A5103003427- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Parathyroid Disorders and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Traditional Chinese Medicine Analysis
- Head and Neck Anomalies
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Cancer Immunotherapy and Biomarkers
- Vestibular and auditory disorders
- Airway Management and Intubation Techniques
- Wnt/β-catenin signaling in development and cancer
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Pituitary Gland Disorders and Treatments
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Studies
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Xi'an Jiaotong University
2013-2024
Qingdao University
2019-2023
Affiliated Hospital of Qingdao University
2019-2023
Tianjin Medical University
2018-2022
Second Hospital of Tianjin Medical University
2018-2022
Tianjin University
2018-2022
Xi'an Jiaotong University
2008-2022
Tianjin University of Traditional Chinese Medicine
2018-2021
Baoji City Central Hospital
2008
Shenzhen Maternity and Child Healthcare Hospital
2004
Abstract Background RING Finger Protein 115 (RNF115), a notable E3 ligase, is known to modulate tumorigenesis and metastasis. In our investigation, we endeavor unravel the putative function inherent mechanism through which RNF115 influences evolution of thyroid carcinoma (THCA). Methods We analyzed expression in THCA using Cancer Genome Atlas (TCGA) database. The influence on progression was evaluated both vitro vivo experimental approaches. protein regulated by identified bioinformatics...
Background: This study aims to investigate the role of ferroptosis in hypertrophic cardiomyopathy (HCM), a genetic disorder characterized by abnormal thickening heart muscle. The objective is identify differentially expressed genes associated with HCM and understand potential molecular mechanisms underlying disease. Methods: Comprehensive genomic analysis was conducted HCM. focused on TFRC, SCD, SLC2A1, EGR1, GDF15, SNCA, PLIN2, NQO1 as hub regulating ferroptosis. Functional enrichment...
Background Hashimoto’s thyroiditis (HT) is the most prevalent inflammatory disorder of thyroid gland. Current studies have reported coexistence rate between HT and papillary carcinoma (PTC) quite high. The objective this study was to evaluate impact on predictive factors central compartment lymph node metastasis (CLNM) in PTC. Methods A retrospective investigation performed PTC patients. They were subclassified into non-HT groups. results preoperative neck ultrasound (US) examinations...
Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer derived from parafollicular C cells in the gland. It has great interest as research focus because of its unusual genetic, clinical, and prognostic characteristics. However, pathogenesis MTC not completely clear. We investigated role miR-9-3p bladder cancer-associated protein (BLCAP) TT cells. First, expression was upregulated human tissues compared to control by RT-PCR. Flow cytometric analysis indicated that cell cycle progression...
Abstract Objectives Tongue squamous cell carcinoma (TSCC) is the most common malignancy in oral cancer. Long noncoding RNAs (lncRNAs) are important regulators cancer biology. In our present study, we investigated a novel lncRNA IGF‐like family member 2 antisense RNA 1 (IGFL2‐AS1) TSCC. Methods RT‐qPCR analyzed IGFL2‐AS1 expression TSCC cells. Functional assays assessed impact of on proliferation, migration, and invasion. Western blot protein levels EMT‐related markers. Mechanism regulatory...
Abstract Background To evaluate the efficacy of a sensitive, real-time tool for identification and protection parathyroid glands during thyroidectomy. Methods Near-infrared (NIR) auto-fluorescence was measured intraoperatively from 20 patients undergoing Spectra were suspicious surrounding neck tissues operation with NIR fluorescence system. Fast frozen sections performed on glands. Accuracy evaluated by comparison histology identification. Data attracted Fisher’s linear discriminant...
Abstract PD‐1/PD‐L1 inhibitors have emerged as standard treatments for advanced solid tumors; however, challenges such a low overall response rate and systemic side effects impede their implementation. Hypoxia drives the remodeling of tumor microenvironment, which is leading reason failure immunotherapies. Despite some reported strategies to alleviate hypoxia, individual limitations constrain further improvements. Herein, novel two‐pronged strategy presented efficiently address hypoxia by...
Myocardial infarction (MI) is a common and multifactorial disease that has the highest morbidity mortality in world. Although number of physiological, pathological, functional parameters have been investigated, only scarce information regarding changes small metabolites plasma reported, this lack may cause poor MI diagnosis treatment. In present study, we aimed to investigate metabolic profiles samples from patients identify potential biomarkers study pathology MI. Metabolic thirty controls...
Objectives: The purpose of this study was to propose an integrated strategy for investigating the mechanism Qiliqiangxin capsule (QLQX) treat chronic heart failure (CHF). Methods: Pharmacokinetics analysis performed screen active components QLQX using high-performance liquid chromatography-tandem mass spectrometry techniques. We then constructed component-target network between targets in and CHF Cytoscape. A analysis, including topological parameters, clustering, pathway enrichment,...
Artemisia annua is the most common outdoor aeroallergen throughout Northern China; however, no multicenter study has investigated sublingual immunotherapy (SLIT) as a treatment option for annua-induced allergic rhinitis (AR). The aim of this was to evaluate efficacy and safety an innovative SLIT annua-related AR.This randomized, double-blind, placebo-controlled, multicenter, phase 3 clinical trial conducted in China (NCT XXX). A total 702 annua-sensitized eligible patients were randomized...
Abstract Background Parathyroid protection and central neck dissection (CND) are basic points of thyroid cancer surgery draw persistent concern. We aimed to evaluate the value carbon nanoparticles (CNs) for parathyroid gland CND in patients. Methods A total 386 consecutive patients were enrolled retrospective study. Three hundred thirty-four using CNs intraoperatively included CN group, 52 without or any other helping agent control group. Intact hormone (iPTH) was examined. Medical records...
Oridonin, derived from Rabdosia rubescens, has exhibited anticancer activity in a variety of cancers.However, few studies have explored the effect oridonin (ORI) on migration, invasion and epithelial-mesenchymal transition (EMT) nasopharyngeal carcinoma.In our study, results demonstrated that significantly inhibited migration human carcinoma CNE-2Z HNE-1 cell lines, as depicted by wound healing Transwell assays.In addition, increased expression E-Cadherin while decreased expressions vimentin...
Lymph node metastasis is an important step in the progression of colorectal cancer (CRC); however, underlying mechanisms are still unknown. The aim present study was to identify gene expression pattern during lymph CRC and upstream microRNAs (miRNAs) explore detail. A total 305 differently expressed genes (DEGs) were identified, including 227 upregulated 78 downregulated metastasis. Pathway process enrichment analysis demonstrated that DEGs significantly enriched 'NABA CORE MATRISOME',...
Multidrug resistance (MDR) is a major obstacle to the efficacy of hepatocellular carcinoma (HCC) chemotherapy. Previous studies have identified that low FZD3 predicted decreased survival after intraperitoneal versus intravenous-only chemotherapy in ovarian cancer. This study aimed identify potential target HCC The expression variant cell lines was detected by RT-qPCR and western blotting. early recurrent group (RE group) non-early (non-RE measured RT-qPCR. Then, 50% inhibitory concentrations...
The aim of this study was to investigate the effect microRNA (miR)‑145 on proliferation, migration and invasion human oral cancer line, TCA8113. Expression levels miR‑145 in TCA8113 cells were detected by quantitative PCR. transfected into abilities treated assays, respectively. expression significantly lower than those normal keratinocytes (P<0.05). Cellular transfection group control (all P<0.05). High found negatively regulate cells. Results present indicate that may be associated with...
Oridonin, a bioactive diterpenoid derived from Rabdosia rubescens, has been widely reported to exhibit anticancer activity in multiple types of cancer. However, the molecular mechanism oridonin human laryngeal carcinoma not clearly elucidated. This study investigated function provide research basis for therapy. The proliferation Hep-2 and TU212 cells treated with was determined by MTT assay. apoptotic induction effect on analyzed flow cytometry, Western blot analysis caspase3 In addition,...