A5100408709- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Axon Guidance and Neuronal Signaling
- NF-κB Signaling Pathways
- Spine and Intervertebral Disc Pathology
- Music Therapy and Health
- Inflammatory mediators and NSAID effects
- Aortic Disease and Treatment Approaches
- Natural product bioactivities and synthesis
- Medical Research and Treatments
- Animal Nutrition and Physiology
- Pediatric Pain Management Techniques
- Bone Metabolism and Diseases
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Diabetic Foot Ulcer Assessment and Management
- Metabolomics and Mass Spectrometry Studies
- Infant Development and Preterm Care
- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- Infant Health and Development
- Hip and Femur Fractures
Second Hospital of Hebei Medical University
2011-2022
Hebei Medical University
2011-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Wangjing Hospital of China Academy of Chinese Medical Sciences
2022
Henan Provincial Chest Hospital
2021
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2021
Ningbo Institute of Industrial Technology
2019-2021
Chinese Academy of Sciences
2019-2021
Ningbo University
2021
Guangzhou University
2019
Pluronic F127 diacrylate (F127DA) micelle-crosslinked methacrylated hyaluronic acid (MeHA) hydrogel with low-swelling and strong compressive properties was successfully synthesized for the regeneration of cartilages <italic>in vivo</italic>.
Repair of peripheral nerve defect presents a considerable challenge for reconstructive surgeons. The aim this study is to develop brain-derived neurotrophic factor (BDNF) from poly(D,L-lactide-co-glycolide) (PLGA) microspheres the treatment defect.BDNF were prepared by using an oil-in-water emulsification-solvent evaporation method. morphology, particle size, encapsulation efficiency, drug loading and sustained release performance was observed calculated. Adipose mesenchymal stem cells...
Although chemokine stromal cell-derived factor 1 (SDF-1) and its receptor CXCR4 induce degradation of articular cartilage in rheumatoid arthritis (RA) osteoarthritis (OA), the association between SDF-1/CXCR4 pathway cartilaginous endplate nucleus pulposus has not been thoroughly clarified. We investigated expression SDF-1 intervertebral discs (IVDs).SDF-1 levels human IVDs rat L5/6 motion segment were quantified by enzyme-linked immunosorbent assay. staining was using a microscope Image-Pro...
Tert-butylhydroquinone (tBHQ) has been identified as an inhibitor of oxidative stress-induced injury and apoptosis in human neural stem cells. However, the role tBHQ osteoarthritis (OA) is unclear. This study was carried out to investigate OA.OA animal model induced by destabilization medial meniscus (DMM). Different concentrations (25 50 mg/kg) were intraperitoneally injected ten-week-old female mice. Chondrocytes isolated from articular cartilage mice treated with 5 ng/ml...
Abstract Osteoarthritis (OA) is a common joint disease characterized by progressive cartilage degradation, in which elevated chondrocyte apoptosis and catabolic activity play an important role. MicroRNA‐155 (miR‐155) has recently been shown to regulate some pathological circumstances, yet, whether how miR‐155 associated with OA pathology remain unexplored. We report here that level significantly up‐regulated human biopsies also primary chondrocytes stimulated interleukin‐1β (IL‐1β), pivotal...
Corticosterone is one of the most crucial glucocorticoids (GCs) in poultry. Our previous study shows that corticosterone can retard longitudinal growth bones by depressing proliferation and differentiation chondrocytes broilers. The present was designed to investigate whether affect development synthesis collagen vitro. were isolated from proximal tibial plates 6-week-old broiler chickens cultured with different doses for 48 h. Then cell viability, alkaline phosphatase (ALP) activity...
Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary osteogenesis. It has been previously demonstrated that the CCAL1 locus gene encoding tumor necrosis factor receptor superfamily member 11B ( TNFRSF11B ). The purpose of this study was to demonstrate role in OA progression elucidate its molecular mechanisms. We report highly expressed patients expression level positively correlated with severity OA. found causes switch fibrosis‐prone...
Abstract Chondrocyte spheroids in 3D hydrogel are more beneficial to improve their survival and maintain chondrogenic phenotype comparing dissociated chondrocytes. However, in-situ inducing cell into rather than encapsulating a remains tremendous challenge because of the limitations biochemical viscoelastic controllability for hydrogel. Herein, consisting photo-crosslinkable chitosan methacrylate (CHMA) semi-interpenetrating polyvinyl alcohol (PVA) is developed as cell-responsive matrix with...
The most effective treatment for knee joint pain is total arthroplasty (TKA), but the risk of and swelling in patients after surgery high. Ice application, ankle pump exercise non-steroidal anti-inflammatory painkillers are primary clinical treatments surgery. However, long-term use relievers can easily cause gastrointestinal damage. Traditional Chinese medicine (TCM) ointments tuina therapy integrate TCM manipulation, which effectively promotes penetration into skin lesions, improves local...
Objective To investigate the effect of recombinant human erythropoietin(rh-EPO) on nerve regeneration adult rats sciatic nerves. Methods Tirty-six healthy male Wistar were involved and left repaired model was used.The experimental divided randomly into two groups:the EPO group control group,18 in each group.rh-EPO 3 000 U/kg injected daily abdominal group,and normal saline every day after operation group.On 4 8 weeks operation,these items determined,the function index (SFI),biomechanics...
Objective: This study analyzed the risk factors of neurological complications in patients with Stanford type A aortic dissection after Sun’s procedure a single-center purpose improving effects. Methods: From January 2019 to December 2020, clinical data 480 dissection, who were treated by our center retrospectively analyzed. Univariate and multivariate logistic regression analyses used determine postoperative complications. According whether there surgery, they divided into two groups: group...