is a conserved Ca(2+) transporter at mitochondrial in eukaryotic cells. However, the role of MCU protein oxidative stress-induced cell death remains unclear. Here, we showed that ectopically expressed localized both HeLa and primary cerebellar granule neurons (CGNs). Knockdown endogenous decreases uptake following histamine stimulation attenuates induced by stress cells CGNs. We also found interacts with VDAC1 mediates overexpression-induced This finding...
Significance Adipocytes are the most abundant and perhaps active components of tumor microenvironment in obese individuals that potentiate breast tumorigenesis through secretory mechanisms. The modulation adipocytes can be novel therapy targets for cancer. Here, we revealed a specific upregulation adipocytic TAZ FFA/PPARγ axis diet-induced adiposity. Adipocytic knockdown or deficiency mice inhibits adipocyte-induced cancer proliferation stemness impaired expression secretion Resistin....
Neuroinflammation plays a critical role in ischemia-induced brain injury. Mib2, an E3 ubiquitin ligase, has been reported to regulate Notch signaling and participate the peripheral immune system. However, roles of Mib2 nervous system are not well characterized. In this study, we show that is involved lipopolysaccharide (LPS)- oxygen-glucose deprivation (OGD)-induced microglial activation. Mechanistically, interacts with IKK complex regulates activation NF-κB signaling, thus modulating Notch1...
Abstract Type I interferon (IFN-I) is critical for a host against viral and bacterial infections via induction of hundreds interferon-stimulated genes (ISGs), but the mechanism underlying regulation IFN-I remains largely unknown. In this study, we first demonstrate that ISG expression required optimal IFN-β levels, an effect further enhanced by endoplasmic reticulum (ER) stress. Furthermore, identify mitochondrial calcium uniporter protein (MCU) as antiviral signaling (MAVS)-interacting...
Activation of the NLRP3 inflammasome results in caspase 1 cleavage, which subsequently leads to IL-1β and IL-18 secretion, as well pyroptosis, aberrant activation is involved several diseases such type 2 diabetes, atherosclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease. activity regulated by various kinases. Genetic pharmacological inhibition hematopoietic cell kinase (HCK), a member Src family non-receptor tyrosine kinases (NRTKs) primarily expressed myeloid cells, has...
Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization the function of K+ channels, which are reported regulate activation microglia. However, little known about role Dlg1 in microglia maintenance central nervous system homeostasis. In this study, we found that knockdown suppressed lipopolysaccharide (LPS)-induced...
The pro-inflammatory activation of microglia is a hallmark Alzheimer’s disease (AD), and this process known to involve switch in energy metabolism from oxidative phosphorylation (OXPHOS) towards glycolysis. Here, we show how positive feedback loop microglia—comprising metabolic, histone lactylation, transcriptional layers—drives AD pathogenesis, demonstrate that inhibiting vicious cycle can ameliorate Aβ burden cognitive deficits model mice. After first detecting elevated lactylation both...
Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 a second-generation inhibitor XPO1, demonstrating lowest level side effects, currently in clinical trials for treatment cancers. Previous studies suggest several first-generation inhibitors XPO1 demonstrate anti-inflammation activities, indicating application this drug inflammation-related diseases. In study, our results suggested potent anti-inflammatory effect vitro...
Postpartum depression (PPD), a severe mental health disorder, is closely associated with decreased gonadal hormone levels during the postpartum period. Mangiferin (MGF) possesses wide range of pharmacological activities, including anti-inflammation. Growing evidence has suggested that neuroinflammation involved in development depression. However, role MGF PPD largely unknown. In present study, by establishing hormone-simulated pregnancy mouse model, we found administration significantly...