A5039334769- Neural dynamics and brain function
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Regulation of Appetite and Obesity
- Zebrafish Biomedical Research Applications
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Circadian rhythm and melatonin
- RNA Interference and Gene Delivery
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Glycogen Storage Diseases and Myoclonus
- interferon and immune responses
- Lysosomal Storage Disorders Research
- Axon Guidance and Neuronal Signaling
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Tactile and Sensory Interactions
- Motor Control and Adaptation
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
Dana-Farber Cancer Institute
2023-2024
Harvard University
2024
Motiva (Finland)
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2024
National Institutes of Health
2024
National Institute of Mental Health
2020-2024
John Brown University
2023
Government of the United States of America
2023
Brown University
2022
UCSF Benioff Children's Hospital
2019
The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remain unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes in mouse brain. Additionally, multiplex fluorescent situ hybridization top marker genes...
The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process relies on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) is a midline thalamic shapes motivated behaviors via its projections accumbens (NAc)
Niemann-Pick Disease Type C (NPC) is an inherited, often fatal neurovisceral lysosomal storage disease characterized by cholesterol accumulation in every cell with few known treatments. Defects transport cause sequestration of unesterified within the endolysosomal system. The discovery that systemic administration hydroxypropyl-beta cyclodextrin (HPβPD) to NPC mice could release trapped from lysosomes, normalize levels liver, and prolong life, led expanded access use patients. HPβCD has been...
ABSTRACT Across mammalian species, new mothers undergo considerable behavioral changes to nurture their offspring and meet the caloric demands of milk production 1-5 . While many neural circuits underlying feeding parenting behaviors are well characterized 6-9 , it is unclear how these different interact adapt during lactation. Here, we transcriptomic in arcuate nucleus (ARC) medial preoptic area (MPOA) mouse hypothalamus response lactation hunger. Furthermore, showed that heightened...
The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remains unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes. Additionally, multiplex fluorescent in situ hybridization top marker genes revealed that...
Abstract Long noncoding RNAs (lncRNAs) constitute a significant portion of the human transcriptome, yet their precise role in tumor cells remains elusive. In our study focusing on multiple myeloma (MM), we employed CRISPR-Cas13d endonuclease's RNA-targeting capabilities to establish an innovative functional transcriptomics screening platform. This platform facilitated comprehensive identification tumor-promoting lncRNAs (tp-lncRNAs) MM and provided mechanistic insights. Utilizing RNA-seq...
The mediodorsal thalamus (MD) and adjacent midline nuclei are important for cognition mental illness, but their cellular composition is not well defined. Using single-nucleus spatial transcriptomics, we identified a conserved excitatory neuron gradient, with distinct mapping of individual clusters. One end the gradient was expanded in human MD compared to mice, which may be related expansion granular prefrontal cortex hominids. Moreover, neurons preferentially onto parvocellular division...
SUMMARY The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process is thought rely on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) a midline thalamic shapes motivated behaviors via its projections accumbens (NAc) 1–8 monitors state interoceptive inputs from...
The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process is thought rely on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) a midline thalamic shapes motivated behaviors via its projections accumbens (NAc) monitors state interoceptive inputs from hypothalamus brainstem....