A5020255669- Autophagy in Disease and Therapy
- Bioactive Natural Diterpenoids Research
- MicroRNA in disease regulation
- Dental Implant Techniques and Outcomes
- Cell death mechanisms and regulation
- Hedgehog Signaling Pathway Studies
- Berberine and alkaloids research
- Nigella sativa pharmacological applications
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- Orthodontics and Dentofacial Orthopedics
- Genetic factors in colorectal cancer
- Temporomandibular Joint Disorders
- Thyroid Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Dental Radiography and Imaging
- Total Knee Arthroplasty Outcomes
- Healthcare Operations and Scheduling Optimization
- Chemotherapy-induced organ toxicity mitigation
- Sexual function and dysfunction studies
- Direction-of-Arrival Estimation Techniques
- Synthesis and bioactivity of alkaloids
- Brain Tumor Detection and Classification
- Hippo pathway signaling and YAP/TAZ
First Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Xi'an Jiaotong University
2017-2023
First Hospital of Xi'an
2014-2022
Air Force Medical University
2021
Chinese Academy of Sciences
2010-2019
Qingdao Center of Resource Chemistry and New Materials
2012-2019
Guilin University of Technology
2019
Fujian Institute of Research on the Structure of Matter
2019
State Key Laboratory of Structural Chemistry
2019
First Hospital of Shijiazhuang
2017
Generally, the emergence of Internet Things enabled applications inspired world during last few years, providing state-of-the-art and novel-based solutions for different problems. This evolutionary field is mainly lead by wireless sensor network, radio frequency identification, smart mobile technologies. Among others, IoT plays a key role in form medical devices wearables, with ability to collect varied longitudinal patient-generated health data, at same time also offering preliminary...
Oridonin, a bioactive diterpenoid isolated from Rabdosia rubescens, has been reported to exert anticancer activity in various cancers. However, the molecular mechanism of oridonin thyroid cancer not yet elucidated. In present study, was found significantly inhibit migration and invasion TPC-1 BCPAP cells, as evidenced by wound healing assay, transwell assay Matrigel assay. addition, could partially impede epithelial-mesenchymal transition upregulating E-Cadherin expression downregulating...
Tetrandrine (TET), a traditional Chinese medicine, exerts remarkable anticancer activity on various cancer cells. However, little is known about the effect of TET human prostate cells, and mechanism function has not yet been elucidated. To investigate effects suppression proliferation, induction apoptosis, inhibition migration invasion in cell lines, DU145 PC-3. Inhibition growth was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay clone formation assay, flow...
Hedgehog (Hh) signaling pathway is considered to play a crucial role in vertebrate development and carcinogenesis. Additionally, epithelial-mesenchymal transition (EMT) cellular process during which epithelial cells become mesenchymal-appearing cells, facilitating cancer metastasis invasion. Accumulating evidence has indicated that the Hh could potentiate (EMT). In present study, we demonstrated tetrandrine, bisbenzylisoquinoline alkaloid isolated from Stephaniae, exerts its anti-metastatic...
Chemotherapy as a cornerstone of cancer treatment is slowly being edged aside owing to its severe side effects and systemic toxicity. In this case, nanomedicine has emerged an effective tool address these drawbacks. Herein, biocompatible carrier based on bovine serum albumin (BSA) coated gadolinium oxide nanoparticles (Gd2O3@BSA) was fabricated for curcumin (CUR) delivery physicochemical features along with potential anticancer activity against nasal squamous cell carcinoma were also...
We present an instructional design strategy to tune the optical absorption ability of organic-inorganic hybrids by managing internal iodide state. Three bismuth-based with different states were synthesized and display tunable bandgaps from 1.91 eV 1.87 finally 1.59 eV.
The aim of the present study was to determine cardioprotective mechanisms by which micro (mi)RNA-30e protects heart from myocardial ischemia/reperfusion injury (MI/R) and explore signaling pathways that may confer protection for be potential therapeutic targets. It demonstrated miRNA‑30e expression decreased in patients with MI/R. In H9C2 cells, silencing (si)miRNA‑30e significantly inhibited cellular apoptosis, apoptosis regulator BAX (Bax) caspase‑3 activity. also increased...
Thymoquinone, isolated from the seeds of Nigella sativa, has exhibited antitumor properties in a variety cancer types. However, few studies have investigated effect thymoquinone (TQ) on migration and invasion renal cell carcinoma (RCC). In present study, our results confirmed that TQ significantly inhibited human RCC 769‑P 786‑O lines, as demonstrated by wound healing Transwell assays. Additionally, upregulated expression E‑cadherin downregulated Snail, ZEB1 vimentin at mRNA protein levels...
Oridonin is the main bioactive component of Rabdosia rubescens, and its anticancer activity has been reported in a variety cancers.However, molecular mechanism oridonin laryngeal carcinoma remains unclear.In present study, cytotoxic effect on Hep-2 TU212 cell lines were initially detected by modified MTT assay.The results showed that had dose-dependent anti-proliferative cells.Next, we found significantly inhibited migration invasion human wound healing assay transwell assay.Subsequently,...
High-mobility group AT-hook 2 (HMGA2), a member of the high mobility family, has been reported to correlate with cancer progression. However, there is no report concerning correlation between HMGA2 and metastasis in renal cell carcinoma. In present study, we found that was highly expressed five carcinoma lines compared normal tubular epithelial HK2 line. Additionally, facilitated migration invasion cells, as evidenced by wound healing Transwell assays. Subsequently, our results revealed...
Oridonin, derived from Rabdosia rubescens, has exhibited anticancer activity in a variety of cancers.However, few studies have explored the effect oridonin (ORI) on migration, invasion and epithelial-mesenchymal transition (EMT) nasopharyngeal carcinoma.In our study, results demonstrated that significantly inhibited migration human carcinoma CNE-2Z HNE-1 cell lines, as depicted by wound healing Transwell assays.In addition, increased expression E-Cadherin while decreased expressions vimentin...
Oridonin, a bioactive diterpenoid derived from Rabdosia rubescens, has been widely reported to exhibit anticancer activity in multiple types of cancer. However, the molecular mechanism oridonin human laryngeal carcinoma not clearly elucidated. This study investigated function provide research basis for therapy. The proliferation Hep-2 and TU212 cells treated with was determined by MTT assay. apoptotic induction effect on analyzed flow cytometry, Western blot analysis caspase3 In addition,...
Purpose: Liver kinase B1 (LKB1), also known as serine/threonine 11, was considered a tumor suppressor, which exhibited anti-cancer activity in variety of cancers. However, the effect LKB1 thyroid cancer remains unclear. Methods: In study, MTT assay, colony formation flow cytometry, western blot analysis, wound healing transwell assays, quantitative real-time PCR, HUVEC migration ELISA tube assay and nude mice xenograft were used to investigate capacity vitro vivo. Results: present we found...
Taraxasterol (TAR) is a kind of active compound extracted from dandelion and its molecular structure resembles steroid hormones. Recently, TAR has been reported to show an anti-tumor activity. However, the specific role in papillary thyroid cancer (PTC) not clarified. In this study, we investigated effect on PTC cell migration, invasion epithelial-to-mesenchymal transition (EMT) induced by TGF-β1. cells were exposed TGF-β1 (5 ng/mL) then treated with different concentrations TAR. We found...
Existing sensor array signal processing techniques always use linear arrays sampled at Nyquist rate which demands the inter-element spacing is less than or equal to half of system wavelength. Only in this way can algorithms such as MUSIC, Capon's beamformer estimate direction-of-arrival (DOA) sources unambiguously. However, some practical use, it seems difficult satisfy spatial sampling theorem. Compressed Sensing (CS) a novel theory enables perfect recovery signals and data from what appear...
This study aimed to investigate the correlations among androgen receptor (AR) CAG repeat polymorphism, sex hormones and penile length in healthy Chinese young adult men. Two hundred fifty-three men (aged 22.8 ± 3.1 years) were enrolled. The individuals grouped as short (CAGS) if they harbored of ≤20 or long (CAGL) their was >20. Body height/weight, other parameters examined recorded by specified physicians; polymorphism determined polymerase chain reaction (PCR) method; serum levels detected...