A5085908217- Proteoglycans and glycosaminoglycans research
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Tuberculosis Research and Epidemiology
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
- Antibiotics Pharmacokinetics and Efficacy
- Photoreceptor and optogenetics research
- Protease and Inhibitor Mechanisms
- RNA regulation and disease
- Plant Reproductive Biology
- RNA Research and Splicing
- Cell Image Analysis Techniques
- Mosquito-borne diseases and control
- Genomic variations and chromosomal abnormalities
- Antibiotic Resistance in Bacteria
- Neurogenetic and Muscular Disorders Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Neural dynamics and brain function
- bioluminescence and chemiluminescence research
- Connective tissue disorders research
- Retinal Development and Disorders
- Bat Biology and Ecology Studies
Institute for Learning Innovation
2021
University of Florida
2021
NYU Langone Health
2016-2020
University of Pennsylvania
2015-2020
Children's Hospital of Philadelphia
2012-2020
New York University
2019
University of Nevada, Reno
2013
Stanford University
2004
The Arabidopsis thaliana genome contains 20 CNGCs, which are proposed to encode cyclic nucleotide gated, non-selective, Ca2+-permeable ion channels. CNGC7 and CNGC8 the two most similar with 74% protein sequence identity, both genes preferentially expressed in pollen. Two independent loss-of-function T-DNA insertions were identified for used generate plant lines only one of alleles was segregating (e.g., cngc7-1+/−/cngc8-2−/− cngc7-3−/−/cngc8-1+/−). While normal pollen transmission observed...
Summary Objective We previously reported loss of perineuronal net ( PN ) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus rats after an episode status epilepticus SE ). hypothesized that could alter seizure susceptibility and matrix metalloproteinases MMP s) were candidates for degradation following . Methods The pilocarpine chemoconvulsant rodent epilepsy model was used to characterize aggrecan component SE. Chondroitinase ABC (Ch degrade mice. Onset,...
In the rodent model of temporal lobe epilepsy, there is extensive synaptic reorganization within hippocampus following a single prolonged seizure event, after which animals eventually develop epilepsy. The perineuronal net (PN), component neural extracellular matrix (ECM), primarily surrounds inhibitory interneurons and, under normal conditions, restricts reorganization. objective current study was to explore effects status epilepticus (SE) on PNs in adult hippocampus. aggrecan PN studied,...
Significance Chemogenic activation of interneurons can bring about unexpected short-term and long-term changes in circuit dynamics. DREADD all interneuron types suppressed firing pyramidal cells but, unexpectedly, individual did not display sustained but instead undulated rates, interleaved with other interneurons. Despite the tonic suppression spikes neurons, population bursts underlying sharp wave ripples persisted, often stronger synchrony. Repeated drug application induced progressively...
The transcription factor Aristaless-related X-linked gene (Arx) is a monogenic in early onset epileptic encephalopathies (EOEEs) and fundamental regulator of stages brain development. However, Arx expression persists mature GABAergic neurons with an unknown role. To address this issue, we generated conditional knockout (CKO) mouse which postnatal was ablated parvalbumin interneurons (PVIs). Electroencephalogram (EEG) recordings CKO mice revealed increase theta oscillations the occurrence...
The repurposed agent moxifloxacin has become an important addition to the physician's armamentarium for therapy of Mycobacterium tuberculosis When a drug is administered, we need have metrics success. As most antimicrobial chemotherapy, contend that therapy, these should be decline in susceptible bacterial burden and suppression amplification less-susceptible populations. To achieve optimal outcomes relative metrics, dose schedule administration chosen. For large populations patients, there...
Mycobacterium tuberculosis metabolic state affects the response to therapy. Quantifying effect of antimicrobials in acid and nonreplicating phases M. growth will help optimize therapy for tuberculosis.
Would you know what to do if someone had a seizure? Do seizure looks like? More than 50 million people around the globe have epilepsy. Epilepsy is brain disorder in which patient has seizures. one of most common disorders, but also misunderstood. Patients with epilepsy are often met fear and confusion, because others not fully understand or how help who having seizure. Myths linked spirits gods. These myths influenced types first-aid practices treatments for seizures and. In this article,...
The transcription factor Aristaless-related X-linked gene (Arx) is a monogenic in early-onset epileptic encephalopathies (EOEEs) and fundamental regulator of early stages brain development. However, Arx expression persists mature GABAergic neurons, but its role the unknown. To address this issue, we generated conditional knockout (CKO) mouse which postnatal was selectively ablated parvalbumin interneurons (PVIs). Electroencephalogram (EEG) recordings CKO mice revealed an increase hippocampal...