A5034475567- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- RNA Research and Splicing
- Wheat and Barley Genetics and Pathology
- Genetic Mapping and Diversity in Plants and Animals
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- RNA regulation and disease
- Single-cell and spatial transcriptomics
- Schizophrenia research and treatment
- RNA Interference and Gene Delivery
- Plant Stress Responses and Tolerance
- Congenital heart defects research
- Virus-based gene therapy research
- Genetic Associations and Epidemiology
- Mental Health and Psychiatry
- Axon Guidance and Neuronal Signaling
- Hedgehog Signaling Pathway Studies
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
New York University
2019-2024
Hubei Academy of Agricultural Sciences
2015-2024
Ministry of Agriculture and Rural Affairs
2023-2024
King Abdullah University of Science and Technology
2024
New York University Abu Dhabi
2015-2024
National Institute of Mental Health
2021-2024
National Institutes of Health
2024
Harvard University
2023-2024
Southern University of Science and Technology
2024
Huzhou University
2023
Cerebral cortical functions are conducted by two general classes of neurons: glutamatergic projection neurons and GABAergic interneurons. Distinct interneuron subtypes serve distinct roles in modulating activity can be differentially affected diseases, but little is known about the mechanisms for generating their diversity. Recent evidence suggests that many interneurons originate within subcortical telencephalon then migrate tangentially into overlying cortex. To test hypothesis derived...
Abstract The homeodomain transcription factor Nkx2.1 is expressed in the pallidal (subcortical) telencephalon, including medial ganglionic eminence (MGE) and preoptic area. Studies have shown that required for normal patterning of MGE specification parvalbumin (PV)‐ somatostatin (SST)‐expressing cortical interneurons. To define contribution lineages to neurons mature we generated transgenic mice carrying genomic integration a modified bacterial artificial chromosome (BAC) which second exon...
In the ventral telencephalon, medial ganglionic eminence (MGE) is a major source of cortical interneurons. Expression transcription factor NKX2.1 in MGE required for specification two subgroups interneurons - those that express parvalbumin (PV) or somatostatin (SST) but direct targets remain to be established. We find electroporation Nkx2.1 cDNA into telencephalon slice cultures from Nkx2.1-/- mouse embryos, followed by transplantation neonatal cortex permit postnatal analysis their fate,...
Fate determination in the mammalian forebrain, where mature phenotypes are often not achieved until postnatal stages of development, has been an elusive topic study despite its relevance to neuropsychiatric disease. In ventral telencephalon, major subgroups cerebral cortical interneurons originate medial ganglionic eminence (MGE), signaling molecule sonic hedgehog (Shh) continues be expressed during period neuronogenesis. To examine whether Shh regulates interneuron specification, we studied...
Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant therapy have been applied to the treatment of esophageal squamous cell carcinoma (ESCC). However, optimal regimen needs be further explored, particularly for older patients, and mechanisms by which immune inhibitor modulates evolution ESCC are unknown.In this single-arm phase 2 trial, patients resectable (stage II/III/IV without metastasis) were enrolled received nanoparticle albumin-bound (nab) paclitaxel two cycles...
SUMMARY In recent years, we and others have identified a number of enhancers that, when incorporated into rAAV vectors, can restrict the transgene expression to particular neuronal populations. Yet, viral tools access manipulate fine subtypes are still limited. Here, performed systematic analysis single cell genomic data identify enhancer candidates for each cortical interneuron subtypes. We established set enhancer-AAV that highly specific distinct populations striatal cholinergic neurons....
Significance Hippocampal hyperactivity predicts psychosis and may disrupt aspects of cognition in schizophrenia. Here, we use interneuron precursor transplants mice lacking cyclin D2 ( Ccnd2 ) to test links between hippocampal GABAergic interneurons psychosis-relevant phenotypes. -null show parvalbumin deficits increased vivo excitatory neuron spiking metabolic activity. This disinhibition is associated with cognitive excess dopamine Transplanting progenitors derived from the embryonic...
The present study was performed to evaluate the effects of seed priming. This done by soaking seeds two rapeseed cultivars, namely, ZY15 (tolerant low temperature and drought) HY49 (sensitive drought), for 12 h in varying solutions: distilled water, 138 mg/L salicylic acid (SA), 300 gibberellic (GA), 89.4 sodium nitroprusside (SNP), 3000 calcium chloride (CaCl2), 30 abscisic (ABA). Primed non-primed were left germinate at 15°C -0.15 MPa (T15W15) 25°C 0 (T25W0), respectively. results showed...
Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant thought to form canonical circuits regardless of which area they embedded in. Here, we investigate whether this is achieved through selective systematic variations their afferent connectivity during development. To end, examined development...
Abstract During brain development, neural circuits undergo major activity-dependent restructuring. Circuit wiring mainly occurs through synaptic strengthening following the Hebbian “fire together, wire together” precept. However, select connections, essential for circuit are transient. They effectively connected early in but strongly diminish during maturation. The mechanisms by which transient connectivity recedes unknown. To investigate this process, we characterize thalamocortical inputs,...
Objective: CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), is involved in cognition through interneuron modulation of dopamine and glutamate signaling. CHRNA7 its partially duplicated chimeric gene CHRFAM7A have been implicated schizophrenia linkage association studies. Method: Expression mRNA was measured the postmortem prefrontal cortex more than 700 subjects, including patients with schizophrenia, bipolar disorder, major depression, normal comparison subjects. The effects...
Abstract Fragile X syndrome (FXS), the leading cause of inherited intellectual disability and autism spectrum disorder, is associated with multiple neurobehavioral abnormalities including sleep difficulties. Nonetheless, frequency, severity, consequences problems are still unclear. The Online Registry Accessible Research Database (FORWARD‐ version ‐3), Clinician Report Parent forms, was analyzed for relationship behavioral problems, impact difficulties in a mainly pediatric cohort. A focused...
Abstract The mammalian cerebral cortex comprises a complex neuronal network that maintains delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own research, have shown specific interneuron subtypes are closely associated with particular pyramidal neuron types, forming stereotyped local microcircuits. However, the developmental processes establish these precise networks not well understood. Here we show types instrumental in driving...
ABSTRACT: The aromatic composition and key odorants of young red wines produced from Cabernet Sauvignon, Franc, Gernischet were compared the reasons for difference in their compounds discussed. Forty‐three detected Sauvignon Franc to 50 wine. Quantitatively, acids formed most abundant group components 3 wines, followed by alcohols esters. Compared profiles esters wine more diverse. Monoterpenes, namely, 4‐terpinenol, citronellol, nerol, found solely Only 10 compounds, ethyl octanoate,...
Medial ganglionic eminence (MGE)-derived GABAergic cortical interneurons (cINs) consist of multiple subtypes that are involved in many functions. They also have a remarkable capacity to migrate, survive and integrate into circuitry after transplantation postnatal cortex. These features engendered considerable interest generating distinct subgroups from pluripotent stem cells (PSCs) for the study interneuron fate function, development cell-based therapies. Although advances been made,...
Leaf color variations are common in plants. Herein we describe a natural mutant of barley cultivar Edamai No.6, whs18, whose leaf showed stable and inheritable stage-green-revertible-albino under field condition.Bulked Segregant Analysis (BSA) based on SSR assay Specific Length Amplified Fragment Sequencing (SLAF-seq) was used to map the candidate gene for this trait.We found that whs18 green at seedling stage, while seventh or eighth began show etiolation, albino leaves emerged after short...