A5100631612- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Child Nutrition and Water Access
- Antibiotic Resistance in Bacteria
- Infant Development and Preterm Care
- Breastfeeding Practices and Influences
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Enterobacteriaceae and Cronobacter Research
- Plant tissue culture and regeneration
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- Congenital heart defects research
- Heavy Metal Exposure and Toxicity
- Clinical Nutrition and Gastroenterology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutritional Studies and Diet
- Pharmaceutical and Antibiotic Environmental Impacts
- Congenital Anomalies and Fetal Surgery
- Trace Elements in Health
- Selenium in Biological Systems
- Vitamin C and Antioxidants Research
- Bacterial Genetics and Biotechnology
- Birth, Development, and Health
Children's Hospital of Fudan University
2016-2024
Institute of Botany
2013-2024
Xi'an Botanical Garden of Shaanxi Province
2012-2024
Chinese Center For Disease Control and Prevention
2018-2024
Jiangxi Agricultural University
2024
Yunnan Institute of Endemic Diseases Control and Prevention
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Sun Yat-sen University
2022-2023
China Agricultural University
2022
Hebei Medical University
2021
Objectives: To describe the rates and variability of mortality morbidity preterm infants born in China. Methods: This prospective cohort study included at <34 weeks' gestation admitted to 25 NICUs within 7 days birth between May 1st, 2015 April 30th, 2016. Infants were followed until death or NICU discharge. The primary outcome was a composite any major (sepsis, necrotizing enterocolitis, intraventricular /periventricular leukomalacia, retinopathy prematurity, bronchopulmonary dysplasia) who...
Nanomaterials possessing intrinsic enzyme-mimetic activity are becoming an important topic of current research. However, their is limited by the particle size nanomaterials. In this study, Pd nanoclusters with average 1.4 nm synthesized using a metal organic framework, zeolitic imidazolate framework-8 (ZIF-8), as matrix via impregnation-reaction method. By virtue confined channels ZIF-8 and strong chemical interaction between show high dispersity stability. The obtained Pd@ZIF-8 proven to...
Urinary tract infections (UTIs) are among the most common late-onset in preterm infants, characterized by nonspecific symptoms and a pathogenic spectrum that diverges from of term infants older children, which present unique diagnostic therapeutic challenges. Existing data on role gut microbiota UTI pathogenesis this demographic limited. This study aims to investigate alterations fecal calprotectin levels their association with development UTIs hospitalized infants. A longitudinal...
Background: This study aims to investigate the role of ferroptosis in hypertrophic cardiomyopathy (HCM), a genetic disorder characterized by abnormal thickening heart muscle. The objective is identify differentially expressed genes associated with HCM and understand potential molecular mechanisms underlying disease. Methods: Comprehensive genomic analysis was conducted HCM. focused on TFRC, SCD, SLC2A1, EGR1, GDF15, SNCA, PLIN2, NQO1 as hub regulating ferroptosis. Functional enrichment...
Background: Human milk is known to be rich in cellular components, including stem cells and immune cells. However, the dynamics of these components at different lactation stages, differences between for preterm term infants, are poorly understood. Research aim: To identify changes human explore associations with maternal infant characteristics. Methods: Forty mothers newborns gestational ages were enrolled. Colostrum, transitional, mature samples collected. Stem cell molecule markers...
OBJECTIVES To determine whether use, duration, and types of early antibiotics were associated with neonatal outcomes late antibiotic use in preterm infants without infection-related diseases. METHODS This cohort study enrolled admitted to 25 tertiary NICUs China within 24 hours birth during 2015–2018. Death, discharge, or morbidities 7 days birth; major congenital anomalies; error data on excluded. The composite outcome was death adverse morbidities. Late indicated used after age. rate total...
Neurological manifestations are potentially associated with hepatitis E virus (HEV) infection in Europe, mainly attributed to genotype (GT) 3 HEV infection. In this study, we determined the frequency and causal relationship of patients non-traumatic neurological disorders China, where GT4 is prevalent. 1117 consecutive diagnosed illnesses a hospital eastern China 1475 healthy controls who took routine examination same were tested for by serology molecular methods. Anti-HEV IgM antibodies...
Abstract The aim of this study is to determine the expression and roles miR‐346 in nasopharyngeal carcinoma (NPC). We showed that was upregulated NPC tissues compared with adjacent non‐tumorous tissues. Inhibition significantly attenuated migration invasion cells. Luciferase reporter assay targeted 3′‐untranslated region (3′‐UTR) breast cancer metastasis suppressor 1 (BRMS1). Overexpression suppressed endogenous BRMS1 There a significant negative correlation between protein ( r = −0.372, P...
The proliferation of vascular smooth muscle cells (VSMCs) induced by injury to the intima arteries is an important etiologic factor in proliferative disorders such as atherosclerosis and restenosis. Uncaria rhynchophylla traditional Chinese herb that has been applied treatment convulsive disorders, epilepsy, China. In present study, we examined whether corynoxeine exerts inhibitory effects on platelet-derived growth (PDGF)-BB-induced rat aortic VSMC possible mechanism effects. Pre-treatment...
Feeding intolerance (FI) is a significant concern in the care of preterm infants, impacting their growth and development. We previously reported that FI linked to lower fecal calprotectin (FC) levels. This study aims explore postnatal dynamics interplay between microbiota, metabolic profiles, host immunity infants with without FI.Infants gestational age <32 weeks or birth weight <1500 g were enrolled at Children's Hospital Fudan University January 2018 October 2020. Weekly samples analyzed...
To determine the dietary structure and its associated factors of tuberculosis (TB) patients in community. This cross-sectional study analysed intake 300 TB two impoverished counties China. Food was collected by using food frequency consecutive 24-h review (24hdr) methods. The composition were compared with China's 2022 Dietary Reference Intake (DRIs) average reference value (ARC) China 2013. Binary logistic regression models used to explore inadequate animal food, insufficient protein fat...
There is limited evidence about the influence of human milk feeding on short-term outcomes in a large preterm infant population.To explore influences primary outcome necrotizing enterocolitis and secondarily sepsis, bronchial pulmonary dysplasia, severe retinopathy prematurity, death, time to achieve full enteral at discharge very/extremely low-birth-weight infants.This study was retrospective, longitudinal, observational two-group comparison cohort study. A total 4470 infants from 25...
To elucidate the postnatal dynamics and clinical associations of fecal calprotectin (FC) in very preterm infants, with a focus on necrotizing enterocolitis (NEC) feeding intolerance (FI).We performed prospective observational cohort study infants gestational age <32 weeks or birth weight <1,500 g weekly feces collection. The relationships between FC, NEC, FI were investigated, adjusting for demographic factors.A total 1,086 samples collected from 194 infants. Postnatal FC levels non-NEC...
Bacterial meningitis is a serious central nervous system infection associated with high morbidity and mortality during the neonatal period, while pathogen distribution was rarely reported on large scale in China. This study aimed to investigate change trends of bacterial pathogens Children's Hospital Fudan University over past 12 years.This retrospective included all cases diagnosed admitted our hospital from 2009 2020.Totally 231 were enrolled, including 128 (55.4%) for male, 72 (31.2%)...
Keshan disease (KD) is a type of endemic cardiomyopathy with an unknown cause. It primarily found in areas China low selenium levels, from northeast to southwest. The nutritional biogeochemical etiology hypothesis suggests that deficiency major factor KD development. Selenium important removing free radicals and protecting cells tissues peroxide-induced damage. Thus, environmental may affect the level within human body, differences are commonly observed between healthy people nonKD areas....
Objective Neonatal meningitis significantly contributes to neonatal morbidity and mortality, yet large-scale epidemiological data in developing countries, particularly among very preterm infants (VPIs), remain sparse. This study aimed describe the epidemiology of VPIs China. Design Cross-sectional using Chinese Network database from 2019 2021. Setting 79 tertiary intensive care units Patients Infants with gestational age <32 weeks or birth weight <1500 g. Main outcome measures...
Scheme of the cell metabolomics strategy workflow.
The optimal treatment strategy for patent ductus arteriosus (PDA) in extremely preterm infants is currently highly controversial. This study aimed to evaluate the association between PDA and short-term outcomes among infants.This cohort included all (≤27 6/7 weeks) who were admitted hospitals participating Chinese Neonatal Network from January 2019 December 2021, diagnosed have by echocardiogram. was defined as medical and/or surgical ligation of during hospitalization. Short-term death,...