A5101773544- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Neural dynamics and brain function
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Axon Guidance and Neuronal Signaling
- Regulation of Appetite and Obesity
- Single-cell and spatial transcriptomics
- Developmental Biology and Gene Regulation
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
Wannan Medical College
2018-2024
First Affiliated Hospital of Wannan Medical College
2020-2024
Third Affiliated Hospital of Zhengzhou University
2024
Chinese Institute for Brain Research
2018-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2018-2023
National Institutes of Health
2020-2021
National Institute of Mental Health
2020-2021
Second Affiliated Hospital of Nanjing Medical University
2015-2019
Zhongshan Hospital
2009
Fudan University
2009
While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, biological significance of m6A mammalian glial development remains unknown. Here, we identify a novel reader, Prrc2a (Proline rich coiled-coil 2 A), which controls oligodendrocyte specification myelination. Nestin-Cre-mediated knockout induces significant hypomyelination, decreased lifespan, as well locomotive cognitive defects mouse model....
Saltified rutin enhances microglial Aβ clearance, providing a potential therapeutic avenue for Alzheimer’s disease treatment.
Calhm2 has an important role in microglial activation and contributes to Alzheimer’s disease pathology.
The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remain unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes in mouse brain. Additionally, multiplex fluorescent situ hybridization top marker genes...
Central amygdala neurons expressing protein kinase C-delta (CeA-PKCδ) are sensitized following nerve injury and promote pain-related responses in mice. The neural circuits underlying modulation of behaviors by CeA-PKCδ neurons, however, remain unknown. In this study, we identified a circuit that originates terminates the ventral region zona incerta (ZI), subthalamic structure previously linked to pain processing. Behavioral experiments show chemogenetic inhibition GABAergic ZI induced...
Abstract INTRODUCTION Depression is considered a prodromal state of Alzheimer's disease (AD), yet the underlying mechanism(s) by which depression increases risk AD are not known. METHODS Single‐nucleotide polymorphism (SNP) analysis was used to determine CALHM2 variants in patients. Cellular and molecular experiments were conducted investigate function V136G mutation. We generated new genetically engineered Calhm2 mouse model performed behavioral tests with these mice. RESULTS mutation...
Abstract The hypothalamus is a brain region with vital functions, and alterations in its development can cause human disease. However, we still do not have complete description of how this complex structure put together during embryonic early postnatal stages. Radially oriented, outside‐in migration cells prevalent the developing hypothalamus. In spite this, cell contingents from outside as well tangential hypothalamic migrations also an important role. Here study primordium by genetically...
This study aimed to assess the effect of hearing and speech rehabilitation in patients with Nurotron® cochlear implants.Ninety-eight paediatric bilateral severe-to-profound sensorineural deafness who received implantation were divided into three groups according age: group A (≤3 years), B (4-7 C (8-16 years). All followed up for one year performance after surgery. The comprehensive Auditory Perception Assessment, MAIS, CAP SIR assessments rating materials used assessment before surgery at 3,...
Rutin is a natural flavonoid, with typical effects including interaction enzymes and scavenging of free radicals. However, the role rutin in auditory system still unclear. In present study, we used neonatal organ Corti explants vitro to investigate cisplatin-induced ototoxicity. The TUNEL assay cleaved caspase-3 immunohistochemistry were detect apoptosis hair cell (HCs) cochlear explants, MitoSox-Red staining was difference mitochondrial superoxide among different groups. Western blot...
The inflammatory response plays a vital role in cerebral aneurysm (CA) formation and progression. Tanshinone IIA (Tan IIA) is one of the major active components Chinese medicine Danshen (Salvia miltiorrhiza Bunge) widely used for treatment cardiovascular diseases, due to its anti‑inflammatory effects. aim present study was investigate whether Tan can attenuate CA rat models, determine underlying mechanisms. CAs were induced rats surgically through high‑salt diet treatments. IIA‑treated group...
The present study examines the hypothesis that endogenous neural progenitor cells isolated from neocortex of ischemic brain can differentiate into neurons or glial and contribute to regeneration. We performed middle cerebral artery occlusion establish a model ischemia/reperfusion injury in adult rats. Immunohistochemical staining cortex 1, 3, 7, 14 28 days after revealed double-positive for nestin sox-2 appeared injured 1 3 post-injury, were also positive fibrillary acidic protein. New...
Inner ear formation requires that a series of cell fate decisions and morphogenetic events occur in precise temporal spatial pattern. Previous studies have shown transcription factors, including Pax2, Sox2, Prox1, play important roles during the inner development. However, temporospatial expression patterns among these factors are poorly understood. In current study, we present comprehensive description profiles Prox1 auditory vestibular sensory organ development mice. Using...
Cingulin, a cytoplasmic element of tight junctions (TJs), is involved in maintenance the integrity epithelial and endothelial cells. However, role cingulin development auditory organs remains unclear. Zebrafish popular as model organism for hearing research. Using whole mount situ hybridization (WISH) experiment, we detected expression b posterior lateral line system (PLLs) zebrafish. We traced early progress zebrafish PLLs from 36 hpf to 72 hpf, found that inhibition by target morpholinos...
Permanent damage to hair cells (HCs) is the leading cause of sensory deafness. Supporting (SCs) are essential in restoration hearing mammals because they can proliferate and differentiate HCs. MDS1 EVI1 complex locus (MECOM) vital early development cell differentiation regulates TGF-β signaling pathway adapt pathophysiological events, such as hematopoietic proliferation, death. In addition, MECOM plays an role neurogenesis craniofacial development. However, cochlea its way regulate related...
To investigate the role of periotic mesenchyme (POM) in development sensory cells developing auditory epithelium. Developing epithelium with or without was isolated from mice at embryonic days 11.5 (E11.5), E12.5 and E13.5, respectively, cultured vitro to an equivalent E18.5's vivo. Then, explants were co-stained antibodies targeting myosin VIIA, Sox2 BrdU. More hair E11.5 + 7 DIV, 6 DIV E13.5 5 epithelia found upon culture POM (225.90 ± 62.44, 476.94 100.81, 1386.60 202.38, respectively)...
While NUSAP1's association with various tumors is established, its predictive value for prognosis and immunotherapy in lung adenocarcinoma (LUAD) remains unconfirmed. We analyzed Nucleolar Spindle-Associated Protein 1 (NUSAP1) gene expression TCGA GTEx datasets validated it clinicopathological tissues using qRT-PCR immunohistochemistry. Additionally, we investigated relationship patient across five GEO cohorts. The IMvigor210 cohort was utilized to explore efficacy. Furthermore, single-cell...
Kif15, a kinesin family member, is powerful in the formation of bipolar spindles. There emerging evidence indicating that Kif15 plays vital roles influencing growth axons and interference with progression tumor. However, function auditory organs remains unknown. The Western blotting test was used to examine effect downregulation by specific morpholino targeting (Kif15-MO). development inner ear posterior lateral line (PLL) system zebrafish under continuous observation from spawns 96 h...