A5088804527- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Natural Language Processing Techniques
- MicroRNA in disease regulation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Toxin Mechanisms and Immunotoxins
- Inflammasome and immune disorders
- Biomedical Text Mining and Ontologies
- Circular RNAs in diseases
- Advanced Biosensing Techniques and Applications
- vaccines and immunoinformatics approaches
- Topic Modeling
Peking University
2022-2025
Peking University People's Hospital
2022-2025
Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third patients with RA could not be accurately diagnosed because lacking biomarkers. Our recent study reported that scavenger receptor-A (SR-A) a biomarker for RA, especially anticyclic citrullinated peptide antibody (anti-CCP)–negative RA. Here, we further identified the B cell autoantigenic epitopes SR-A. By large-scale multicenter including one training three validation cohorts 1954...
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease triggered by antigenic peptides with environmental and genetic risk factors. It has been shown that antigen-specific targeting could be a promising therapeutical strategy for RA restoring immune tolerance to self-antigens without compromising normal immunity. Citrullination of antigens enhances properties induces responses. Here, we showed citrullinated (citAg) vaccine ameliorated collagen-induced decreased T-helper 1 (Th1) Th17...
Raman spectra integrated multiple potential biomarkers into one spectroscopic signature for the diagnosis of RA. In recognition ACPA-negative RA, sensitivity and specificity also reached 95.6% 92.8%, respectively.
Objective Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of systemic lupus erythematosus (SLE) patients. Hsa_circ_0000479 has been studied the field cancer and infection, whereas seldom autoimmune diseases. The aim this study was to investigate role clinical value neutrophil hsa_circ_0000479 SLE.
The routine biomarkers for rheumatoid arthritis (RA), including anticyclic citrullinated peptide antibody (anti-CCP), factor (RF), immunoglobulin M (IgM), erythrocyte sedimentation rate (ESR), and C-reaction protein (CRP) have limited sensitivity specificity. Scavenger receptor-A (SR-A) is a novel RA biomarker identified by our group recently, especially seronegative RA. Here, we performed large-scale multicentre study to further assess the diagnostic value of SR-A in combination with other
The study aimed to investigate the serum antigenomic profiling in rheumatoid arthritis (RA) and determine potential diagnostic biomarkers using label-free proteomic technology implemented with machine-learning algorithm.