A5100345473- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Mass Spectrometry Techniques and Applications
- Natural Compounds in Disease Treatment
- Ginseng Biological Effects and Applications
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
- Chromatography in Natural Products
- Healthcare and Venom Research
- Spectroscopy and Chemometric Analyses
- Advanced Proteomics Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Ginkgo biloba and Cashew Applications
- Flavonoids in Medical Research
- Molecular Sensors and Ion Detection
- Dermatology and Skin Diseases
- Gastrointestinal motility and disorders
- Pain Management and Placebo Effect
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
Tarim University
2025
Shanxi University of Traditional Chinese Medicine
2022-2025
Soochow University
2011-2024
Jianghan University
2022-2024
Guizhou University
2024
Northwestern Polytechnical University
2024
Chengdu University
2023
Shenyang Pharmaceutical University
2009-2023
Guangdong Pharmaceutical University
2023
Southern University of Science and Technology
2023
Abstract Background Danshen (Salvia miltiorrhiza Bunge), also known as Chinese red sage, is a member of Lamiaceae family. It valued in traditional medicine, primarily for the treatment cardiovascular and cerebrovascular diseases. Because its pharmacological potential, ongoing research aims to identify novel bioactive compounds danshen, their biosynthetic pathways. To date, only expressed sequence tag (EST) RNA-seq data this herbal plant are available public. We therefore propose that...
A promising two-photon fluorescent probe MNAH for detecting<sup>1</sup>O<sub>2</sub>during the PDT process in mitochondria was proposed first time.
Triptolide, the predominant biologically active component of Chinese herb Tripterygium wilfordii Hook f., possesses numerous pharmacological activities, including anti-inflammatory, anti-fertility, anti-neoplastic, and immunosuppressive effects. However, toxicity severe adverse effects, particularly hepatotoxicity, limit clinical application triptolide. Licorice root extract contains various bioactive compounds is potent hepatoprotective. Magnesium isoglycyrrhizinate, a magnesium salt...
This article primarily develops a new technology for the rapid large-scale screening of isoliquiritigenin-transforming strains based on MTHM (microplate reader–TLC–HPLC–UPLC-MS) method. ISO is chalcone compound with potential pharmacological activity, and its rich substitution sites benzene ring provide solid foundation structural modification drug development. study screened approximately 1500 employed microplate reader, thin-layer chromatography, high-performance liquid mass spectrometry...
Purpose: The objective of this research is to delve into the central pathological mechanisms involved in transformation from acute chronic pain. Patients and Methods: This study enrolled 86 individuals with neck pain 89 Utilizing a 3.0T MR scanner, we obtained three-dimensional T1-weighted imaging (3D-T1WI) images analyzed structural differences between two groups Freesurfer software evaluate alterations cortical thickness. Additionally, Blood Oxygen Level-Dependent functional Magnetic...
Chromatographic fingerprint technology has become the standard of quality control for traditional herbal medicines (THMs). But several issues are associated with wavelength selection representative fingerprint, such as contradictory evaluation results at different wavelengths and accurate quantification each composition one wavelength. These problems can be addressed by projection profiling. Projection profiling is a collection all sample compositions maximum absorption after baseline...
Mandipropamid (MDP) is a widely used chiral fungicide to control oomycete pathogens with two enantiomers. In this study, the enantioselective bioactivity, toxicity, and degradation of MDP were investigated for first time. The bioactivity S-MDP was 118-592 times higher than that R-MDP 1.14-1.67 Rac-MDP against six phytopathogens. Molecular docking found formed strong halogen bond HIS 693 cellulose synthase possessed lower binding energy, which validated results assay. showed toxicity toward...
Homocysteine (Hcy) is one of the independent risk factors cardiovascular disease. Sodium tanshinone IIA sulfonate (STS) a hydrophilic derivate which main active constitute Chinese Materia Medica Salviae Miltiorrhizae Radix et Rhizoma, and exhibits multiple pharmacological activities. However, whether STS could prevent from Hcy-induced endothelial cell injury unknown. We found that dramatically reversed death concentration dependently in human umbilical vascular cells (HUVECs). ameliorated...
Background Patients with atopic dermatitis (AD) exhibit phenotypic variability in ethnicity and IgE status. In addition, some patients develop other allergic conditions, such as rhinitis (AR), subsequent life. Understanding the heterogeneity of AD would be beneficial to phenotype-specific therapies. Methods Twenty-eight Chinese 8 healthy volunteers were enrolled study. High-throughput transcriptome sequencing was conducted on lesional nonlesional skin samples from 10 matched normal 5...
Kidney-yang-deficiency-syndrome is a neuroendocrine disease caused by the dysfunction of adrenal-pituitary-target gland axis. Gushudan traditional Chinese medicine prescription with functions tonifying kidney and strengthening bone, its bone-strengthening effect has been confirmed previous anti-osteoporosis research. However, kidney-tonifying mechanism not clear so far. In this study, renal metabolomics lipidomics based on gas chromatography-mass spectrometry ultra-high-performance liquid...
Thymoquinone, isolated from the seeds of Nigella sativa, has exhibited antitumor properties in a variety cancer types. However, few studies have investigated effect thymoquinone (TQ) on migration and invasion renal cell carcinoma (RCC). In present study, our results confirmed that TQ significantly inhibited human RCC 769‑P 786‑O lines, as demonstrated by wound healing Transwell assays. Additionally, upregulated expression E‑cadherin downregulated Snail, ZEB1 vimentin at mRNA protein levels...
Objective: Paeoniae Radix Rubra (PRR) is a commonly used traditional Chinese medicine with the effects of clearing away heat, cooling blood, and relieving blood stasis. To 1) elucidate metabolites metabolic pathways PRR its 14 main constituents in mice 2) reveal possible origins known effective forms their isomers, metabolism was systematically studied for first time. Methods: were administered to by gavage once day seven consecutive days, respectively. All urine feces collected during 7...
Determining the binding mechanism of HYP and lipase by multi-spectral techniques, isothermal titration calorimetry, enzyme kinetics molecular simulations provided a new direction for screening natural inhibitors.
A micellar electrokinetic chromatography fingerprint coupled with quantification was developed for assessing the quality consistency of Danshen tablets, a traditional Chinese medicine, pharmacological activities activating blood to remove stasis and regulating flow vital energy alleviate pain. Square optimization method proposed select suitable background electrolyte. Subsequently, index chromatographic fingerprints F simultaneously employed as an objective function evaluate capillary...
In this paper, microemulsion electrokinetic chromatography (MEEKC) fingerprints combined with quantification were successfully developed to monitor the holistic quality consistency of Ixeris sonchifolia (Bge.) Hance Injection (ISHI). ISHI is a Chinese traditional patent medicine used for its anti-inflammatory and hemostatic effects. The effects five crucial experimental variables on MEEKC optimized by central composite design. Under conditions, 28 ISHIs developed. Quantitative determination...
Traditional Chinese medicines/herbal medicines (TCM/HM) are too complicated mixture systems to investigate their quality consistency effectively using a single detection technique.