A5020810570- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Advanced biosensing and bioanalysis techniques
- Connexins and lens biology
- Carbon and Quantum Dots Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Immune cells in cancer
- Electrowetting and Microfluidic Technologies
- Microfluidic and Bio-sensing Technologies
- Molecular Sensors and Ion Detection
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Lower Extremity Biomechanics and Pathologies
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Circular RNAs in diseases
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Retinal Diseases and Treatments
- Migraine and Headache Studies
Washington University in St. Louis
2007-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Xuzhou Medical College
2022-2024
Affiliated Eye Hospital of Wenzhou Medical College
2020-2022
Wenzhou Medical University
2020-2022
Beihang University
2021-2022
Harvard University
2020-2021
Broad Institute
2021
Boston VA Research Institute
2021
Shanghai Institute of Technology
2021
Abstract The utilization of semiconductor quantum dots (QDs) as optical labels for biosensing and biorecognition has made substantial progress. However, the development a suitable QD‐based luminescent probe that is capable detecting individual reactive oxygen species (ROS) represents great challenge, mainly because fluorescence QDs quenched by wide variety ROS. To overcome this limitation, novel turn‐on specific detection . OH been designed, its application in monitoring endogenous release...
There is currently great interest in developing chemiluminescence (CL) probes that can selectively detect peroxynitrite (ONOO(-)) living cells. In comparison with other reactive oxygen species (ROS), ONOO(-) spontaneously decompose into a series of radicals. Notably, the interaction quantum dots (QDs) oxidizing/reducing ROS radicals generate strong CL emission by electron-transfer annihilation. Herein, we report novel probe affords ability to distinguish from activate luminescence QDs...
Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render hippocampus hyperexcitable chronically (in epilepsy) or acutely status epilepticus) poorly understood. Recent evidence suggests substance P (SP), a peptide has been implicated cardiovascular function, inflammatory responses, and nociception , also contributes to excitability epilepticus, part by enhancing glutamate release. Here we report mice disruption of preprotachykinin A gene,...
Synaptic transmission at CNS synapses is often mediated by joint actions of multiple Ca(2+) channel subtypes, most prominently, P/Q- and N-type. We have proposed that P/Q-type channels saturate type-preferring slots presynaptic terminals, which impose a ceiling on the synaptic efficacy channels. To test for analogous interactions N-type channels, we overexpressed their pore-forming Ca(V)2.2 subunit in cultured mouse hippocampal neurons, recorded excitatory from transfected cells, dissected...
The prevalence of reactive oxygen species (ROS) production and the enzyme-containing intracellular environment could lead to fluorescence quenching bovine serum albumin (BSA)-capped gold nanoclusters (AuNCs). Here we report an efficient strategy address this issue, where a polymer-like shielding layer is designed wrap around Au core significantly improve stability AuNCs against ROS protease degradation. key our design covalently incorporate thiolated AuNC into BSA-AuNC via...
Exercise is beneficial for muscle atrophy. Peroxisome proliferator-activated receptor gamma (PPARγ) and microRNA-29b (miR-29b) have been reported to be responsible angiotensinⅡ (AngⅡ)-induced However, it unclear whether exercise can protect AngⅡ-induced atrophy by targeting PPARγ/miR-29b. Skeletal in both the control group run was established AngⅡ infusion; after 1 week of training, mice were sacrificed, weight determined. Myofiber size measured hematoxylin-eosin wheat-germ agglutinin...
In view of the magnetically actuated capsule robot applications in diagnoses human stomach disease, challenges that are associated with degrees-of-freedom (DOF), environmental adaptability, and size entire system must be addressed. this study, a new electromagnetic coil is based on adaptive magnetic levitation presented; it mainly composed an independent orientation control coil. The designed to perform motion capsule, including 3-DOF levitating translational control, pitch yaw levitation....
Non-contact manipulation technology has a wide range of applications in the and fabrication micro/nanomaterials. However, devices are often complex, operated only by professionals, limited single function. Here, we propose simple versatile optoelectronic tweezer (OET) system that can be easily controlled for manipulating microparticles with different sizes. In this work, designed established an system. The OET could used to manipulate particles sizes from 2 μm 150 μm. also micro-objects...
Future long-duration space missions will involve travel outside of the Earth's magnetosphere, which result in increased radiation exposure for astronauts. Exposure could permanently damage multiple tissues, including central nervous system (CNS), and deleterious effects on cognition behavior during beyond mission. Here, we assessed whole-body oxygen ion (16O; 1,000 MeV/n) (5 or 25 cGy) social odor recognition memory male Long-Evans rats at one six months after exposure. At month...
Abstract Prostate cancer (PCa) remains the secondary highest cause of cancer‐related death in United States men. It has been reported that microRNAs can serve as key regulators tumor development and progression various cancers including PCa. In this study, we examined effect miR‐498 on proliferation, radiosensitivity, invasion, migration PCa cells. The proliferation LNCaP DU‐145 cells with altered expression was evaluated by MTT assay. invasion were assess matrigel assay transwell protein...
Abstract PD‐1/PD‐L1 inhibitors have emerged as standard treatments for advanced solid tumors; however, challenges such a low overall response rate and systemic side effects impede their implementation. Hypoxia drives the remodeling of tumor microenvironment, which is leading reason failure immunotherapies. Despite some reported strategies to alleviate hypoxia, individual limitations constrain further improvements. Herein, novel two‐pronged strategy presented efficiently address hypoxia by...
Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion activation peripheral regulatory T cells (Tregs) in mice. In this study, we investigated molecular mechanisms underlying effects LD-IL-2 Treg cells. increases production cytokines interleukin-10 (IL-10) transforming growth factor beta-1 (TGFβ1) cells, especially suggesting that they may mediate...
In this work, it was found that cationic surfactant cetyltrimethylammonium bromide (CTAB)-modified montomorillonite (MMT) can significantly amplify chemiluminescence (CL) from the peroxynitrite system. Transmission electron microscopy (TEM), scanning microscope (SEM), powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), ζ potential measurements and differential thermogravimetry (DTG) analyses confirmed geometrical configuration of CTAB at surface MMT. addition,...
Purpose: We used a mouse model to explore the role of endoplasmic reticulum membrane protein complex subunit 3 (EMC3) in mammalian retinal development. Methods: The transcription pattern Emc3 C57BL/6 mice was analyzed by situ hybridization. To effects EMC3 absence on development, Cre-loxP system generate retina-specific knockout (Emc3flox/flox, Six3-cre+; CKO). Morphological changes retina E13.5, E17.5, P0.5, and P7 were observed via hematoxylin eosin staining. Immunofluorescence staining...
Abstract The utilization of semiconductor quantum dots (QDs) as optical labels for biosensing and biorecognition has made substantial progress. However, the development a suitable QD‐based luminescent probe that is capable detecting individual reactive oxygen species (ROS) represents great challenge, mainly because fluorescence QDs quenched by wide variety ROS. To overcome this limitation, novel turn‐on specific detection . OH been designed, its application in monitoring endogenous release...
TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown function as a steroid-activated, heat-sensitive calcium ion (Ca2+) channel. A missense substitution (p.I65M) in gene humans (TRPM3) mice (Trpm3) underlie an inherited form early-onset, progressive cataract. Here, we model pathogenetic effects this cataract-causing mutation using ‘knock-in’ mutant human cell lines. Trpm3 its intron-hosted micro-RNA (Mir204) were strongly...
Medication overuse headache (MOH) is the most common secondary disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have shown that peripheral C-C motif ligand 2 (CCL2), chemokine receptor (CCR2) calcitonin-gene-related peptide (CGRP) signaling pathways interact with each other play critical roles in development migraine-related behavioral cellular sensitization. present investigated whether CCL2-CCR2 CGRP role...