A5103266360- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Selenium in Biological Systems
- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Trace Elements in Health
- Biochemical Analysis and Sensing Techniques
- Pesticide and Herbicide Environmental Studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- MicroRNA in disease regulation
- Antibiotics Pharmacokinetics and Efficacy
- Heavy metals in environment
- Nanoplatforms for cancer theranostics
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Infant Nutrition and Health
- Neonatal Health and Biochemistry
- Pancreatitis Pathology and Treatment
- Catalytic Alkyne Reactions
- Cannabis and Cannabinoid Research
Innovation Team (China)
2014-2024
Harbin Medical University
2015-2024
First Affiliated Hospital of Nanchang University
2023-2024
China-Japan Friendship Hospital
2023-2024
Nanchang University
2023-2024
Northwest University
2024
Ministry of Education of the People's Republic of China
2024
Institute of Endemic Disease Control in Shandong Province
2010-2023
Affiliated Hospital of Guizhou Medical University
2022
Guiyang Medical University
2022
Antimicrobial efficacy, which is central to many aspects of medicine, being rapidly eroded by bacterial resistance. Since new resistance can be induced antimicrobial action, highly lethal agents that reduce burden during infection should help restrict the emergence To improve activity, recent work has focused on toxic reactive oxygen species (ROS) as part bactericidal activity diverse antimicrobials. We report when Escherichia coli was subjected stress and stressor subsequently removed, both...
A potential pathway linking hydroxyl radicals to antimicrobial lethality was examined by using mutational and chemical perturbations of Escherichia coli. Deficiencies sodA or sodB had no effect on norfloxacin lethality; however, the absence both genes together reduced lethal activity, consistent with rapid conversion excessive superoxide hydrogen peroxide contributing quinolone lethality. Norfloxacin more a mutant deficient in katG than its isogenic parent, suggesting that detoxification...
Stress-mediated programmed cell death (PCD) in bacteria has recently attracted attention, largely because it raises novel possibilities for controlling pathogens. How PCD is regulated to avoid population extinction due transient, moderate stress remains a central question. Here, we report that the YihE protein kinase key regulator protects Escherichia coli from antimicrobial and environmental stressors by antagonizing MazEF toxin-antitoxin module. was linked reactive oxygen species (ROS)...
Sucralose is a calorie-free high-intensity artificial sweetener that widely used in thousands of foods and beverages all over the world. Although it had been initially regarded as safe inert food additive, its adverse effect on gut microbiota health has drawn more attention evidence accumulates. Studies by us others revealed sucralose exacerbated damage inflammation animal models for inflammatory bowel disease (IBD) including both ulcerative colitis Crohn's disease. Our study demonstrated...
Perturbation of hydroxyl radical accumulation by subinhibitory concentrations 2,2'-bipyridyl plus thiourea protects Escherichia coli from being killed 3 lethal antimicrobial classes. Here, we show that delays and/or reduces killing Staphylococcus aureus daptomycin, moxifloxacin, and oxacillin. While the protective effect varied among strains compounds, data support hypothesis enhances lethality.
Reactive oxygen species (ROS; superoxide, peroxide, and hydroxyl radical) are thought to contribute the rapid bactericidal activity of diverse antimicrobial agents. The possibility has been raised that consumption antioxidants in food may interfere with lethal action antimicrobials. Whether nutritional supplements containing antioxidant also likely lethality is unknown. To examine this possibility, resveratrol, a popular dietary supplement, was added cultures Escherichia coli Staphylococcus...
Background Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that thought to participate in the response stress. Previous work with Escherichia coli has led a debate which some investigators conclude protect from stress, while others argue they amplify lethal stress and lead programmed cell death. To avoid ambiguity arising presence of multiple TA E. coli, effect sole module Bacillus subtilis was examined for several types Methodology/Principal Findings...
Increasingly studies revealed that dysbiosis of gut microbiota plays a pivotal role in the pathogenesis ulcerative colitis (UC). Fecal transplantation (FMT) has drawn more and attention become an important therapeutic approach. This study aims to examine facts about effective components look into potential mechanisms FMT. Colitis was induced by 3% (w/v) dextran sulfate sodium (DSS) drinking water for 7 days. mice were administered oral gavage with fecal suspension, supernatant, bacteria or...
Sucralose is one of the most widely used artificial sweeteners, free nutrients and calories. Its approval uses correlate with many worldwide epidemiological changes in inflammatory bowel disease (IBD). Multiple animal studies by us others showed that sucralose exacerbated ileitis SAMP1/YitFc mice 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats. In this study, we further investigated effect on dextran sulfate sodium (DSS)-induced associated mechanisms. Male C57BL/6 received...
Deoxyelephantopin (DET) is a kind of natural active ingredient extracted from the Chinese herbal medicine Elephantopus scaber L. Many studies have revealed potential antitumor effect on multiple malignancies. However, detailed mechanism its in pancreatic cancer remains unclear. Recently, confirmed that noncoding RNA (ncRNA) plays an important regulatory role This research was performed to explore relationship between ncRNA and DET-induced tumor inhibition cancer. Microarray profiling applied...
The authors previously demonstrated that unconjugated bilirubin (UCB) may inhibit the activities of various digestive proteases, including trypsin and chymotrypsin. proteases in lower gut are important pathogenesis inflammatory bowel diseases. effects UCB on inflammation levels feces rats with colitis have not yet been revealed. present study investigated effect status chymotrypsin trinitrobenzenesulfonic acid (TNBS)‑induced colitis. data indicated treatment TNBS resulted a marked reduction...
Abstract A regioselective Markovnikov hydroarylation of arylcyclobutene has been developed using Brønsted acid catalysis through a protonation/Friedel‐Crafts sequence. The metal‐free catalytic reaction is operationally simple and feasible compared to previous reports that utilized elaborate specific polyfluorinated reagents, affording variety gem ‐diaryl‐ substituted in good yields. possible mechanism the explored step‐by‐step control experiments. This protocol involving indole...
Accurate diagnosis and assessment of breast cancer treatment responses are critical challenges in clinical practice, influencing patient strategies ultimately long-term prognosis. Currently, diagnosing evaluating the efficacy neoadjuvant immunotherapy (NAIT) primarily rely on pathological identification tumor cell morphology, count, arrangement. However, when tumors small, beds difficult to detect; relying solely may lead false negatives. In this study, we used label-free multiphoton...
Background Studies have shown that the absence of bile in gut lumen, either by duct ligation or diversion, induces mucosal injury. However, mechanism remains elusive. In this study, role pigments barrier function was investigated a rat model ligation. Methods Male Sprague Dawley (SD) rats were used study. After duct, animals administrated with free bilirubin, bilirubin ditaurate, biliverdin intragastric gavage. 1, 2, 3 days later, sacrificed and damage mucosa assessed histological staining...