A5100422279- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Chromatography
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Carbohydrate Chemistry and Synthesis
- Pesticide Residue Analysis and Safety
- Catalytic Alkyne Reactions
- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- Genetic and phenotypic traits in livestock
- Pharmacological Effects and Toxicity Studies
- Bamboo properties and applications
- Atrial Fibrillation Management and Outcomes
- Natural Fiber Reinforced Composites
- Adipose Tissue and Metabolism
- Molecular Sensors and Ion Detection
- Ultrasound Imaging and Elastography
- Lipoproteins and Cardiovascular Health
- Calpain Protease Function and Regulation
- Asymmetric Hydrogenation and Catalysis
- Nitric Oxide and Endothelin Effects
- Pharmacogenetics and Drug Metabolism
- Cancer, Lipids, and Metabolism
- Lignin and Wood Chemistry
Zhejiang University
2014-2025
Advanced Research Institute
2025
Nanjing Drum Tower Hospital
2025
Ministry of Industry and Information Technology
2023-2025
Beijing Institute of Technology
2023-2025
Army Medical University
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2025
Nanjing Medical University
2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Gemischtes Doppel: Bei der hoch regioselektiven C3-Heteroarylierung eines Indols oder Pyrrols mit einer Vielzahl elektronenreicher und -armer N-Heteroarene, für die ein Palladium-Kupfer-Cokatalysatorsystem eingesetzt wird, liefert doppelte C-H-Aktivierung selektiv das unsymmetrische Diheteroaryl nicht Homokupplungsprodukte.
Doxorubicin (Dox) is a widely used antitumor agent with dose-dependent and cumulative cardiotoxic effects. Resveratrol (Res) natural non-flavonoid polyphenol that can potentially provide cardiovascular benefits. We aimed to estimate the protective effect of Res on Dox-induced cardiotoxicity (DIC) explore whether it was related attenuating ferroptosis. established DIC models in C57BL/6 J mice, H9C2 cardiomyoblasts, neonatal rat cardiomyocytes (NRCMs). further treated cells RSL3, ferroptosis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInstallation of Electron-Donating Protective Groups, a Strategy for Glycosylating Unreactive Thioglycosyl Acceptors using the Preactivation-Based Glycosylation Method (1)Youlin Zeng†, Zhen Wang†, Dennis Whitfield‡, and Xuefei Huang*†View Author Information Department Chemistry, Michigan State University, East Lansing, 48824, Institute Biological Sciences, National Research Council Canada, 100 Sussex Dr., Ottawa, Ontario K1A 0R6, Canada[email...
Cross-coupling: the "chelation-directed control" and "catalytic-system-based strategies effectively switch C2/C3-site selectivity in heteroarylation of indoles pyrroles with N-heteroarenes by a palladium-catalyzed twofold C-H activation to form biheteroarenes are further extended synthesis complex fused tri- tetracyclic heteroarenes tandem fourfold activation.
Abstract Background Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have implicated in telomere shortening or preservation; however, the association between remains controversial. To address this issue, we conducted Mendelian randomization (MR) analysis to investigate potential causal associations multiple length. Methods Independent genetic variants strongly associated (tobacco smoking,...
A visual and fluorogenic detection method for a nerve agent simulant was developed based on Lossen rearrangement of rhodamine–hydroxamate, in the presence diethyl chlorophosphate, under alkaline conditions.
A Pd/Cu-catalyzed dehydrogenative Heck coupling is established that allows direct alkenylation of various biologically relevant N-heteroarenes with alkenes. The resulting π-extended alkenylated exhibit interesting fluorescent properties and have proven to be potentially useful probes for bioimaging.
An unusual Rh/Cu-catalyzed synthesis of pyrido[2,1-a]indoles starting from 1-(pyridin-2-yl)-1H-indoles and γ-substituted propargyl alcohols was presented. The multi-step cascade transformations formally involve the cleavage two C-H, three C-C, one C-N bonds with concomitant construction four excellent chemoselectivity in one-pot reaction.
It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better those who undergo hypofractionated stereotactic radiation therapy (HSRT) than surgery. However, the reason HSRT a OS not fully explored. Here, we analyzed reconstitution kinetics immune cells peripheral blood of NSCLC after HSRT. We found increased frequency total T cells, especially proportion CD8+ but decreased inhibitory Tregs. Intracellular staining showed HSRT,...
Abstract Pigs not only function as a major meat source worldwide but also are commonly used an animal model for studying human complex traits. A large haplotype reference panel has been to facilitate efficient phasing and imputation of relatively sparse genome-wide microarray chips low-coverage sequencing data. Using the imputed genotypes in downstream analysis, such GWASs, TWASs, eQTL mapping genomic prediction (GS), is beneficial obtaining novel findings. However, currently, there still...
Pydiflumetofen (PYD), a highly effective and broad-spectrum fungicide, is commonly employed for the control of fungal diseases. In this study, uptake, translocation, biotransformation PYD by wheat (Triticum aestivum L.) were firstly investigated at chiral level. The findings revealed that residue concentration R-PYD in was higher than S-PYD, because its uptake rate (k1=0.0421 h-1) lower elimination (k2=0.0459 h-1). Additionally, exhibited root bioconcentration factors translocation compared...
Abstract Due to individual differences, accurate identification of tissue elastic parameters is essential for biomechanical modeling in surgical guidance hepatic venous injections. This paper aims acquire the absolute Young's modulus heterogeneous soft tissues during endoscopic surgery with 2D ultrasound images. First, we introduced a force-sensor-less approach that utilizes pre-calibrated patch known and its images calculate external forces exerted by probe on tissue. Second, Kriging-based...
Background: Fixed drug eruption (FDE) is a hypersensitivity reaction caused by antibiotics and non-steroidal anti-inflammatory drugs primarily. Antondine injection used to reduce fever, mainly composed of aminopyrine, antipyrine barbiturate, its adverse reactions include anaphylactic shock, epidermolysis, rash, agranulocytosis, etc. FDE an uncommon phenomenon, the these ingredients has been reported in current case report. However, fatal severe fixed it not reported. Here, we report PDE...
Abstract Liver regeneration is critical for maintaining whole‐body homeostasis, especially under exposure to deadly chemical toxins. Understanding the molecular mechanisms underlying liver repair development of intervention strategies treat diseases. In this study, ubiquitin‐specific Proteases 42 (USP42) identified as a novel deubiquitinases (DUB) peroxisome proliferators‐activated receptor γ (PPARγ) in hepatocytes. This DUB interacted, deubiquitinated, and stabilized PPARγ, increased PPARγ...