A5101644657- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Glaucoma and retinal disorders
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Intraocular Surgery and Lenses
- Infrared Thermography in Medicine
- Photoacoustic and Ultrasonic Imaging
- Traumatic Ocular and Foreign Body Injuries
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- Retinal and Macular Surgery
- Retinal Diseases and Treatments
- Cardiac Valve Diseases and Treatments
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Thermoregulation and physiological responses
- Retinopathy of Prematurity Studies
- Ocular and Laser Science Research
- RNA modifications and cancer
- Aortic aneurysm repair treatments
- Moyamoya disease diagnosis and treatment
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Antiplatelet Therapy and Cardiovascular Diseases
Xinqiao Hospital
2016-2025
Army Medical University
2013-2025
Jiangmen Central Hospital
2020-2025
Harbin Medical University
2025
Third Affiliated Hospital of Harbin Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2020-2023
Dalian Medical University
2020-2023
Fujian Medical University
2021-2023
Chongqing Medical University
2020-2023
First Affiliated Hospital of Fujian Medical University
2021-2023
Reperfusion therapy for myocardial infarction is limited by significant re-occlusion rates and less-than-optimal tissue perfusion. It was the objective of this study to assess compare effect ticagrelor, first reversibly binding oral P2Y12 receptor antagonist, with that clopidogrel, in conjunction thrombolytic therapy, on platelet aggregation, thrombus formation, perfusion a canine model. Thrombus formation induced electrolytic injury blood flow measured Doppler ultrasonic flowmeter. All...
Serum albumin level is a reliable and convenient marker of the nutritional status patients, has been identified as prognostic in glioblastoma. However, because recent wide application standard radio-chemotherapy for treatment glioblastoma effect preoperative serum levels needs to be re-evaluated related mechanism should further explored.A total 214 patients with histologically proven who underwent at our institution between 2009 2012 were retrospectively analyzed. Clinical information was...
Abstract Aberrant expression of grainyhead‐like transcription factor 3 (GRHL3) has been extensively reported in the development and progression several squamous cell carcinomas, such as cutaneous, head neck, esophageal carcinoma. However, clinical significance biological roles GRHL3 lung (LUSC) carcinoma are largely unclear. Herein, we report that was significantly upregulated epithelium LUSC tissues, bronchiole, bronchus. Moreover, levels were decreased with advance pathological grade, low...
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain...
Abstract Purpose This study aimed to explore circular RNA (circRNA) hsa_circ_0000690 as a potential biomarker for diagnosis and prognosis of intracranial aneurysm (IA) its relationship with clinical factors complications IA. Material/methods 216 IA patients admitted the neurosurgery department our hospital from January 2019 December 2020 were selected experimental group, 186 healthy volunteers control group. The expression in peripheral blood was detected by quantitative real‐time PCR,...
Ample cell adhesion to scaffolds is essential for effective bone tissue engineering. Chitosan/hydroxyapatite (CS/HA) with channel-shaped and spherically shaped pore morphologies were prepared via in situ compositing hybridization combination lyophilization. The sizes of pores the CS/HA 150–650 µm 3–15 µm, respectively. RGD peptide (Arg-Gly-Asp) was bound surface physical adsorption. More than 63% present a PBS solution spontaneously adsorbed onto scaffolds. High numbers viable marrow stromal...
Primary multiple intracranial aneurysm (MIA) is a vascular disease that frequently leads to fatal rupture and subarachnoid hemorrhage. However, the epigenetic regulation associated with MIA has remained largely elusive. Circular RNAs (circRNAs) serve important roles in cardiovascular diseases; however, their association be investigated. The present study initially aimed explore novel mechanisms of through examining circRNA expression profiles. Comprehensive profiles were detected by RNA...
Non-small cell lung cancer (NSCLC) continues to top the list of mortalities worldwide. Early diagnosis and therapeutic interventions targeting NSCLC is becoming world's significant challenge. Circular RNAs (circRNAs) are emerging as a group potential biomarkers.Quantitative real-time PCR (qRT-PCR) was employed examine expression circ_0072309 in tissues lines. Cell counting kit 8 (CCK-8), wound healing Transwell assays were used analyze proliferation, migration invasion A549 H1299 cells. The...
Abstract Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, glycoprotein (MAG), and oligodendrocyte-myelin (OMgp). MAIs have two co-receptors, Nogo receptor (NgR) paired immunoglobulin-like B (PirB). Existing studies confirm that inhibiting NgR only exerted a modest disinhibitory effect in CNS. However, PirB regeneration after binding to are controversial too. We aimed further...
Cherry-red spots are a very important sign for the clinical diagnosis of central retinal artery occlusion (CRAO). We retrospectively summarized manifestations CRAO and analysed causes characteristics without cherry-red spots. In this study, we explored diagnostic method cherry red spots.Seventy patients (70 eyes) with were examined retrospectively. Corrected distance visual acuity, fundus photos, FA OCT images collected at first outpatient visit. The through photos. incidence increased...
PurposeThe paired box gene 6 (PAX6) is an essential transcription factor for eye formation. Genetic alterations in PAX6 can lead to various ocular malformations including aniridia. The purpose of this study was identify genetic defects as the underlying cause familial coloboma a large Chinese family. MethodsAfter linkage analysis carried out family, all exons proband were sequenced by Sanger sequencing technique. Then genome evaluated microarray-based comparative genomic hybridization...
In-stent restenosis (ISR) is a major problem within stented arteries. Surface treatment of stents with platinum and gold were found to have the maximum charge least neointima formation (NF). This study was designed evaluate (maximum electrical charge) as material make reduce NF. Iridium added an alloy suitable for stent manufacture, potential radioactive. We implanted novel platinum-iridium (PI) in 10 porcine coronaries compared Palmaz-Schatz (PS) 8 coronary Six weeks after implantation,...
Aneurysmal subarachnoid hemorrhage is strongly associated with symptomatic cerebral vasospasm. This study aims to investigate whether a quantitative measure of aneurysmal hematoma by 3D Slicer more valuable for vasospasm risk prediction compared modified Fisher scale and the new Eagles.We performed retrospective research Digital Imaging Communications in Medicine format (DICOM) patients treated at our institution from 2019 2020. Association between volume was explored univariate multivariate...
Allergy and immunoglobulin E levels are inversely associated with glioma risk. Previous studies have focused on respiratory food allergies, little information is available regarding drug allergies. This study evaluated the rate of positive penicillin skin tests (PenSTs) blood eosinophil counts in a large population patients compared nontumor controls to provide evidence for relationship between allergies risk.A retrospective case-control was conducted diagnosed (n = 913) January 2004 June...
Summary Membrane electroporation (MEP) increases the electrical conductivity of plasma membrane by addition an external field. Combining MEP‐induced current ( I MEP ) with antineoplastic agents has been increasingly considered as a new therapeutic manoeuvre, especially in treatment malignant gliomas. Thus, aim present study was to evaluate effect AUY922 (AUY), potent inhibitor heat‐shock protein 90 (HSP90), on glioblastoma cells. The cells (U373) generated repetitive hyperpolarization from...
Polycystic ovary syndrome (PCOS), one of the most common types endocrine diseases, is characterized by a high prevalence among women reproductive-age. However, its pathogenesis and molecular mechanisms remain unclear. CircMTO1 has been reported to participate in numerous biological processes, but, role PCOS progression remains unknown. In current study, we elucidated expression circRNA characterization circMTO1 human granulosa-like tumor cells. We found that knockdown promoted cell...
Purpose: To use optical coherence tomography angiography (OCTA) to assess the pattern of changes in retinal and choroidal blood flow structure healthy volunteers who quickly went from sea level a plateau determine parameters associated with acute mountain sickness (AMS). Methods: Forty-five individuals (89 eyes) were examined by OCTA filled out AMS questionnaire. One baseline examination was performed on plain, followed examinations at days 1, 3, 5 after entering plateau. Parameters...
To introduce a novel approach in removal of anterior chamber angle foreign body (ACFB) using prism contact lens and 23-gauge forceps.Data 42 eyes patients who had undergone ACFB forceps from January 2008 to October 2013 were collected analyzed. Twenty group A received the conventional by toothed through corneal limbus incision, 22 B underwent method opposite incision.The success rate once was 75% (15/20) A, 100% (22/22) B. The average operation time significantly longer compared with...
The purpose of the present study was to characterize idiopathic epiretinal membrane (iERM) through proteomics and phosphoproteomics analysis facilitate diagnosis treatment iERM.The vitreous 25 patients with an iERM 15 macular hole were analyzed by proteomic phosphoproteomic based on tandem mass tag. PRM used verify differential proteins.Proteomic identified a total 878 proteins, including 50 proteins. Tenascin-C, galectin-3-binding protein, glucose-6-phosphate isomerase, neuroserpin,...
To evaluate the efficacy and safety of using coreoplasty, an iris-supported Artisan intraocular lens (IOL), for mydriasis aphakic correction in post-traumatic vitrectomized eyes.A total 17 patients were admitted between April 2009 2010 to ophthalmologic department Xiamen Eye Center. All eyes had previously received removal vitrectomy. After retina stabilized corrected visual acuity improved, iris was sutured. The IOL fixated onto surface. Patients followed-up at one day, week, month three...