A5023633716- RNA modifications and cancer
- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Thyroid Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Ear Surgery and Otitis Media
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- interferon and immune responses
- Head and Neck Cancer Studies
- Tactile and Sensory Interactions
- Obstructive Sleep Apnea Research
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related gene regulation
- MRI in cancer diagnosis
First Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Chinese PLA General Hospital
2019-2024
Jilin Province Tumor Hospital
2024
Harbin Medical University
2016-2023
First Affiliated Hospital of Harbin Medical University
2016-2023
Peking University
2021-2022
Peking University People's Hospital
2021-2022
Third Affiliated Hospital of Harbin Medical University
2018-2021
Southern Medical University
2021
Nanfang Hospital
2021
Abstract Background Macrophage-like transformation of vascular smooth muscle cells (VSMCs) is a risk factor atherosclerosis (AS) progression. Transcription homeobox A1 (HOXA1) plays functional roles in differentiation and development. This study aims to explore the role HOXA1 VSMC transformation, thereby providing evidence for potential mechanism AS pathogenesis. Methods High fat diet (HFD)-fed apolipoprotein E knockout (ApoE −/− ) mice were applied as an vivo model imitate AS, while...
The metabolic profiling of biofluids using untargeted metabolomics provides a promising choice to discover metabolite biomarkers for clinical cancer diagnosis. However, discovered in may not necessarily reflect the pathological status tumor tissue, which makes these difficult reproduce. In this study, we developed new analysis strategy by integrating univariate and multivariate correlation approach tissue derived (TTD) metabolites plasma samples. Specifically, was first used profile set...
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain...
Lung cancer is the leading cause of death in China and around world. Early detection key to improving survival rate non-small cell lung (NSCLC). Alteration glycosylation has been observed cancers, glycans can be a source for development new biomarkers NSCLC.In this glycan biomarker discovery study, we measured serum N- O-glycan profiles NSCLC patients with different stages healthy controls by performing lectin microarray analysis. The alterations glycopatterns were compared between controls,...
Non-segmental vitiligo (NSV) is a chronic autoimmune disease characterized by progressive depigmentation of the skin. Oxidative stress (OS) has been proposed as one among main principal causes in development and establishment sustained state patients with NSV. However, disease-associated OS biomarkers clinical practice are not well studied. In this study, we found significantly reduced antioxidant enzymes [catalase (CAT) superoxide dismutase (SOD)], total capacity (TAC), increased levels...
Abstract Background Parathyroid protection and central neck dissection (CND) are basic points of thyroid cancer surgery draw persistent concern. We aimed to evaluate the value carbon nanoparticles (CNs) for parathyroid gland CND in patients. Methods A total 386 consecutive patients were enrolled retrospective study. Three hundred thirty-four using CNs intraoperatively included CN group, 52 without or any other helping agent control group. Intact hormone (iPTH) was examined. Medical records...
Circulating tumor cells (CTCs) are present in the bloodstream, which originate from sites, and ultimately responsible for metastasis or relapse several types of cancer. However, to best our knowledge, only a few studies have investigated these extremely rare esophageal squamous cell carcinoma (ESCC). In study, 63 patients with ESCC 50 healthy donors were recruited, potential clinical significance CTCs was assessed using subtraction enrichment immunostaining‑fluorescence situ hybridization....
To investigate the effects of conductive hearing loss (CHL) on vestibular evoked myogenic potentials (VEMPs) using a simulated CHL model, and to provide basis for future studies.Twenty-one healthy subjects were recruited in this study. We measured ocular VEMPs (oVEMPs) cervical (cVEMPs) these by air-conduction sound (ACS) stimulation. was later blocking right external auditory canal with soundproof earplug evaluate its impacts VEMPs. Subjects' responses before served as control, compared...
Taraxasterol (TAR) is a kind of active compound extracted from dandelion and its molecular structure resembles steroid hormones. Recently, TAR has been reported to show an anti-tumor activity. However, the specific role in papillary thyroid cancer (PTC) not clarified. In this study, we investigated effect on PTC cell migration, invasion epithelial-to-mesenchymal transition (EMT) induced by TGF-β1. cells were exposed TGF-β1 (5 ng/mL) then treated with different concentrations TAR. We found...
Raman spectra integrated multiple potential biomarkers into one spectroscopic signature for the diagnosis of RA. In recognition ACPA-negative RA, sensitivity and specificity also reached 95.6% 92.8%, respectively.
Thyroid cancer is the most common malignancy of endocrine system. Circular RNA (circRNA) recognized as a key regulator tumorigenesis in papillary thyroid carcinoma (PTC). Here this work focused on mechanism circRNA_0003892 (circ_0003892) PTC progression.Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine circ_0003892, microRNA-326 (miR-326) and LIM SH3 protein 1 (LASP1) mRNA expression levels tissues cell lines. Besides, counting kit-8 (CCK-8), EdU transwell assays...
Background: Thyroid cancer is the most common endocrine malignancy and fastest growing worldwide. has largest genetic component of all cancers. Previous genome-wide association studies indicated that polymorphism in PCNXL2 related to thyroid susceptibility European populations. This study aims determine influence polymorphisms on risk Chinese individuals. Methods: case–control identified four among 510 cases 509 healthy controls. The associations with were detected by calculating odds...
Nucleotide excision repair (NER) plays a critical role in the development of smoking-related cancers. We hypothesize that mRNA expression levels NER genes are associated with risk squamous cell carcinoma head and neck (SCCHN). To test this hypothesis, we conducted case-control study 260 SCCHN patients 246 cancer-free controls by measuring eight core cultured peripheral lymphocytes. Compared controls, cases had statistically significantly lower DDB1 ERCC3 (P = 0.015 0.041, respectively)....
Squamous cell carcinoma of head and neck (SCCHN) is one the most common malignancies worldwide, nucleotide excision repair (NER) involved in SCCHN susceptibility. In this analysis 349 newly diagnosed patients 295 cancer‐free controls, we investigated whether expression levels eight core NER proteins were associated with risk SCCHN. We quantified protein cultured peripheral lymphocytes using a reverse‐phase microarray. Compared had statistically significantly lower ERCC3 XPA ( P = 0.001...