A5003200952- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- RNA modifications and cancer
- Photoreceptor and optogenetics research
- Genetics and Neurodevelopmental Disorders
- Molecular Communication and Nanonetworks
- RNA and protein synthesis mechanisms
- ATP Synthase and ATPases Research
Harvard University
2021-2023
Broad Institute
2021-2023
Boston VA Research Institute
2022-2023
Stanley Foundation
2023
Stanley Center for Psychiatric Research
2021
Neuroscience Institute
2019
New York Proton Center
2019
New York University
2019
Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant thought to form canonical circuits regardless of which area they embedded in. Here, we investigate whether this is achieved through selective systematic variations their afferent connectivity during development. To end, examined development...
Somatostatin interneurons are the earliest born population of cortical inhibitory cells. They crucial to support normal brain development and function; however, mechanisms underlying their integration into nascent circuitry not well understood. In this study, we begin by demonstrating that maturation somatostatin in mouse somatosensory cortex is activity dependent. We then investigated relationship between activity, alternative splicing, synapse formation within population. Specifically,...
SUMMARY The cardinal interneuron classes are a useful simplification of cortical diversity, but such broad subgroupings glosses over the molecular, morphological, and circuit specificity subtypes, most notably among somatostatin class. organizing principles by which connectivity these subtypes is specified unknown. To address this knowledge gap, we designed series genetic strategies to target breadth subtypes. Using three that span entire column, examined their afferent efferent...
Abstract Somatostatin interneurons are the earliest born population of cortical inhibitory cells. They crucial to support normal brain development and function; however, mechanisms underlying their integration into nascent circuitry not well understood. In this study, we begin by demonstrating that maturation somatostatin is activity dependent. We then investigated relationship between activity, alternative splicing synapse formation within population. Specifically, discovered Nova family...
The cardinal interneuron classes are a useful simplification of cortical diversity, but such broad subgroupings glosses over the molecular, morphological, and circuit specificity subtypes, most notably among somatostatin class. organizing principles by which connectivity these subtypes is specified unknown. To address this knowledge gap, we designed series genetic strategies to target breadth subtypes. Using three that span entire column, examined their afferent efferent connectivity. Our...