A5011632939- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Biochemical Analysis and Sensing Techniques
- Animal Virus Infections Studies
- Fungal Infections and Studies
- Phytoplasmas and Hemiptera pathogens
- Ferroptosis and cancer prognosis
- Inflammatory Bowel Disease
- Metabolism and Genetic Disorders
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
- Identification and Quantification in Food
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Genetically Modified Organisms Research
- Cannabis and Cannabinoid Research
- Antifungal resistance and susceptibility
- Oral microbiology and periodontitis research
- Heme Oxygenase-1 and Carbon Monoxide
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Microbial Metabolism and Applications
- Probiotics and Fermented Foods
- Virus-based gene therapy research
Southwest University
2024
Jilin University
2024
Xuchang University
2024
Henan University of Technology
2022
Innovation Team (China)
2019-2021
Harbin Medical University
2019-2021
Jilin Agricultural University
2019
Sucralose is a calorie-free high-intensity artificial sweetener that widely used in thousands of foods and beverages all over the world. Although it had been initially regarded as safe inert food additive, its adverse effect on gut microbiota health has drawn more attention evidence accumulates. Studies by us others revealed sucralose exacerbated damage inflammation animal models for inflammatory bowel disease (IBD) including both ulcerative colitis Crohn's disease. Our study demonstrated...
Unconjugated bilirubin (UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on interaction between intestinal flora and organisms how influences immune responses remain unresolved.To investigate role UCB in barrier function inflammation mice with dextran-sulfate-sodium-induced colitis.Acute colitis was induced by 3% (w/v) dextran sulfate sodium salt drinking water 6 d followed untreated 2 d. Concurrently, were...
To simultaneously detect sweetpotato and maize components in starch products, this study develops a rapid analysis method based on ladder-shape melting temperature isothermal amplification (LMTIA) coupled with proofreading enzyme-mediated probe cleavage (Proofman). Internal transcription spacer (ITS) gene sequences were targeted to design species-specific primers linked Proofman probes. The detection of duplex Proofman-LMTIA could be completed 20 min under the optimal 61 ℃. specificities ITS...
Background Disulfidptosis and ferroptosis are forms of programmed cell death that may be associated with the pathogenesis periodontitis. Our study developed periodontitis-associated biomarkers combining disulfidptosis ferroptosis, which provides a new perspective on Methods Firstly, we obtained periodontitis dataset from public databases found disulfidptosis- ferroptosis-related differentially expressed transcripts based transcript sets. After that, tissue for were using three machine...
Sucralose is one of the most widely used artificial sweeteners, free nutrients and calories. Its approval uses correlate with many worldwide epidemiological changes in inflammatory bowel disease (IBD). Multiple animal studies by us others showed that sucralose exacerbated ileitis SAMP1/YitFc mice 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats. In this study, we further investigated effect on dextran sulfate sodium (DSS)-induced associated mechanisms. Male C57BL/6 received...
Porcine epidemic diarrhea caused by porcine virus (PEDV) is a highly contagious disease in newborn piglets. The spike (S) protein the surface glycoprotein of PEDV, which can induce specific neutralization antibodies and candidate antigen for vaccination attempts. In our study, S1 region PEDV strain CH/JLDH/2016 gene was inserted into Lactococcus lactis expression vector, pNZ8149, resulting recombinant plasmid pNZ8149-S1, immunogenicity L. pNZ8149-S1/NZ3900 evaluated mice. After immunization,...
Cryptococcus neoformans is a globally distributed human fungal pathogen that can cause cryptococcal meningitis with high morbidity and mortality. In this study, we identified an anaphase-promoting complex (APC) activator, Cdh1, examined its impact on the virulence of C. neoformans. Our subcellular localization analysis revealed Cdh1 situated in nucleus Disrupting or overexpressing CDH1 gene caused abnormal capsule formation The cdh1Δ mutant displayed slight sensitivity when grown at 37 °C,...